Lecturer in Biomedical Science
Baudel, M., Rae, M., Fraser, J. & Poole, A. (2017). The expression of the chloride co-transporters NKCC1 and KCC2 is reversed in the penumbra following. In Brain and Neuroscience: BNA 2017 Festival of Neuroscience: Abstract BookISBN n/a
Stroke is one of the major causes of death and disability worldwide. The harm caused by the interruption of blood flow to the brain
unfolds in the subsequent hours and days, s...
Wilson, M. R., Barlow, P. G., Hutchison, G. R., Guy, K., Griffiths, A., Simpson, R. J., …Stone, V. (2004). Nanoparticle and metal interactions and their impact on lung toxicology. In Proceedings of the Ninth Annual UK Review Meeting on Outdoor and Indoor Air Pollution Research, 48-50. ISBN 1 899110 88 7
No abstract available.
Donaldson, K., Hibbs, L., Heal, M., Tran, C. L., Lightbody, J., Barlow, P. G., …Stone, V. (2003). Pro-inflammatory interactions between particles, metals and lung cells. In Effects of Air Contaminants on the Respiratory Tract - Interpretations from Molecules to Meta Analysis, 245-258. ISBN 978-3-8167-6478-6
Chief Scientists Office
We have identified the human cathelicidn LL-37 as having potent direct antiviral activity against human rhinovirus (HRV), together with the capacity to alter death pathways in HRV-infected cells, as a...
Crohn's in Childhood Research Association
An investigation of commonly used IBD drugs on autophagy pathway activity and potential therapeutic benefit for treatment of paediatric IBD
Medical Research Council
Risks of developing many adult illnesses are set down as we develop in the womb, hence the environment we experience during fetal life needs to be ‘just right’. Understanding how the fetal environmen...
Dean of Applied Sciences
Senior Lecturer, Teaching Fellow, Head of Life Sciences
Associate Professor of Immunology & Infection / Director of Research, School of Applied Sciences
Martín-Aragón Baudel, M. A. S., Rae, M. T., Darlison, M. G., Poole, A. V. & Fraser, J. (2017). Preferential activation of HIF-2α adaptive signalling in neuronal-like cells in response to acute hypoxia. PLoS ONE. 12(10)doi:10.1371/journal.pone.0185664. ISSN 1932-6203
Stroke causes severe neuronal damage as disrupted cerebral blood flow starves neurons of oxygen and glucose. The hypoxia inducible factors (HIF-1α and HIF-2α) orchestrate oxyg...
Mosey, H., Núñez, J., Goring, A., Clarkin, C. E., Staines, K. A., Lee, P. D., …Javaheri, B. (in press). Sost deficiency does not alter bone’s lacunar or vascular porosity in mice. Frontiers in Materials. doi:10.3389/fmats.2017.00027
SCLEROSTIN (Sost) is expressed predominantly in osteocytes acting as a negative regulator of bone formation. In humans, mutations in the SOST gene lead to skeletal overgrowth ...
Findlay, F., Pohl, J., Svoboda, P., Shakamuri, P., McLean, K., Inglis, N. F., …Barlow, P. G. (2017). Carbon nanoparticles inhibit the antimicrobial activities of the human cathelicidin LL-37 through structural alteration. Journal of Immunology. doi:10.4049/jimmunol.1700706. ISSN 0022-1767
Host defense peptides, also known as antimicrobial peptides, are key elements of innate host defense. One host defense peptide with well-characterized antimicrobial activity i...
Sousa, F. H., Casanova, V., Findlay, F., Stevens, C., Svoboda, P., Pohl, J., …Barlow, P. G. (2017). Cathelicidins display conserved direct antiviral activity towards rhinovirus. Peptides. doi:10.1016/j.peptides.2017.07.013. ISSN 0196-9781
Human rhinoviruses (HRVs) are the most common cause of viral respiratory tract infections, and are associated with significant morbidity and mortality in immunocompromised ind...
