Research Output
The response of circulating levels of the interleukin-6/interleukin-6 receptor complex to exercise in young men
  The formation of an interleukin-6/IL-6 receptor (IL-6/IL-6R) complex increases the biological activity and half-life of IL-6, with its response to exercise currently unknown. The aim of the present study was to determine the response of circulating levels of the IL-6/IL-6R complex to exercise. Nine healthy male participants performed 1 h of cycling exercise at a workload required to elicit 90% lactate threshold. Venous blood samples were taken at rest, immediately post-exercise and after 1.5 h rest. Hemoglobin concentration and hematocrit were measured to estimate changes in plasma volume during exercise. The concentrations of IL-6, sIL-6R and the IL-6/IL-6R complex were measured via ELISA and corrected for changes in plasma volume. A single bout of acute exercise resulted in a 5-fold increase (P < 0.05) in IL-6 and a 1.2-fold increase (P < 0.05) in sIL-6R immediately after exercise. These returned to baseline at 1.5 h after the cessation of exercise. There was a 2.1-fold increase (P < 0.05) in the levels of the IL-6/IL-6R complex post-exercise with levels remaining 1.8 times elevated (P < 0.05) after 1.5 h rest. The present study has demonstrated, for the first time, that circulating levels of the IL-6/IL-6R complex are increased in response to acute exercise in young males.

  • Type:

    Article

  • Date:

    13 June 2009

  • Publication Status:

    Published

  • Publisher

    Elsevier BV

  • DOI:

    10.1016/j.cyto.2009.05.011

  • Cross Ref:

    S1043466609001422

  • ISSN:

    1043-4666

  • Library of Congress:

    RC1200 Sports Medicine

  • Dewey Decimal Classification:

    613 Personal health & safety

Citation

Gray, S. R., Clifford, M., Lancaster, R., Leggate, M., Davies, M., & Nimmo, M. A. (2009). The response of circulating levels of the interleukin-6/interleukin-6 receptor complex to exercise in young men. Cytokine, 47(2), 98-102. https://doi.org/10.1016/j.cyto.2009.05.011

Authors

Keywords

Trans-signalling, cytokines, cycling, exercise, Interleukin-6,

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