Research Output

NO-loaded Zn2+-exchanged zeolite materials: A potential bifunctional anti-bacterial strategy.

  Nitric oxide (NO) is important for the regulation of a number of diverse biological processes, including vascular tone, neurotransmission, inflammatory cell responsiveness, defence against invading pathogens and wound healing. Transition metal exchangedzeolites are nanoporous materials with high-capacity storage properties for gases such as NO. The NO stores are liberated upon contact with aqueous environments, thereby making them ideal candidates for use in biological and clinical settings. Here, we demonstrate the NO release capacity and powerful bactericidal properties of a novel NO-storing Zn2+-exchangedzeolitematerial at a 50 wt.% composition in a polytetrafluoroethylene polymer. Further to our published data showing the anti-thrombotic effects of a similar NO-loadedzeolite, this study demonstrates the anti-bacterial properties of NO-releasing zeolites against clinically relevant strains of bacteria, namely Gram-negative Pseudomonas aeruginosa and Gram-positive methicillin-sensitive and methicillin-resistant Staphylococcus aureus and Clostridium difficile. Thus our study highlights the potential of NO-loadedzeolites as biocompatible medical device coatings with anti-infective properties

  • Type:

    Article

  • Date:

    31 March 2010

  • Publication Status:

    Published

  • Publisher

    Elsevier

  • DOI:

    10.1016/j.actbio.2009.10.038

  • Library of Congress:

    RB Pathology

  • Dewey Decimal Classification:

    616 Diseases

Citation

Fox, S., Wilkinson, T. S., Wheatley, P. S., Xiao, B., Morris, R. E., Sutherland, A., …Rossi, A. G. (2010). NO-loaded Zn2+-exchanged zeolite materials: A potential bifunctional anti-bacterial strategy. Acta biomaterialia. 6, 1515-1521. doi:10.1016/j.actbio.2009.10.038. ISSN 1742-7061

Authors

Keywords

Nitric oxide; Zeolite; Anti-bacterial; Biocompatibility; Infection

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