Nick Wheelhouse
Nick Wheelhouse

Dr Nick Wheelhouse BSc (Hons) PhD

Associate Professor

Biography

Associate Professor in microbiology and Deputy lead of the Centre for Biomedicine and Global Health within the School of Applied Sciences at Edinburgh Napier University.

I started my academic career as a Postdoctoral Research Fellow in the Department of Pathology at Edinburgh University where I worked in the areas of liver cancer and transplantation failure. It was here that I developed a keen interest in understanding the underlying causes of disease pathogenesis. I then moved to the Moredun Research Institute where I worked first as a Postdoctoral scientist and then as as Senior Postdoctoral Scientist focusing my research into the effects and impacts of bacterial infections which cause reproductive complications in both humans and livestock.

I co-lead of the Global research alliance Animal Health and Greenhouse Gas Intensity Network and I am a Trustee of the British Society for Animal Science. I hold memberships of Edinburgh Infectious Diseases, the hub for infectious disease research in Edinburgh, the Society for Reproduction and Fertility, Microbiology Society, British Society of Animal Science and I am a Fellow of the Higher Education Academy.

I have a breadth of research interests however the main areas of my research are the diagnosis, immunopathogenesis and epidemiology of reproductive infections particularly zoonoses that can be spread from animals to humans. I am particularly interested in understanding the impact of these infections on human health and quantifying their effects on livestock farming.

My work involves collaboration with multiple partner organisations in the UK and overseas, including NHS Lothian, the Institute of Biodiversity Animal Health and Comparative Medicine at the University of Glasgow in the UK where I am an Affiliated Researcher and the Royal (Dick) School of Veterinary Studies at the University of Edinburgh, where I am an honorary Fellow. Internationally I have collaborations with Kwame Nkrumah University of Science and Technology in Ghana, The University of Nairobi, and International Livestock Research Institute in Kenya.

Themes

Esteem

Advisory panels and expert committees or witness

  • Committee member Food Standards Agency Joint Expert Group on Animal Feed and Feed Additives - AFFAJEG
  • Food Standards Agency Advisory Committee on Animal Feedingstuffs - ACAF
  • Network Lead- Animal Health & Greenhouse Gas Emissions Intensity Network
  • Royal Society of Biology Animal Science Group
  • Council member- Society for Reproduction and Fertility
  • International External advisor for the Instituto Nacional de Tecnologia Agropecuaria (INTA) in Argentina (2015-)
  • Expert of Science and Technology Evaluation- National Center of Science and Technology Evaluation, Kazakhstan

 

Conference Organising Activity

  • Conference Presentation: Fertility 2022
  • Conference Presentation- Joint meeting of ESCCAR/ESCR 2022
  • Judging panel SRF Posters and 'Postdoctoral presentation' session Fertility 2022
  • Judging panel 'Postgraduate presentation' Fertility 2021
  • Conference Presentation: Fertility 2021, Online
  • Royal Society Westminster Pairing
  • Judging panel 'Postgraduate presentation' and 'Postdoctoral presentation' sessions Fertility 2020
  • Session Chair (Fertility 2020)
  • Workshop organiser: KNUST, Kumasi, Ghana
  • Judging panel 'Best Poster' and 'ECR presentation' Fertility 2019, Birmingham
  • Conference Presentation: Fertility 2018, Liverpool
  • Conference Presentation: European Society for Coxiellosis, Chlamydioses, Anaplasmoses and Rickettsioses, Marseille,
  • Conference presentation: European Society for Chlamydia Research, Cambridge
  • Conference Presentation: SRF annual meeting, Cambridge
  • Conference Presentation: Edinburgh Infectious Diseases Symposium, 2015
  • Conference Presentation: European Meeting for Animal Chlamydioses, Paris
  • Conference Presentation: European Meeting for Animal Chlamydioses, Jena
  • Conference Presentation: European Society for Chlamydia Research, Amsterdam
  • Conference Presentation: FEMAC meeting, Murcia, 2009
  • Conference Presentation: European Society for Chlamydia Research, Aarhus, Denmark
  • Conference Presentation: COST855 meeting Pulawy, Poland
  • Conference Presentation: COST855 meeting, Edinburgh
  • Conference Presentation: British Society for Immunology, Glasgow
  • Conference Presentation: British Society for Nutrition, Glasgow
  • Conference Presentation: British Society of Animal Science, Scarborough

