Lecturer and Research Leader in Biomedical Sciences
Sousa, F. H., Casanova, V., Findlay, F., Stevens, C., Svoboda, P., Pohl, J., …Barlow, P. G. (2017). Cathelicidins display conserved direct antiviral activity towards rhinovirus. Peptides. doi:10.1016/j.peptides.2017.07.013. ISSN 0196-9781
Human rhinoviruses (HRVs) are the most common cause of viral respiratory tract infections, and are associated with significant morbidity and mortality in immunocompromised ind...
Sousa, F. H., Casanova, V., Stevens, C. & Barlow, P. G. (2016). Antiviral host defence peptides. In Epand, R. M. (Ed.). Host Defense Peptides and Their Potential as Therapeutic Agents, 57-94. Springer. doi:10.1007/978-3-319-32949-9_3. ISBN 978-3-319-32947-5
The on going global mortality and morbidity associated with viral pathogens highlights the need for the continued development of effective, novel antiviral molecules. The anti...
Lin, Y., Stevens, C. & Hupp, T. (2007). Identification of a Dominant Negative Functional Domain on DAPK-1 That Degrades DAPK-1 Protein and Stimulates TNFR-1-mediated Apoptosis. Journal of Biological Chemistry. 282, 16792-16802. doi:10.1074/jbc.M611559200. ISSN 0021-9258
DAPK-1 is a stress-activated tumor suppressor protein that plays a role in both proapoptotic or antiapoptotic signal transduction pathways. To define mechanisms of DAPK-1 prot...
Chief Scientists Office
We have identified the human cathelicidn LL-37 as having potent direct antiviral activity against human rhinovirus (HRV), together with the capacity to alter death pathways in HRV-infected cells, as a...
Crohn's in Childhood Research Association
An investigation of commonly used IBD drugs on autophagy pathway activity and potential therapeutic benefit for treatment of paediatric IBD
Stevens, C., Lin, Y., Sanchez, M., Amin, E., Copson, E., White, H., …Hupp, T. (2007). A Germ Line Mutation in the Death Domain of DAPK-1 Inactivates ERK-induced Apoptosis. Journal of Biological Chemistry. 282, 13791-13803. doi:10.1074/jbc.M605649200. ISSN 0021-9258
p53 is activated genetically by a set of kinases that are components of the calcium calmodulin kinase superfamily, including CHK2, AMP kinase, and DAPK-1. In dissecting the me...