Research Output
Bacteriostatic activity of human lactoferrin against Staphylococcus aureusis a function of its iron-binding properties and is not influenced by antibiotic resistance.
  The in vitro antistaphylococcal activity of lactoferrin and the antibiotic resistance of clinical Staphylococcus aureus isolates obtained from three different sites of infection were examined. Antibiotic, but not lactoferrin resistance correlated with selective antibiotic pressure, and nosocomial and most community isolates were antibiotic resistant, whereas only a third of each group was resistant to lactoferrin. The antimicrobial activity of lactoferrin, both in defined medium and in normal human plasma serum, was dependent upon its ferrochelating properties. Therapeutic approaches based on the use of ferrochelating agents such as lactoferrin combined with antimicrobial drugs may help to counteract the reduced efficacy of current antibiotics.

  • Type:

    Article

  • Date:

    30 November 2000

  • Publication Status:

    Published

  • Publisher

    Wiley/ Federation of European Microbiological Societies

  • DOI:

    10.1111/j.1574-695X.2001.tb00511.x

  • ISSN:

    0928-8244

  • Library of Congress:

    QR Microbiology

  • Dewey Decimal Classification:

    579 Microorganisms, fungi & algae

Citation

Aguila, A., Herrera, A. G., Morrison, D., Cosgrove, B., Perojo, A., Montesinos, I., …Brock, J. H. (2000). Bacteriostatic activity of human lactoferrin against Staphylococcus aureusis a function of its iron-binding properties and is not influenced by antibiotic resistance. FEMS Immunology and Medical Microbiology. 31, 145-152. doi:10.1111/j.1574-695X.2001.tb00511.x. ISSN 0928-8244

Authors

Keywords

Antibiotic; Antimicrobial activity; Iron; Lactoferrin; MRSA; Staphylococcus aureus;

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