Craig Stevens

Craig Stevens

Dr Craig Stevens

Associate Professor

Biography

Dr Craig Stevens BSc PhD FHEA is Associate Professor and Principal Investigator (PI) within the School of Applied Sciences at Edinburgh Napier University (ENU). Craig completed his undergraduate degree in Biochemistry at Heriot-Watt University, Edinburgh in 1999 and his PhD from the University of Glasgow in 2004 where he studied the role of E2F transcription factors in DNA damage checkpoint control within the group of Prof Nick LaThangue. In 2004, he moved to the Edinburgh Cancer Research Centre within the Institute of Genetics & Molecular Medicine (IGMM) at the University of Edinburgh for his first Postdoctoral Research position, joining the Cell Signalling Laboratory of Prof Ted Hupp where his research focused on the control of cell growth by mechanistic target of rapamycin (mTORC1) and death-associated protein kinase (DAPK) signalling pathways. Craig stayed at the IGMM for a Senior Research Fellow position, joining the Gastroenterology Laboratory of Prof Jack Satsangi to investigate the role of autophagy in the pathogenesis of Inflammatory Bowel Disease (IBD), specifically Crohn’s disease (CD). During this time Craig helped to secure funding from the Medical Research Council (MRC), Chief Scientist Office (CSO) and the National Association of Crohn’s and Colitis (NACC).

In 2012, Craig joined the School of Applied Sciences at ENU as Lecturer and PI, was appointed Research Leader in Biomedical Sciences in October 2016 and promoted to Associate Professor in August 2018. At ENU Craig's academic role focuses on both research and teaching of undergraduate and postgraduate degrees. Research in Craig’s group is currently supported by funding from Crohn's in Childhood Research Association (CICRA) and the CSO and focusses on three main areas:

1. Understanding the role of autophagy in CD.
2. Investigating the mechanism of action of drugs commonly used to treat patients with IBD.
3. The role of host defence peptides in IBD.

The potential for translational research results from Craig's strong collaborative links with ongoing IBD research at the Royal Hospital for Sick Children, Edinburgh (Dr Paul Henderson, Consultant Paediatric Gastroenterologist) and University of Oxford (Prof Jack Satsangi, Consultant Physician). Craig also has strong collaborative links at ENU with Dr Peter Barlow investigating novel peptide based therapeutics for the treatment of IBD.

Themes

Research Areas

Esteem

Advisory panels and expert committees or witness

  • Expert reviewer for the Royal College of Surgeons (RCSI), Ireland
  • Expert reviewer for Fondation Innovations en Infectiologie (Finovi), France

 

Conference Organising Activity

  • ER Stress, Autophagy & immune system, Bruges, Belgium
  • International congress of Mucosal Immunology, Washington, USA
  • Autophagy UK meeting, London, England
  • European Crohn’s and Colitis Organisation (ECCO) congress, Barcelona, Spain
  • European Molecular Biology Organisation (EMBO) Conference, Autophagy, from molecular principals to human diseases, Dubrovnik, Croatia
  • Autophagy UK meeting, Edinburgh, Scotland
  • BSPGHAN annual meeting, Glasgow, Scotland

 

Editorial Activity

  • Editorial Board of Advances in Biology

 

Grant Reviewer

  • Medical Research Council Peer Review

 

Invited Speaker

  • United European Gastroenterology Week (UEGW), Stockholm, Sweden
  • British Society of Paediatric Gastroenterology, Hepatology and Nutrition (BSPGHAN) annual meeting, Edinburgh, Scotland
  • British Society of Gastroenterology (BSG), 1st Supraregional Meeting - Workshop: Intestinal Inflammation, Edinburgh, Scotland

 

Membership of Professional Body

  • Edinburgh Organoid Network
  • British Society for Immunology
  • Edinburgh Infectious Diseases Network

 

Public/Community Engagement

  • Crohn’s in Childhood Research Association (CICRA) academic panel that meets children and families with IBD
  • STEM ambassador

 

Research Degree External Examining

  • MRes student for the University of Edinburgh

 

Reviewing

  • Journal of Crohn's and Colitis
  • Journal of Medical Microbiology
  • Toxicology Letters
  • Journal of Cancer
  • Inflammatory Bowel Diseases

 

Date


38 results

Novel insights into DAPK autophagic signalling using peptide aptamer combinatorial protein-interaction screens

Journal Article
Stevens, C. & Hupp, T. R. (2008)
Novel insights into DAPK autophagic signalling using peptide aptamer combinatorial protein-interaction screens. Autophagy. 4(4), 531-533. doi:10.4161/auto.5940. ISSN 1554-8627
DAPK represents a relatively unique enzyme in the protein kinase superfamily whose major biological functions are linked to both autophagy and signal-mediated apoptosis. Howev...

