Katzer, F., Wheelhouse, N., Wright, F. & Longbottom, D. (2010). Novel chlamydia-like organisms as cause of bovine abortions, UK. Emerging Infectious Diseases. 16(8), 1323-1324. doi:10.3201/eid1608.091878. ISSN 1080-6040
Horne, A. W., Howie, S. E. M., Entrican, G., Horner, P., Saunders, P. T. K., Gibson, D., …Giakoumelou, S. (in press). Chlamydia trachomatis infection of human endometrial stromal cells induces defective decidualisation and chemokine release. Scientific Reports
Miscarriage affects ~20% of pregnancies and 30 maternal infections account for ~15% of early miscarriages. Chlamydia trachomatis (Ct) has been associated with miscarriage but ...
Wheelhouse, N., Flockhart, A., Aitchison, K., Livingstone, M., Finlayson, J., Flachon, V., …Longbottom, D. (2016). Experimental challenge of pregnant cattle with the putative abortifacient Waddlia chondrophila. Scientific Reports. 6, 37150. doi:10.1038/srep37150. ISSN 2045-2322
Waddlia chondrophila is a Gram-negative intracellular bacterial organism that is related to classical chlamydial species and has been implicated as a cause of abortion in catt...
Özkan, Ş., Vitali, A., Lacetera, N., Amon, B., Bannink, A., Bartley, D. J., …Kipling, R. P. (2016). Challenges and priorities for modelling livestock health and pathogens in the context of climate change. Environmental Research. 151, 130-144. doi:10.1016/j.envres.2016.07.033. ISSN 0013-9351
Climate change has the potential to impair livestock health, with consequences for animal welfare, productivity, greenhouse gas emissions, and human livelihoods and health. Mo...
Barlow, P. G., Coyle, C., Wheelhouse, N., Jacques, M., Longbottom, D., Svoboda, P., …Colin Duncan, W. (2016). Ovine trophoblasts express cathelicidin host defence peptide in response to infection. Journal of Reproductive Immunology. 117, 10-16. doi:10.1016/j.jri.2016.06.006. ISSN 0165-0378
Cationic host defence peptides (CHDP; also known as antimicrobial peptides) are key components of the immune response in the female reproductive tract. The role of the placent...
Storrie, S., Longbottom, D., Barlow, P. G. & Wheelhouse, N. (2016). MAPK activation is essential for Waddlia chondrophila induced CXCL8 expression in human epithelial cells. PLoS ONE. 11, e0152193. doi:10.1371/journal.pone.0152193. ISSN 1932-6203
Waddlia chondrophila (W. chondrophila) is an emerging agent of respiratory and reproductive
disease in humans and cattle. The organism is a member of the order Chla...
Giakoumelou, S., Wheelhouse, N., Cuschieri, K., Entrican, G., Howie, S. E. & Horne, A. W. (2016). The role of infection in miscarriage. Human Reproduction Update. 22(1), 116-33. doi:10.1093/humupd/dmv041. ISSN 1355-4786
BACKGROUND: Miscarriage is the spontaneous loss of a pregnancy before 12 weeks (early miscarriage) or from 12 to 24 weeks (late miscarriage) of gestation. Miscarriage occurs i...
Wheelhouse, N., Mearns, R., Willoughby, K., Wright, E., Turnbull, D. & Longbottom, D. (2015). Evidence of members of the Chlamydiales in bovine abortions in England and Wales. Veterinary Record. 176, 465. doi:10.1136/vr.103075. ISSN 0042-4900
Wheelhouse, N. & Longbottom, D. (2015). Chlamydia-related Organisms: Infection in Ruminants and Potential for Zoonotic transmission. Current Clinical Microbiology Reports. 2(1), 1-9. doi:10.1007/s40588-014-0011-x. ISSN 2196-5471
Cope, I., Wheelhouse, N., Pocknell, A., Dagleish, M. & Summers, B. (2014). An unusual presentation ofChlamydia pneumoniaeinfection in a Royal Python (Python regius). Veterinary record case reports. 2(1), e000086. doi:10.1136/vetreccr-2014-000086. ISSN 2052-6121
Wheelhouse, N. & Dalgleish, M. (2014). Diagnosing the causes of ruminant abortion: where are we now?. Veterinary Journal. 201(3), 243-4. doi:10.1016/j.tvjl.2014.05.042. ISSN 1090-0233
Tan, B. H. L., Skipworth, R. J. E., Wheelhouse, N. M., Fearon, K. C. H. & Ross, J. A. (2014). Absence of correlation between serum CRP levels and mitochondrial D-loop DNA mutations in gastro-oesophageal adenocarcinoma. Journal of Cancer Research and Therapeutics. 10(1), 176-9. doi:10.4103/0973-1482.131458. ISSN 0973-1482
INTRODUCTION: Both inflammation and mitochondrial DNA (mtDNA) mutation are thought to play a role in the many human cancers. The aim of this study was to evaluate the relation...
Sa, R. C. C., Cunningham, A. A., Dagleish, M. P., Wheelhouse, N., Pocknell, A., Borel, N., …Lawson, B. (2014). Psittacine beak and feather disease in a free-living ring-necked parakeet (Psittacula krameri) in Great Britain. European journal of wildlife research. 60(2), 395-398. doi:10.1007/s10344-013-0792-x. ISSN 1439-0574
The ring-necked parakeet (RNP), Psittacula krameri, is an invasive species in Great Britain (GB) which is undergoing rapid population expansion in the wild. Although it has be...
Sait, M., Livingstone, M., Clark, E. M., Wheelhouse, N., Spalding, L., Markey, B., …Longbottom, D. (2014). Genome sequencing and comparative analysis of three Chlamydia pecorum strains associated with different pathogenic outcomes. BMC Genomics. 15, 23. doi:10.1186/1471-2164-15-23. ISSN 1471-2164
BACKGROUND: Chlamydia pecorum is the causative agent of a number of acute diseases, but most often causes persistent, subclinical infection in ruminants, swine and birds. In t...
Wheelhouse, N., Coyle, C., Barlow, P. G., Mitchell, S., Greub, G., Baszler, T., …Longbottom, D. (2013). Waddlia chondrophila Infects and Multiplies in Ovine Trophoblast Cells Stimulating an Inflammatory Immune Response. PLoS ONE. 9, e102386. doi:10.1371/journal.pone.0102386. ISSN 1932-6203
Waddlia chondrophila (W. chondrophila) is an emerging abortifacient organism which has been identified in the placentae of humans and cattle. The organism is a mem...