Research Output

Impact of marathon running on cardiac structure and function in recreational runners.

  The present study examined the relationship between LV (left ventricular) function, markers of cardiac-specific damage and markers of oxidative stress in recreational runners following a marathon. Runners (n=52; 43 male and nine female; age, 35±10 years; height, 1.74±0.08 m; body mass, 75.9±8.9 kg) were assessed pre- and immediately post-marathon. LV function was assessed using standard M-mode two-dimensional Doppler echocardiography and TDI (tissue-Doppler imaging) echocardiography. Serum was analysed for cTnT (cardiac troponin-T), TEAC (Trolox equivalent antioxidant capacity; a measure of total antioxidant capacity), MDA (malondealdehyde) and 4-HNE (4-hydroxynonenal). A strong relationship was observed between standard and TDI echocardiography for all functional measures. Diastolic function was altered post-marathon characterized by a reduction in E (peak early diastolic filling: 0.79±0.11 compared with 0.64±0.16 cm/s; P

  • Type:

    Article

  • Date:

    20 September 2004

  • Publication Status:

    Published

  • Publisher

    Portland Press

  • DOI:

    10.1042/CS20040186

  • ISSN:

    0143-5221

  • Library of Congress:

    QP Physiology

Citation

Whyte, G. P., George, K., Shave, R., Dawsons, E., Stephenson, C., Edwards, B., …Simpson, R. J. (2004). Impact of marathon running on cardiac structure and function in recreational runners. Clinical Science. 108, 73-80. doi:10.1042/CS20040186. ISSN 0143-5221

Keywords

Cardiac troponin T; Echocardiography; Marathon; Tissue Doppler imaging; Reactive oxygen species; Left ventricular functioning; Oxidative stress

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