DAPK-1 Bbnding to a linear peptide motif in MAP1B stimulates autophagy and membrane blebbing

Journal Article
Harrison, B., Kraus, M., Burch, L., Stevens, C., Craig, A., Gordon-Weeks, P., & Hupp, T. R. (2008)
DAPK-1 Bbnding to a linear peptide motif in MAP1B stimulates autophagy and membrane blebbing. Journal of Biological Chemistry, 283(15), 9999-10014. https://doi.org/10.1074/jbc.M706040200
DAPK-1 (death-activated protein kinase) has wide ranging functions in cell growth control; however, DAPK-1 interacting proteins that mediate these effects are not well defined...

Identification of a dominant negative functional domain on DAPK-1 that degrades DAPK-1 protein and stimulates TNFR-1-mediated apoptosis.

Journal Article
Lin, Y., Stevens, C., & Hupp, T. (2007)
Identification of a dominant negative functional domain on DAPK-1 that degrades DAPK-1 protein and stimulates TNFR-1-mediated apoptosis. Journal of Biological Chemistry, 282(23), 16792-16802. https://doi.org/10.1074/jbc.M611559200
DAPK-1 is a stress-activated tumor suppressor protein that plays a role in both proapoptotic or antiapoptotic signal transduction pathways. To define mechanisms of DAPK-1 prot...

A Germ Line Mutation in the Death Domain of DAPK-1 Inactivates ERK-induced Apoptosis

Journal Article
Stevens, C., Lin, Y., Sanchez, M., Amin, E., Copson, E., White, H., …Hupp, T. (2007)
A Germ Line Mutation in the Death Domain of DAPK-1 Inactivates ERK-induced Apoptosis. Journal of Biological Chemistry, 282(18), 13791-13803. https://doi.org/10.1074/jbc.m605649200
p53 is activated genetically by a set of kinases that are components of the calcium calmodulin kinase superfamily, including CHK2, AMP kinase, and DAPK-1. In dissecting the me...

The emerging role of E2F-1 in the DNA damage response and checkpoint control.

Journal Article
Stevens, C., & La Thangue, N. B. (2004)
The emerging role of E2F-1 in the DNA damage response and checkpoint control. DNA Repair, 3(8-9), 1071-1079. https://doi.org/10.1016/j.dnarep.2004.03.034
Genotoxic stress triggers a myriad of cellular responses including cell cycle arrest, stimulation of {DNA} repair and apoptosis. A central role for the E2F-1 transcription fac...

A New Role for E2F-1 in Checkpoint Control

Journal Article
Stevens, C., & Thangue, N. B. L. (2003)
A New Role for E2F-1 in Checkpoint Control. Cell Cycle, 2(5), 434-436. https://doi.org/10.4161/cc.2.5.462
In response to DNA damage, E2F-1 is induced and phosphorylated. Phosphorylated E2F-1 can reside in discrete nuclear structures and induce apoptosis, suggesting a unique role f...

Chk2 activates E2F-1 in response to DNA damage

Journal Article
Stevens, C., Smith, L., & La Thangue, N. B. (2003)
Chk2 activates E2F-1 in response to DNA damage. Nature Cell Biology, 5(5), 401-409. https://doi.org/10.1038/ncb974
The E2F-1 transcription factor is regulated during cell cycle progression and induced by cellular stress, such as DNA damage. We report that checkpoint kinase 2 (Chk2) regulat...

E2F and cell cycle control: a double-edged sword

Journal Article
Stevens, C., & La Thangue, N. B. (2003)
E2F and cell cycle control: a double-edged sword. Archives of Biochemistry and Biophysics, 412(2), 157-169. https://doi.org/10.1016/s0003-9861%2803%2900054-7
The E2F family of transcription factors plays a central role in regulating cellular proliferation by controlling the expression of both the genes required for cell cycle progr...

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