Research Output

Steroid signalling in the ovarian surface epithelium

  Human ovarian surface epithelium (HOSE) undergoes serial injury-repair with each ovulation, which is probably why most ovarian epithelial cancers arise there. Considering the proposed inflammatory aetiology of ovarian cancer, anti-inflammatory steroid signalling might be vital for {HOSE} regulation. {HOSE} cells express hydroxysteroid dehydrogenase (HSD) enzymes that undertake prereceptor metabolism of bioinert steroidogenic precursors formed elsewhere in the body. Ovulation-associated cytokines activate anti-inflammatory cortisol from precursor cortisone in {HOSE} cells owing to up-regulation of the gene encoding 11βHSD type 1 (HSD11B1) in vitro. Cortisol further enhances its own formation and action through augmentation of cytokine-induced {HSD11B1} and glucocorticoid receptor gene expression. Understanding this feed-forward signalling process has implications for the improved diagnosis and treatment of inflammation-associated reproductive disease states such as ovarian cancer.

  • Type:

    Article

  • Date:

    27 July 2005

  • Publication Status:

    Published

  • DOI:

    10.1016/j.tem.2005.07.002

  • ISSN:

    1043-2760

  • Library of Congress:

    QR Microbiology

  • Dewey Decimal Classification:

    579 Microorganisms, fungi & algae

Citation

Rae, M. T. & Hillier, S. G. (2005). Steroid signalling in the ovarian surface epithelium. Trends in Endocrinology and Metabolism. 16(7), 327 - 333. doi:10.1016/j.tem.2005.07.002. ISSN 1043-2760

Authors

Keywords

Human ovarian surface epithelium (HOSE), ovarian epithelial cancers,

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