Mick Rae
Mick Rae

Prof Mick Rae

Professor

Biography

Having begun my career at what was then Napier College of Commerce and Technology, then became Napier Polytechnic, I graduated in 1991 with an honours degree in Biological Sciences. This fostered an interest/obsession in the research field of reproduction, which I was fortunate to be able to pursue in the University of Edinburgh medical School, leading to the award of PhD in 1995. I then spent two years in the University of Kent working on projects examining novel cancer imaging techniques, which hugely boosted my laboratory skills, prior to returning to the field of reproductive sciences in 1997 at what is now the James Hutton Institute in Aberdeen. I returned to the University of Edinburgh in 2001, and remained there, working on ovarian function and cancer, until my initial appointment as a lecturer in Edinburgh Napier University. Becoming Reader in Reproductive Biology in 2012, I have continued to pursue my reproductive research interests, focusing upon the influence the prenatal environment has upon lifelong health – we are living longer, and ‘healthspan’ has to keep pace with lifespan if we are to maximise our quality of life, hence ensuring that we begin our lives with the best possible health opportunities for life is something I am very keen to contribute to.
In my spare time, I attempt to keep a classic car on the road, and enjoy fishing for wild brown trout all over Scotland.

Themes

Research Areas

Esteem

Advisory panels and expert committees or witness

  • Society for Reproduction and Fertility, Council member 2011-2015

 

Conference Organising Activity

  • Lead organiser of National Ovarian Workshop 2005
  • Invited chair, University of Oxford SRF annual conference 2015 – session: ‘oocytes’
  • Local organiser of the 2nd World Congress of Reproductive Biology, Edinburgh International Conference Centre, 2014
  • Invited chair: Royal Society of Edinburgh, Special conference in recognition of scientific contributions of Professor AS McNeilly, Ovary session 2014
  • Invited chair: University of Cambridge SRF annual conference 2014, session: plenary opening

 

Editorial Activity

  • Editorial board member

 

External Examining/Validations

  • External examination of PhD University of Southampton
  • University of Nottingham Veterinary School, external examiner for 2nd year of veterinary studies
  • PhD external examiner: University of Aberdeen, University of Nottingham

 

Fellowships and Awards

  • Honorary Fellow in the Deanery of Clinical Sciences, in the College of Medicine and Veterinary Medicine, The University of Edinburgh

 

Invited Speaker

  • Prenatal steroids programme metabolic dysfunction in sheep
  • How reproduction works (more or less)
  • Invited speaker at INRA (Paris)
  • Invited speaker at Perth Zoo, Australia
  • Invited speaker University of Edinburgh: ‘How to build an academic career’
  • Invited speaker at SRUC 2014 – ‘how biomedical and agricultural scientists can benefit from each other more’.
  • Invited speaker at Murdoch University

 

Reviewing

  • Ad hoc reviewer of scientific articles for numerous (>3) international journals

 

Date


63 results

Lysyl Oxidase Gene Expression and Enzyme Activity in the Rat Ovary: Regulation by Follicle-Stimulating Hormone, Androgen, and Transforming Growth Factor-β Superfamily Members in Vitro

Journal Article
Harlow, C. R., Rae, M., Davidson, L., Trackman, P. C., & Hillier, S. G. (2003)
Lysyl Oxidase Gene Expression and Enzyme Activity in the Rat Ovary: Regulation by Follicle-Stimulating Hormone, Androgen, and Transforming Growth Factor-β Superfamily Members in Vitro. Endocrinology, 144(1), 154-162. https://doi.org/10.1210/en.2002-220652
Lysyl oxidase (LOX) catalyzes the final enzymatic reaction required for cross-linking of collagen and elastin fibers and therefore has a crucial role in regulating the formati...

Effect of maternal undernutrition on fetal testicular steroidogenesis during the CNS androgen-responsive period in male sheep fetuses

Journal Article
Rae, M., Rhind, S., Fowler, P., Miller, D. W., Kyle, C., & Brooks, A. (2002)
Effect of maternal undernutrition on fetal testicular steroidogenesis during the CNS androgen-responsive period in male sheep fetuses. Reproduction, 124, 33-39. https://doi.org/10.1530/rep.0.1240033
The aim of this study was to determine the effects of maternal undernutrition, applied during physiologically relevant stages of development of the reproductive system, on rep...

