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Szemes, M., Davies, R. L., Garden, C. L. P. & Usowicz, M. M. (2012). Weaker control of the electrical properties of cerebellar granule cells by tonically active GABAA receptors in the Ts65Dn mouse model of Down's syndrome. Molecular Brain. 6, 33. ISSN 1756-6606
Down's syndrome (DS) is caused by triplication of all or part of human chromosome 21 and is characterized by a decrease in the overall size of the brain. One of th...
Usowicz, M. M. & Garden, C. L. P. (2012). Increased excitability and altered action potential waveform in cerebellar granule neurons of the Ts65Dn mouse model of Down syndrome. Brain Research. 1465, 10-17. doi:10.1016/j.brainres.2012.05.027. ISSN 0006-8993
Down syndrome (DS) is characterized by intellectual disability and impaired motor control. Lack of coordinated movement, poor balance, and unclear speech imply dysfunction of ...
Palmer, C., Lim, W., Hastie, P. G. R., Toward, M., Korolchuk, V. I., Burbidge, S. A., …Henley, J. M. (2005). Hippocalcin functions as a calcium sensor in hippocampal LTD. Neuron. 47, 487 - 494. doi:10.1016/j.neuron.2005.06.014. ISSN 0896-6273
It is not fully understood how NMDAR-dependent LTD causes Ca2+-dependent endocytosis of AMPARs. Here we show that the neuronal Ca2+ sensor hippocalcin binds the β2-adaptin sub...
RS Macdonald Charitable Trust
Ovine prenatal steriod exposure: a new model for neuropsychiatric disorders
Carnegie Trust for the Universities of Scotland
Towards a therapy for Spinocerebellar Ataxia 6
03 April 2017
03 April 2017
One day event sponsored by the Society for Experimental Biology, held at Edinburgh Napier Sighthill campus.
Join us for a day of presentations and discussion of student-...
Palmer, C., Cotton, L. & Henley, J. M. (2005). The molecular pharmacology and cell biology of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors. Pharmacological Reviews. 57, 253 - 277. doi:10.1124/pr.57.2.7. ISSN 0031-6997
-Amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors (AMPARs) are of fundamental importance in the brain. They are responsible for the majority of fast excitatory synapti...
Steroids play a major role in the development of the CNS with those brain areas invo...
The aim of the project is to investigate the impact of spinal mobilisation therapy in MS pa...