Research Output

Hippocalcin functions as a calcium sensor in hippocampal LTD.

  It is not fully understood how NMDAR-dependent LTD causes Ca2+-dependent endocytosis of AMPARs. Here we show that the neuronal Ca2+ sensor hippocalcin binds the β2-adaptin subunit of the AP2 adaptor complex and that along with GluR2 these coimmunoprecipitate in a Ca2+-sensitive manner. Infusion of a truncated mutant of hippocalcin (HIP2-72) that lacks the Ca2+ binding domains prevents synaptically evoked LTD but has no effect on LTP. These data indicate that the AP2-hippocalcin complex acts as a Ca2+ sensor that couples NMDAR-dependent activation to regulated endocytosis of AMPARs during LTD.

  • Type:

    Article

  • Date:

    18 August 2005

  • Publication Status:

    Published

  • Publisher

    Elsevier

  • DOI:

    10.1016/j.neuron.2005.06.014

  • ISSN:

    0896-6273

  • Library of Congress:

    RM Therapeutics. Pharmacology

Citation

Palmer, C., Lim, W., Hastie, P. G. R., Toward, M., Korolchuk, V. I., Burbidge, S. A., …Henley, J. M. (2005). Hippocalcin functions as a calcium sensor in hippocampal LTD. Neuron. 47, 487 - 494. doi:10.1016/j.neuron.2005.06.014. ISSN 0896-6273

Authors

Keywords

AMPARs; Hippocalcin; NMDAR-dependent LTDs

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