Longbottom, D., Livingstone, M., Wheelhouse, N., Ensor, H., Rocchi, M., Maley, S., …Dalgleish, M. (2017). Pathogenic outcome following experimental infection of sheep with Chlamydia abortus variant strains LLG and POS. PLoS ONE. doi:10.1371/journal.pone.0177653. ISSN 1932-6203
This study investigated the pathogenesis of two variant strains (LLG and POS) of Chlamydia abortus, in comparison to a typical wild-type strain (S26/3) which is known to be re...
Staines, K., Javaheri, B., Hohenstein, P., Fleming, R., Ikpegbu, E., Unger, E., …Farquharson, C. (in press). Hypomorphic conditional deletion of E11/Podoplanin reveals a role in osteocyte dendrite elongation. Journal of Cellular Physiology. ISSN 0021-9541
The transmembrane glycoprotein E11/Podoplanin (Pdpn) has been implicated in the initial stages of osteocyte differentiation. However, its precise function and regulatory mecha...
Giakoumelou, S., Wheelhouse, N., Brown, J., Wade, J., Simitsidellis, I., Gibson, D., …Horne, A. W. (in press). Chlamydia trachomatis infection of human endometrial stromal cells induces defective decidualisation and chemokine release. Scientific Reports
Miscarriage affects ~20% of pregnancies and 30 maternal infections account for ~15% of early miscarriages. Chlamydia trachomatis (Ct) has been associated with miscarriage but ...
Boyde, A., Staines, K., Javaheri, B., Millan, J., Pitsillides, A. & Farquharson, C. (in press). A distinctive patchy osteomalacia characterises Phospho1 deficient mice. Journal of Anatomy. ISSN 0021-8782
The phosphatase PHOSPHO1 is involved in the initiation of biomineralisation. Bones in Phospho1 KO mice show histological osteomalacia with frequent bowing of long bones and sp...
Poulet, B., Liu, K., Plumb, D., Vo, P., Shah, M., Staines, K., …Bou-Gharios, G. (2016). Overexpression of TIMP-3 in Chondrocytes Produces Transient Reduction in Growth Plate Length but Permanently Reduces Adult Bone Quality and Quantity. PLoS ONE. 11(12), e0167971. doi:10.1371/journal.pone.0167971. ISSN 1932-6203
Bone development and length relies on the growth plate formation, which is dependent on degradative enzymes such as MMPs. Indeed, deletion of specific members of this enzyme f...
Staines, K. A., Poulet, B., Wentworth, D. N. & Pitsillides, A. A. (2017). The STR/ort mouse model of spontaneous osteoarthritis – an update. Osteoarthritis and Cartilage. 25(6), 802-808. doi:10.1016/j.joca.2016.12.014. ISSN 1063-4584
Osteoarthritis is a degenerative joint disease and a world-wide healthcare burden. Characterized by cartilage degradation, subchondral bone thickening and osteophyte formation...
Houston, D. A., Staines, K. A., MacRae, V. E. & Farquharson, C. (2016). Culture of Murine Embryonic Metatarsals: A Physiological Model of Endochondral Ossification. Journal of Visualized Experiments. doi:10.3791/54978
The fundamental process of endochondral ossification is under tight regulation in the healthy individual so as to prevent disturbed development and/or longitudinal bone growth...
Wheelhouse, N., Flockhart, A., Aitchison, K., Livingstone, M., Finlayson, J., Flachon, V., …Longbottom, D. (2016). Experimental challenge of pregnant cattle with the putative abortifacient Waddlia chondrophila. Scientific Reports. 6, 37150. doi:10.1038/srep37150. ISSN 2045-2322
Waddlia chondrophila is a Gram-negative intracellular bacterial organism that is related to classical chlamydial species and has been implicated as a cause of abortion in catt...
Society for Reproduction and Fertility
Does the gut microbiome play a role in polycystic ovary syndrome?
The University of Edinburgh
Neuromodulation can improve ovarian dysfunction in polycystic ovary syndrome (PCOS). This is achieved by four mechanisms: i) if neural signals are involved in LH action directly their modulation may ...
Undergraduate vacation scholarship application to study the legacy of prenatal programming of polycystic ovary syndrome on postnatal throid function
Polycystic ovary syndrome (PCOS) is common: more than one in 1 in 15 young women has this condition. There are many associated health problems including abnormal periods, miscarriages, infertility, ex...