Reader in Immunology & Infection / Director of Research, School of Applied Sciences
Barlow, P. G., Coyle, C., Wheelhouse, N., Jacques, M., Longbottom, D., Svoboda, P., …Colin Duncan, W. (2016). Ovine trophoblasts express cathelicidin host defence peptide in response to infection. Journal of Reproductive Immunology. 117, 10-16. doi:10.1016/j.jri.2016.06.006. ISSN 0165-0378
Cationic host defence peptides (CHDP; also known as antimicrobial peptides) are key components of the immune response in the female reproductive tract. The role of the placent...
Sousa, F. H., Casanova, V., Stevens, C. & Barlow, P. G. (2016). Antiviral host defence peptides. In Epand, R. M. (Ed.). Host Defense Peptides and Their Potential as Therapeutic Agents, 57-94. Springer. doi:10.1007/978-3-319-32949-9_3. ISBN 978-3-319-32947-5
The on going global mortality and morbidity associated with viral pathogens highlights the need for the continued development of effective, novel antiviral molecules. The anti...
Storrie, S., Longbottom, D., Barlow, P. G. & Wheelhouse, N. (2016). MAPK activation is essential for Waddlia chondrophila induced CXCL8 expression in human epithelial cells. PLoS ONE. 11, e0152193. doi:10.1371/journal.pone.0152193. ISSN 1932-6203
Waddlia chondrophila (W. chondrophila) is an emerging agent of respiratory and reproductive
disease in humans and cattle. The organism is a member of the order Chla...
Chief Scientists Office
We have identified the human cathelicidn LL-37 as having potent direct antiviral activity against human rhinovirus (HRV), together with the capacity to alter death pathways in HRV-infected cells, as a...
Barlow, P. G., Findlay, E. G., Currie, S. M. & Davidson, D. J. (2013). Antiviral potential of cathelicidins. Future Microbiology. 9, 55-73. doi:10.2217/fmb.13.135. ISSN 1746-0913
The global burden of morbidity and mortality arising from viral infections is high; however, the development of effective therapeutics has been slow. As our understanding of i...
Wheelhouse, N., Coyle, C., Barlow, P. G., Mitchell, S., Greub, G., Baszler, T., …Longbottom, D. (2013). Waddlia chondrophila Infects and Multiplies in Ovine Trophoblast Cells Stimulating an Inflammatory Immune Response. PLoS ONE. 9, e102386. doi:10.1371/journal.pone.0102386. ISSN 1932-6203
Waddlia chondrophila (W. chondrophila) is an emerging abortifacient organism which has been identified in the placentae of humans and cattle. The organism is a mem...
Barlow, P. G., Svoboda, P., Mackellar, A., Nash, A. A., York, I. A., Pohl, J., …Donis, R. O. (2010). Antiviral activity and increased host defense against influenza infection elicited by the human cathelicidin LL-37. PLoS ONE. 6. doi:10.1371/journal.pone.0025333. ISSN 1932-6203
The extensive world-wide morbidity and mortality caused by influenza A viruses highlights the need for new insights into the host immune response and novel treatment approache...
Song, J., Kim, Y., Barlow, P. G., Hossain, M. J., Park, K., Donis, R. O., …Kang, S. (2010). Improved protection against avian influenza H5N1 virus by a single microneedle skin vaccination with virus-like particles. Antiviral research. 88, 244-247. doi:10.1016/j.antiviral.2010.09.001. ISSN 0166-3542
To develop a more effective vaccination method against H5N1 virus, we investigated the immunogenicity and protective efficacy after skin vaccination using microneedles coated ...
Fox, S., Wilkinson, T. S., Wheatley, P. S., Xiao, B., Morris, R. E., Sutherland, A., …Rossi, A. G. (2010). NO-loaded Zn2+-exchanged zeolite materials: A potential bifunctional anti-bacterial strategy. Acta biomaterialia. 6, 1515-1521. doi:10.1016/j.actbio.2009.10.038. ISSN 1742-7061
Nitric oxide (NO) is important for the regulation of a number of diverse biological processes, including vascular tone, neurotransmission, inflammatory cell responsiveness, de...
Barlow, P. G., Beaumont, P. E., Cosseau, C., Mackellar, A., Wilkinson, T. S., Hancock, R. E. W., …Davidson, D. J. (2009). The human cathelicidin LL-37 preferentially promotes apoptosis of infected airway epithelium. American Journal of Respiratory Cell and Molecular Biology. 43, 692-702. doi:10.1165/rcmb.2009-0250OC. ISSN 1044-1549
Cationic host defense peptides are key, evolutionarily conserved components of the innate immune system. The human cathelicidin LL-37 is an important cationic host defense pep...
Jacobson, S., Steitz, J., Barlow, P. G., Hossain, M. J., Kim, E., Okada, K., …Gambotto, A. (2009). A candidate H1N1 pandemic influenza vaccine elicits protective Immunity in mice. PLoS ONE. 5, e10492. doi:10.1371/journal.pone.0010492. ISSN 1932-6203
In 2009 a new pandemic disease appeared and spread globally. The recent emergence of the pandemic influenza virus H1N1 first isolated in Mexico and USA raised conce...
Li, H., Barlow, P. G., Bylund, J., Mackellar, A., Bjorstad, A., Conlon, J., …Davidson, D. J. (2008). Secondary necrosis of apoptotic neutrophils induced by the human cathelicidin LL-37 is not proinflammatory to phagocytosing macrophages. Journal of Leukocyte Biology. 86, 891-902. doi:10.1189/jlb.0209050. ISSN 0741-5400
Cathelicidins are CHDP with essential roles in innate host defense but also more recently associated with the pathogenesis of certain chronic diseases. These peptides have mic...
Barlow, P. G., Brown, D. M., Donaldson, K., McCallum, J. & Stone, V. (2008). Reduced alveolar macrophage migration induced by acute
ambient particle (PM10) exposure. Cell Biology and Toxicology. 24, 243-252. doi:10.1007/s10565-007-9033-y. ISSN 0742-2091
Increased levels of particulate air pollution (PM10) have been implicated as a causal agent in pulmonary disease exacerbation and increased deaths from respiratory and cardiov...
Brown, D., Hutchison, G., Stone, V. & Barlow, P. (2006). Proinflammatory effects of particles on macrophages and epithelial cells. In Particle Toxicology, 183-196. Informa UK Limited. doi:10.1201/9781420003147.ch9. ISBN 978-0-8493-5092-4; 978-1-4200-0314-7
Barlow, P. G., Clouter-Baker, A., Donaldson, K., MacCallum, J. & Stone, V. (2005). Carbon black nanoparticles induce type II epithelial cells to release chemotaxins for alveolar macrophages. Particle and fibre toxicology. 2(11), 11-24. doi:10.1186/1743-8977-2-11. ISSN 1743-8977
Alveolar macrophages are a key cell in dealing with particles deposited in the lungs and in determining the subsequent response to that particle exposure. Nanoparti...
Barlow, P. G., Li, Y., Wilkinson, T. S., Bowdish, D. M. E., Lau, Y. E., Cosseau, C., …Davidson, D. J. (2005). The human cationic host defense peptide LL-37 mediates contrasting effects on apoptotic pathways in different primary cells of the innate immune system. Journal of Leukocyte Biology. 80, 509-520. doi:10.1189/jlb.1005560. ISSN 0741-5400
The human cathelicidin LL-37 is a cationic host defense peptide (antimicrobial peptide) expressed primarily by neutrophils and epithelial cells. This peptide, up-regulated und...