Non-genomic steroid receptors in the bovine ovary

Journal Article
Bramley, T., Menzies, G., Rae, M., & Scobie, G. (2002)
Non-genomic steroid receptors in the bovine ovary. Domestic Animal Endocrinology, 23(1-2), 3-12. https://doi.org/10.1016/S0739-7240%2802%2900140-6
Over the last few years, rapid and physiologically important non-genomic actions of all classes of steroid hormones have been described in many cell types. A putative non-geno...

Maternal undernutrition alters triiodothyronine concentrations and pituitary response to GnRH in fetal sheep

Journal Article
Rae, M., Rhind, S., Kyle, C., Miller, D. W., & Brooks, A. (2002)
Maternal undernutrition alters triiodothyronine concentrations and pituitary response to GnRH in fetal sheep. Journal of Endocrinology, 173, 449-455. https://doi.org/10.1677/joe.0.1730449
The aims of this study were to determine which hormones may have a role in the expression of maternal undernutrition effects on reproductive function, in both the developing f...

The effects of undernutrition, in utero, on reproductive function in adult male and female sheep

Journal Article
Rae, M., Kyle, C., Miller, D., Hammond, A., Brooks, A., & Rhind, S. (2002)
The effects of undernutrition, in utero, on reproductive function in adult male and female sheep. Animal Reproduction Science, 72(1-2), 63-71. https://doi.org/10.1016/S0378-4320%2802%2900068-4
The aim of this study was to determine the effects of maternal undernutrition during pregnancy on adult reproductive function in male and female offspring. Groups of ewes were...

Effect of maternal undernutrition during pregnancy on early ovarian development and subsequent follicular development in sheep fetuses

Journal Article
Rae, M., Palassio, S., Kyle, C., Brooks, A., Lea, R., Miller, D., & Rhind, S. (2001)
Effect of maternal undernutrition during pregnancy on early ovarian development and subsequent follicular development in sheep fetuses. Reproduction, 122, 915-922. https://doi.org/10.1530/rep.0.1220915
Gonad development in female sheep fetuses is thought to occur in a number of key stages. The aim of this study was to determine the effects of maternal undernutrition, applied...

Synthesis and Characterization of 111In−DTPA−N-TIMP-2: A Radiopharmaceutical for Imaging Matrix Metalloproteinase Expression

Journal Article
Giersing, B. K., Rae, M. T., CarballidoBrea, M., Williamson, R. A., & Blower, P. J. (2001)
Synthesis and Characterization of 111In−DTPA−N-TIMP-2: A Radiopharmaceutical for Imaging Matrix Metalloproteinase Expression. Bioconjugate Chemistry, 12, 964-971. https://doi.org/10.1021/bc010028f
The matrix metalloproteinases (MMPs) are enzymes involved in the turnover of the extracellular matrix. Their overexpression in tumors is implicated in the metastatic process a...

Effects of nutrition and environmental factors on the fetal programming of the reproductive axis

Journal Article
Rhind, S., Rae, M., & Brooks, A. (2001)
Effects of nutrition and environmental factors on the fetal programming of the reproductive axis. Reproduction, 122, 205-214. https://doi.org/10.1530/rep.0.1220205
Research from a wide range of scientific disciplines has shown that the reproductive performance of animals in adult life is determined, in part, by a variety of extraneous in...

Stimulation of specific binding of [3H]-progesterone to bovine luteal cell-surface membranes: specificity of digitonin

Journal Article
Menzies, G., Howland, K., Rae, M., & Bramley, T. (1999)
Stimulation of specific binding of [3H]-progesterone to bovine luteal cell-surface membranes: specificity of digitonin. Molecular and Cellular Endocrinology, 153, 57-69. https://doi.org/10.1016/S0303-7207%2899%2900091-X
Non-genomic actions of progesterone have been described in the ovary, and luteal membranes of several species have been shown to possess specific binding sites for [3H]-proges...

Bovine ovarian non-genomic progesterone binding sites: presence in follicular and luteal cell membranes

Journal Article
Rae, M., Menzies, G., & Bramley, T. (1998)
Bovine ovarian non-genomic progesterone binding sites: presence in follicular and luteal cell membranes. Journal of Endocrinology, 159, 413-427. https://doi.org/10.1677/joe.0.1590413
We have shown recently that the bovine corpus luteum (CL) possesses specific luteal cell surface membrane binding sites for progesterone. We have now confirmed and extended th...

Previous Post Grad projects

Non-Napier PhD or MSc by Research supervisions

  • Reproductive and metabolic programming by exogenous steroids
  • Optimisation and validation of an in vitro bioassay as a tool for measuring Luteinising Hormone in several species of mammals