Principal Research Fellow
Nguyen, H. V., Zhao, Z., Sallustrau, A., Horswell, S. L., Male, L., Mulas, A. & Tucker, J. H. R. (2011). A ferrocene nucleic acid oligomer as an organometallic structural mimic of DNA. Chemical Communications. 48, 12165. doi:10.1039/C2CC36428J. ISSN 1359-7345
The design, synthesis and electrochemical behaviour of an oligomer consisting of linked thymine-functionalised ferrocene units are reported, which, as a so-called form of ferr...
Manchester, J., Bassani, D. M., Duprey, J. H. A., Giordano, L., Vyle, J. S., Zhao, Z. & Tucker, J. H. R. (2011). Photocontrolled binding and binding-controlled photochromism within anthracene-modified DNA. Journal of the American Chemical Society. 134, 10791-10794. doi:10.1021/ja304205m. ISSN 0002-7863
Modified DNA strands undergo a reversible
light-induced reaction involving the intramolecular photodimerization
of two appended anthracene tags. The
photodimers exhibit marked...
Zhao, Z., San, M., Duprey, J. H. A., Arrand, J. R., Vyle, J. S. & Tucker, J. H. R. (2011). Detection of single nucleotide polymorphisms within a sequence of a gene associated with prostate cancer using a fluorophore-tagged DNA probe. Bioorganic and Medicinal Chemistry Letters. 22, 129-132. doi:10.1016/j.bmcl.2011.11.053. ISSN 0960-894X
Single nucleotide polymorphisms within a sequence of a gene associated with prostate cancer were identified using oligodeoxynucleotide probe sequences bearing internal anthrac...
Duprey, J. H. A., Zhao, Z., Bassani, D. M., Manchester, J., Vyle, J. S. & Tucker, J. H. R. (2010). Detection of DNA base variation and cytosine methylation at a single nucleotide site using a highly sensitive fluorescent probe. Chemical Communications. 47, 6629. doi:10.1039/c1cc11205h. ISSN 1359-7345
A fluorescent DNA probe containing an anthracene group attached via an anucleosidic linker can identify all four DNA bases at a single site as well as the epigenetic modificat...