Research Output

The STR/ort mouse model of spontaneous osteoarthritis – an update

  Osteoarthritis is a degenerative joint disease and a world-wide healthcare burden. Characterized by cartilage degradation, subchondral bone thickening and osteophyte formation, osteoarthritis inflicts much pain and suffering, for which there are currently no disease-modifying treatments available. Mouse
models of osteoarthritis are proving critical in advancing our understanding of the underpinning molecular mechanisms. The STR/ort mouse is a well-recognized model which develops a natural form of osteoarthritis very similar to the human disease. In this Review we discuss the use of the STR/ort mouse in understanding this multifactorial disease with an emphasis on recent advances in its genetics and its bone, endochondral and immune phenotypes

  • Type:

    Article

  • Date:

    11 December 2016

  • Publication Status:

    Published

  • Publisher

    Elsevier BV

  • DOI:

    10.1016/j.joca.2016.12.014

  • Cross Ref:

    S1063458416304782

  • ISSN:

    1063-4584

  • Library of Congress:

    RC1200 Sports Medicine

  • Dewey Decimal Classification:

    613 Personal health & safety

  • Funders:

    Arthritis Research UK

Citation

Staines, K. A., Poulet, B., Wentworth, D. N. & Pitsillides, A. A. (2017). The STR/ort mouse model of spontaneous osteoarthritis – an update. Osteoarthritis and Cartilage. 25(6), 802-808. doi:10.1016/j.joca.2016.12.014. ISSN 1063-4584

Authors

Copyright

© 2016 The Authors. Published by Elsevier Ltd on behalf of Osteoarthritis Research Society International. This is an open access article under the CC BY license
(http://creativecommons.org/licenses/by/4.0/).

Keywords

STR/ort, Osteoarthritis, Articular cartilage, Subchondral bone,

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