Mosey, H., Núñez, J., Goring, A., Clarkin, C. E., Staines, K. A., Lee, P. D., …Javaheri, B. (in press). Sost deficiency does not alter bone’s lacunar or vascular porosity in mice. Frontiers in Materials. doi:10.3389/fmats.2017.00027
SCLEROSTIN (Sost) is expressed predominantly in osteocytes acting as a negative regulator of bone formation. In humans, mutations in the SOST gene lead to skeletal overgrowth ...