 

Editorial Activity

  • Associate Editor Veterinary Sciences
  • Reproduction & Fertility- Associate Editor
  • Frontiers in Veterinary Science- Associate Editor
  • Editorial Board Member 'Frontiers in Microbiology'
  • Associate Editor 'Heliyon' Elsevier

 

External Examining/Validations

  • The Royal Veterinary College- External Examiner

 

Grant Funding Panel Member

  • SRF- Grant awarding committee

 

Grant Reviewer

  • Assessor Innovate UK
  • The University of Veterinary Medicine Vienna 'Top Vet Science' call
  • Research Foundation- Flanders (FWO) Grant Reviewer
  • BBSRC Grant Reviewer
  • The German Israeli Foundation for Scientific Research and Development
  • National Science Foundation (US)
  • MRC Grant Reviewer

 

Invited Speaker

  • Invited Seminar Speaker- Mazingira Centre, ILRI, Nairobi
  • Plenary Speaker 'Vision 2022', Cote d'Ivoire
  • Animal Health Network update: GRA LRG meeting 2022
  • Invited Speaker: SRF Early Career Research Workshop, Edinburgh
  • Acceptability of Extragenital Chlamydia testing in young women- NHS Research Scotland Annual Conference
  • Invited Speaker: Kumasi Centre for Collaborative Research, Kumasi, Ghana
  • Invited Speaker: Kwame Nkrumah University of Science and Technology, Kumasi, Ghaa
  • 'Q-fever' Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow
  • Invited talk: School of Life Sciences, Edinburgh Napier University
  • FACCE JPI MACSUR LiveM meeting Potsdam, June 2016 'Animal Health and Greenhouse Gas Emissions Network: Achievements and Future'
  • Sheep Veterinary Society meeting, Jersey 2010 ‘Evidence of Chlamydophila abortus vaccine strain 1B as a possible cause of ovine enzootic abortion’
  • Global Research Alliance on climate change meeting Reading, June 2015. ‘Investigations into novel pathogens associated with bovine reproductive failure’.

 

Media Activity

  • The Impact of infectious disease on livestock health-Blog
  • https://whylivestockmatter.org/articles/improving-animal-health-key-sustainable-livestock-production-and-better-human-health
  • Online Policy Brief- Improving animal health: a key to sustainable livestock production and better human health
  • Q-fever podcast- Veterinary times
  • The Sheep Farmer July/Aug 2010 ‘Chlamydial abortion’
  • The Sheep Farmer March/ April 2012 ‘Controlling chlamydial abortion’
  • ‘Chlamydial infection of sheep an infectious cause of prenatal lamb death’ http://www.knowledgescotland.org/briefings.php?id=209
  • The Crofter Issue 88 Aug 2010 ‘Controlling chlamydial abortion in sheep’

 

Membership of Professional Body

  • Fellow of the Higher Education Academy

 

Public Engagement Activity

  • Moredun Animal Health Roadshow (Peebles) 2011
  • Royal Highland Show 2011
  • NSA National Event 2010
  • National Sheep Association (NSA) Scotsheep 2010
  • NSA Scotsheep 2011
  • Royal Highland Show 2013
  • Royal Highland Show 2010

 

Public/Community Engagement

  • Livestock Health Workshop- Nandi County Kenya

 

Research Degree External Examining

  • External PhD examination University of Southampton 'Studies on the plasmid-based genetic tools for C. muridarum: progress towards a replicating vector for transposon mutagenesis'
  • University College Dublin PhD examiner 'Bovine sperm sexing impacts sperm morphokinetics, gameto-maternal interaction and subsequent early embryonic development'

