Ross, M., Tormey, P., Ingram, L., Simpson, R., Malone, E. & Florida-James, G. (2016). A 10 km time trial running bout acutely increases the number of angiogenic T cells in the peripheral blood compartment of healthy males: Acute exercise mobilizes angiogenic T cells. Experimental Physiology. doi:10.1113/ep085771. ISSN 0958-0670
What is the central question of the study?
Are CD31+ angiogenic T (TANG) cells preferentially mobilized in response to acute exercise?
What is the main findin...
Ross, M. D., Malone, E. M. & Florida-James, G. (2015). Vascular ageing and exercise: focus on cellular reparative processes. Oxidative Medicine and Cellular Longevity. 2016doi:10.1155/2016/3583956. ISSN 1942-0900
Ageing is associated with an increased risk of developing noncommunicable diseases (NCDs), such as diabetes and cardiovascular disease (CVD). The increased risk can be attribu...
Ingram, L. A., Simpson, R. J., Malone, E. M. & Florida-James, G. (2015). Sleep disruption and its effect on lymphocyte redeployment following an acute bout of exercise. Brain, Behavior, and Immunity. 47, 100-108. doi:10.1016/j.bbi.2014.12.018. ISSN 0889-1591
Sleep disruption and deprivation are common in contemporary society and have been linked with poor health, decreased job performance and increased life-stress. The rapid redep...
Hutchison, G. R. & Malone, E. M. (2010). Nanotoxicity. In Booß-Bavnbek, B., Klösgen, B., Larsen, J., Pociot, F. & Renström, E. (Eds.). Systems Biology of Regulated Exocytosis in Pancreatic β-Cells, 419-434. Springer. doi:10.1007/978-1-4419-6956-9_18. ISBN 978-1-4419-6955-2
Nanotechnology, including the field of nanomedicine, promises to revolutionise/improve the way in which we live our lives. This atomic, molecular and macromolecular technology...
Taylor, M. D., LeGoff, L., Harris, A., Malone, E. M., Allen, J. E. & Maizels, R. M. (2005). Removal of regulatory T cell activity reverses hyporesponsiveness and leads to filarial parasite clearance in vivo. Journal of Immunology. 174, 4924 – 4933. ISSN 0022-1767
Human filarial parasites cause chronic infection associated with long-term down-regulation of the host’s immune response. We show here that CD4+ T cell regulation is the main ...
Ross, M. D., Malone, E. M., Simpson, R. J. & Florida-James, G. (2015). The influence of age and cardiorespiratory fitness on circulating angiogenic T cells and CXCR4 expression
Aging is associated with endothelial dysfunction, reduced angiogenic capabilities, and an increase in arterial stiffness. Additionally, regular exercise is known to offset the...
This project aims to develop an in vitro model that can be used to reduce and replace animal use in the safety assessment of nanoparticles.
"There is a paucity of knowledge relating to the effects of ENM on the male reproductive system. Thus, there is a clear requirement...
This PhD project is to investigate the physiological demands of elite enduro mountain bike racing. Previou...
Purpose: To investigate the physiological, immunological and psychological response to an intense ...