Khan, J. N., Wilmot, E. G., Leggate, M., Singh, A., Yates, T., Nimmo, M., …McCann, G. P. (2014). Subclinical diastolic dysfunction in young adults with Type 2 diabetes mellitus: a multiparametric contrast-enhanced cardiovascular magnetic resonance pilot study assessing potential mechanisms. European heart journal cardiovascular Imaging. 15(11), 1263-1269. doi:10.1093/ehjci/jeu121. ISSN 2047-2404
Aims To assess the cardiac, vascular, anthropometric, and biochemical determinants of subclinical diastolic dysfunction in younger adults with Type 2 diabetes mellitus (T2DM) ...
Wilmot, E. G., Leggate, M., Khan, J. N., Yates, T., Gorely, T., Bodicoat, D. H., …Davies, M. J. (2014). Type 2 diabetes mellitus and obesity in young adults: the extreme phenotype with early cardiovascular dysfunction. Diabetic medicine : a journal of the British Diabetic Association. 31(7), 794-798. doi:10.1111/dme.12431. ISSN 1464-5491
A pilot study to phenotype young adults (Methods
Twenty people with Type 2 diabetes (aged 18–40 years), 10 lean and 10 obese control subjects underwent detailed assessme...
Nimmo, M. A., Leggate, M., Viana, J. L. & King, J. A. (2013). The effect of physical activity on mediators of inflammation. Diabetes, obesity & metabolism. 15(s3), 51-60. doi:10.1111/dom.12156. ISSN 1463-1326
Being physically active and undertaking exercise on a regular basis are critical lifestyle behaviours which protect against the development of numerous chronic metabolic condi...
Patterson, S. D., Leggate, M., Nimmo, M. A. & Ferguson, R. A. (2012). Circulating hormone and cytokine response to low-load resistance training with blood flow restriction in older men. European Journal of Applied Physiology. 113, 713-719. doi:10.1007/s00421-012-2479-5. ISSN 1439-6319
It has been suggested that circulating hormones and cytokines are important in the adaptive response to low-load resistance training (LLRT) with blood flow restriction (BFR); ...
Leggate, M., Carter, W. G., Evans, M. J. C., Vennard, R. A., Sribala-Sundaram, S. & Nimmo, M. A. (2011). Determination of inflammatory and prominent proteomic changes in plasma and adipose tissue after high-intensity intermittent training in overweight and obese males. Journal of Applied Physiology. 112, 1353-1360. doi:10.1152/japplphysiol.01080.2011. ISSN 8750-7587
This study aimed to determine whether 2 wk of high-intensity intermittent training (HIIT) altered inflammatory status in plasma and adipose tissue in overweight and obese male...
Leggate, M., Nowell, M. A., Jones, S. A. & Nimmo, M. A. (2009). The response of interleukin-6 and soluble interleukin-6 receptor isoforms following intermittent high intensity and continuous moderate intensity cycling. Cell Stress and Chaperones. 15, 827-833. doi:10.1007/s12192-010-0192-z. ISSN 1355-8145
As interleukin-6 (IL-6), its soluble receptor (sIL-6R), and the IL-6/sIL-6R complex is transiently elevated in response to prolonged moderate-intensity exercise, this study in...
Gray, S. R., Clifford, M., Lancaster, R., Leggate, M., Davies, M. & Nimmo, M. A. (2009). The response of circulating levels of the interleukin-6/interleukin-6 receptor complex to exercise in young men. Cytokine. 47(2), 98-102. doi:10.1016/j.cyto.2009.05.011. ISSN 1043-4666
The formation of an interleukin-6/IL-6 receptor (IL-6/IL-6R) complex increases the biological activity and half-life of IL-6, with its response to exercise currently unknown. ...
Barwell, N. D., Malkova, D., Leggate, M. & Gill, J. M. R. (2008). Individual responsiveness to exercise-induced fat loss is associated with change in resting substrate utilization. Metabolism. 58, 1320-1328. doi:10.1016/j.metabol.2009.04.016. ISSN 0026-0495
Fat loss in response to exercise training varies between individuals, even when differences in compliance to the exercise program are accounted for. The purpose of this study ...
Medical Research Scotland
Medical Research Scotland (MRS) -Vacation Scholarship 2015
My main area of research interest is the role of exercise and ageing on vitamin D metabolism. Scotland is identified as a vitamin D deficient nat...
A mixed method approach to understanding the nature of psychological resielince in junior athletes, reviewing and proposi...