Sadie Kemp

Sadie Kemp

Sadie Kemp

Research Technician

Biography

After graduating from the Open University, with a bachelor degree in Natural Science, I joined a contract research organization providing research and testing services to the animal health, pharmaceutical and biotechnology industries. I was promoted from Laboratory Assistant to Technical Officer whilst at Moredun Scientific. After a couple of years I moved to the University of Edinburgh where I worked as a Research Technician and then a Research Assistant in two different labs. Since 2014 I have been employed at Edinburgh Napier University, as a Research Technician, carrying out research and providing support to postgraduate students in a range of subject areas.

Date


4 results

The SUMO Pathway Promotes Basic Helix-Loop-Helix Proneural Factor Activity via a Direct Effect on the Zn Finger Protein Senseless

Journal Article
Chen, A., Powell, L. M., Huang, Y. C., Wang, P. Y., Kemp, S. E., & Jarman, A. P. (2012)
The SUMO Pathway Promotes Basic Helix-Loop-Helix Proneural Factor Activity via a Direct Effect on the Zn Finger Protein Senseless. Molecular and Cellular Biology, 32(14), 2849-2860. https://doi.org/10.1128/mcb.06595-11
During development, proneural transcription factors of the basic helix-loop-helix (bHLH) family are required to commit cells to a neural fate. In Drosophila neurogenesis, a ke...

Immortality, but not oncogenic transformation, of primary human cells leads to epigenetic reprogramming of DNA methylation and gene expression

Journal Article
Gordon, K., Clouaire, T., Bao, X. X., Kemp, S. E., Xenophontos, M., de Las Heras, J. I., & Stancheva, I. (2014)
Immortality, but not oncogenic transformation, of primary human cells leads to epigenetic reprogramming of DNA methylation and gene expression. Nucleic Acids Research, 42(6), 3529-3541. https://doi.org/10.1093/nar/gkt1351
Tumourigenic transformation of normal cells into cancer typically involves several steps resulting in acquisition of unlimited growth potential, evasion of apoptosis and non-r...

The type III intermediate filament vimentin regulates organelle distribution and modulates autophagy

Journal Article
Biskou, O., Casanova, V., Hooper, K., Kemp, S., Wright, G. P., Satsangi, J., …Stevens, C. (2019)
The type III intermediate filament vimentin regulates organelle distribution and modulates autophagy. PLOS ONE, 14(1), https://doi.org/10.1371/journal.pone.0209665
The cytoskeletal protein vimentin plays a key role in positioning of organelles within the cytosol and has been linked to the regulation of numerous cellular processes includi...

The inflammatory bowel disease drug azathioprine induces autophagy via mTORC1 and the unfolded protein response sensor PERK

Journal Article
Hooper, K. M., Casanova, V., Kemp, S., Staines, K. A., Satsangi, J., Barlow, P. G., …Stevens, C. (2019)
The inflammatory bowel disease drug azathioprine induces autophagy via mTORC1 and the unfolded protein response sensor PERK. Inflammatory Bowel Diseases, 25(9), 1481-1496. https://doi.org/10.1093/ibd/izz039
Background Genetic studies have strongly linked autophagy to Crohn's disease (CD) and stimulating autophagy in CD patients may be therapeutically beneficial. The aim of this s...