High-intensity interval training in patients with heart failure
Journal Article
Callum, K. J., Gorely, T., Crabtree, D. R., Muggeridge, D. J., & Leslie, S. J. (2020)
High-intensity interval training in patients with heart failure. British Journal of Cardiac Nursing, 15(4), 1-13. https://doi.org/10.12968/bjca.2019.0058
Cardiac rehabilitation is a key component in the secondary prevention of cardiovascular disease. However, uptake and adherence to programmes is suboptimal, especially for pati...
Exploring the mechanisms by which nitrate supplementation improves skeletal muscle contractile function: one fibre at a time
Journal Article
McIlvenna, L. C., Muggeridge, D. J., & Whitfield, J. (2020)
Exploring the mechanisms by which nitrate supplementation improves skeletal muscle contractile function: one fibre at a time. Journal of Physiology, 598(1), 25-27. https://doi.org/10.1113/jp279118
No abstract available.
Co-ingestion of Antioxidant Drinks With an Unhealthy Challenge Meal Fails to Prevent Post-prandial Endothelial Dysfunction: An Open-Label, Crossover Study in Older Overweight Volunteers
Journal Article
Muggeridge, D. J., Goszcz, K., Treweeke, A., Adamson, J., Hickson, K., Crabtree, D., & Megson, I. L. (2019)
Co-ingestion of Antioxidant Drinks With an Unhealthy Challenge Meal Fails to Prevent Post-prandial Endothelial Dysfunction: An Open-Label, Crossover Study in Older Overweight Volunteers. Frontiers in Physiology, 10, https://doi.org/10.3389/fphys.2019.01293
Eating a high calorie meal is known to induce endothelial dysfunction and it is reported that consuming drinks rich in antioxidants may be protective against this. In this stu...
Dietary nitrate supplementation alters the oral microbiome but does not improve the vascular responses to an acute nitrate dose
Journal Article
Burleigh, M., Liddle, L., Muggeridge, D. J., Monaghan, C., Sculthorpe, N., Butcher, J., …Easton, C. (2019)
Dietary nitrate supplementation alters the oral microbiome but does not improve the vascular responses to an acute nitrate dose. Nitric Oxide: Biology and Chemistry, 89, 54-63. https://doi.org/10.1016/j.niox.2019.04.010
Nitrate (NO3−) contained in food and beverages can transiently increase nitric oxide (NO) availability following a stepwise reduction to nitrite (NO2−) by commensal bacteria i...
Lower limb ischemic preconditioning combined with dietary nitrate supplementation does not influence time-trial performance in well-trained cyclists
Journal Article
McIlvenna, L. C., Muggeridge, D. J., Forrest (Nee Whyte), L. J., Monaghan, C., Liddle, L., Burleigh, M. C., …Easton, C. (2019)
Lower limb ischemic preconditioning combined with dietary nitrate supplementation does not influence time-trial performance in well-trained cyclists. Journal of Science and Medicine in Sport, 22(7), 852-857. https://doi.org/10.1016/j.jsams.2019.01.011
OBJECTIVES: Dietary nitrate (NO3-) supplementation and ischaemic preconditioning (IPC) can independently improve exercise performance. The purpose of this study was to explore...
Variability in nitrate-reducing oral bacteria and nitric oxide metabolites in biological fluids following dietary nitrate administration: An assessment of the critical difference
Journal Article
Liddle, L., Burleigh, M. C., Monaghan, C., Muggeridge, D. J., Sculthorpe, N., Pedlar, C. R., …Easton, C. (2019)
Variability in nitrate-reducing oral bacteria and nitric oxide metabolites in biological fluids following dietary nitrate administration: An assessment of the critical difference. Nitric Oxide: Biology and Chemistry, 83, 1-10. https://doi.org/10.1016/j.niox.2018.12.003
There is conflicting evidence on whether dietary nitrate supplementation can improve exercise performance. This may arise from the complex nature of nitric oxide (NO) metaboli...
To clot or not to clot? That is a free radical question
Journal Article
Crabtree, D. R., Muggeridge, D., Leslie, S. J., Megson, I. L., & Cobley, J. N. (2018)
To clot or not to clot? That is a free radical question. Journal of Physiology, 596(20), 4805-4806. https://doi.org/10.1113/jp276786
nravelling the biological roles of reactive oxygen species (ROS) is challenging (Murphy et al. 2011). There are three key challenges: (1) the global term ‘ROS’ subsumes chemic...
Salivary nitrite production is elevated in individuals with a higher abundance of oral nitrate-reducing bacteria
Journal Article
Burleigh, M. C., Liddle, L., Monaghan, C., Muggeridge, D. J., Sculthorpe, N., Butcher, J. P., …Easton, C. (2018)
Salivary nitrite production is elevated in individuals with a higher abundance of oral nitrate-reducing bacteria. Free Radical Biology and Medicine, 120, 80-88. https://doi.org/10.1016/j.freeradbiomed.2018.03.023
Nitric oxide (NO) can be generated endogenously via NO synthases or via the diet following the action of symbiotic nitrate-reducing bacteria in the oral cavity. Given the impo...
The effects of two different doses of ultraviolet-A light exposure on nitric oxide metabolites and cardiorespiratory outcomes
Journal Article
Monaghan, C., McIlvenna, L. C., Liddle, L., Burleigh, M., Weller, R. B., Fernandez, B. O., …Easton, C. (2018)
The effects of two different doses of ultraviolet-A light exposure on nitric oxide metabolites and cardiorespiratory outcomes. European Journal of Applied Physiology, 118(5), 1043-1052. https://doi.org/10.1007/s00421-018-3835-x
PURPOSE: The present study investigated different doses of ultraviolet-A (UV-A) light on plasma nitric oxide metabolites and cardiorespiratory variables.
METHODS: Ten healthy...
Untargeted Metabolomics Profiling of an 80.5 km Simulated Treadmill Ultramarathon
Journal Article
Howe, C. C., Alshehri, A., Muggeridge, D., Mullen, A., Boyd, M., Spendiff, O., …Watson, D. (2018)
Untargeted Metabolomics Profiling of an 80.5 km Simulated Treadmill Ultramarathon. Metabolites, 8(1), https://doi.org/10.3390/metabo8010014
Metabolomic profiling of nine trained ultramarathon runners completing an 80.5 km self-paced treadmill-based time trial was carried out. Plasma samples were obtained from veno...