 

Reviewing

  • Proceedings of the Royal Society B
  • Epidemiology and infection
  • Journal of Zoo and Wildlife Medicine
  • Frontiers in Microbiology
  • Transboundary and Emerging Diseases
  • Veterinary Pathology
  • Emerging Infectious Diseases
  • BMC Veterinary Research
  • Veterinary Immunology & Immunopathology
  • PeerJ
  • Veterinary Record
  • Veterinary Microbiology
  • Veterinary Journal
  • Pathogens & disease
  • Microbes & infection
  • Chemistry & Biology

 

Visiting Positions

  • International Livestock Research Institute (Nairobi)
  • Honorary Fellow Royal (Dick) School of Veterinary Studies
  • Glasgow University IBACHM- Affiliate Researcher
  • Guest Lecturer- University of Liverpool Veterinary School

 

Date


80 results

The tumor suppressor gene DLEC1 is frequently silenced by DNA methylation in hepatocellular carcinoma and induces G1 arrest in cell cycle

Journal Article
Qiu, G., Salto-Tellez, M., Ross, J. A., Yeo, W., Cui, Y., Wheelhouse, N., …Hooi, S. C. (2008)
The tumor suppressor gene DLEC1 is frequently silenced by DNA methylation in hepatocellular carcinoma and induces G1 arrest in cell cycle. Journal of Hepatology, 48(3), 433-441. https://doi.org/10.1016/j.jhep.2007.11.015
Background/Aims: The chromosome locus 3p21.3 is a ‘‘hot-spot” for chromosomal aberrations and loss of heterozygosity in cancers. The 35 genes mapped to the AP20 subregion of t...

Effect of high-fat enteral nutrition on hepatocyte injury in response to hemorrhagic shock in the rat.

Journal Article
Chu, M. M., Luyer, M. D. P., Wheelhouse, N. M., Bellamy, C. O., Greve, J. W. M., Buurman, W. A., …Wigmore, S. J. (2007)
Effect of high-fat enteral nutrition on hepatocyte injury in response to hemorrhagic shock in the rat. World Journal of Surgery. 31(8), 1693-1701. doi:10.1007/s00268-007-9107-2. ISSN 0364-2313
BACKGROUND: High-fat enteral nutrition reduces the inflammatory response following hemorrhagic shock in the rat. AIMS: We hypothesized that this intervention might also amelio...

Differential expression of hDAB2IPA and hDAB2IPB in normal tissues and promoter methylation of hDAB2IPA in hepatocellular carcinoma.

Journal Article
Qui, G., Xie, H., Wheelhouse, N., Harrison, D., Chen, G. G., Salto-Tellez, M., …Hooi, S. C. (2007)
Differential expression of hDAB2IPA and hDAB2IPB in normal tissues and promoter methylation of hDAB2IPA in hepatocellular carcinoma. Journal of Hepatology. 46(4), 655-663. doi:10.1016/j.jhep.2006.11.012. ISSN 0168-8278
BACKGROUND/AIMS: hDAB2IP is a candidate tumor suppressor gene. We studied the expression of its two variants, hDAB2IPA and hDAB2IPB, in normal tissues, and the expression and ...

The effects of macrophage migratory inhibitory factor on acute-phase protein production in primary human hepatocytes

Journal Article
Wheelhouse, N. M., Dowidar, N., Dejong, C. H. C., Garden, O. J., Powell, J. J., Barber, M. D., …Ross, J. A. (2006)
The effects of macrophage migratory inhibitory factor on acute-phase protein production in primary human hepatocytes. International Journal of Molecular Medicine, 18(5), 957-961. https://doi.org/10.3892/ijmm.18.5.957
Macrophage inhibitory factor (MIF) is a pituitary peptide released during the physiological stress response, a T-cell product secreted during the antigen-specific response and...

Immunity in the female sheep reproductive tract.

Journal Article
Entrican, G. & Wheelhouse, N. M. (2006)
Immunity in the female sheep reproductive tract. Veterinary Research. 37(3), 295-309. doi:10.1051/vetres:2006002. ISSN 0928-4249
Immune surveillance in the female reproductive tract is dependent on the interplay of many factors that include the expression of pattern recognition receptors on epithelial c...

Mitochondrial D-loop mutations and deletion profiles of cancerous and noncancerous liver tissue in hepatitis B virus-infected liver.

Journal Article
Wheelhouse, N. M., Lai, P. B. S., Wigmore, S. J., Ross, J. A. & Harrison, D. J. (2005)
Mitochondrial D-loop mutations and deletion profiles of cancerous and noncancerous liver tissue in hepatitis B virus-infected liver. British Journal of Cancer. 92, 1268-1272. doi:10.1038/sj.bjc.6602496. ISSN 0007-0920
The largest single underlying cause of hepatocellular carcinoma (HCC) worldwide is hepatitis B virus (HBV) infection. Hepatitis B virus increases cellular oxidative stress and...

Interferon-γ polymorphisms correlate with duration of survival in pancreatic cancer

Journal Article
Halma, M., Wheelhouse, N., Barber, M., Powell, J., Fearon, K., & Ross, J. (2004)
Interferon-γ polymorphisms correlate with duration of survival in pancreatic cancer. Human Immunology, 65(11), 1405-1408. https://doi.org/10.1016/j.humimm.2004.08.184
Despite progress in diagnosis and staging, pancreatic cancer still has a poor prognosis and it remains difficult to predict duration of survival in advanced pancreatic cancer....

TNF-α induced DNA damage in primary murine hepatocytes

Journal Article
Chan, Y., Gillies, S., Ross, J., Harrison, D., Wheelhouse, N., Chan, Y., …Prost, S. (2003)
TNF-α induced DNA damage in primary murine hepatocytes. International Journal of Molecular Medicine, 12(6), (889-894). doi:10.3892/ijmm.12.6.889. ISSN 1107-3756
Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide, usually arising from a background of chronic inflammatory disease. Tumor necrosis factor alpha (TNF...

Nutrient-hormone interaction in the ovine liver: methionine supply selectively modulates growth hormone-induced IGF-I gene expression.

Journal Article
Stubbs, A. K., Wheelhouse, N. M., Lomax, M. A., & Hazlerigg, D. G. (2002)
Nutrient-hormone interaction in the ovine liver: methionine supply selectively modulates growth hormone-induced IGF-I gene expression. Journal of Endocrinology, 174(2), (335-341). doi:10.1677/joe.0.1740335. ISSN 0022-0795
This study tested the hypothesis that specific amino acids are responsible for modulating the insulin-like growth factor-I (IGF-I) response to growth hormone (GH) in ovine hep...

Growth hormone and amino acid supply interact synergistically to control insulin-like growth factor-I production and gene expression in cultured ovine hepatocytes.

Journal Article
Wheelhouse, N. M., Stubbs, A. K., Lomax, M. A., & MacRae, J. C. (1999)
Growth hormone and amino acid supply interact synergistically to control insulin-like growth factor-I production and gene expression in cultured ovine hepatocytes. Journal of Endocrinology, 163(2), 353-361. https://doi.org/10.1677/joe.0.1630353
Many of the anabolic effects of growth hormone (GH) are indirect, occurring through GH-stimulated production of insulin-like growth factor-I (IGF-I) by the liver. As well as b...

Pre-Napier Funded Projects

  • BBSRC/ Zoetis IPA Chlamydia-like organisms as a novel cause of bovine reproductive failure (£1.2 M)
  • Chief Scientist Office: Mitochondrial DNA deletions in Barrett's oesophagus (£25k)
  • Melville Trust: Mitochondrial DNA mutations as a sentinel marker of hepatocarcinogenesis (£50k)

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