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149 results

Type 1 diabetes patients increase CXCR4+ and CXCR7+ haematopoietic and endothelial progenitor cells with exercise, but the response is attenuated

Journal Article
Taylor, G. S., Shaw, A., Smith, K., Capper, T. E., Scragg, J. H., Cronin, M., …West, D. J. (2021)
Type 1 diabetes patients increase CXCR4+ and CXCR7+ haematopoietic and endothelial progenitor cells with exercise, but the response is attenuated. Scientific Reports, 11, https://doi.org/10.1038/s41598-021-93886-2
Background: Exercise mobilizes angiogenic cells, which stimulate vascular repair. However, limited research suggests exercise-induced increase of endothelial progenitor cell (...

Linkage of national health and social care data: a cross-sectional study of multimorbidity and social care use in people aged over 65 years in Scotland

Journal Article
Henderson, D. A., Atherton, I., McCowan, C., Mercer, S. W., & Bailey, N. (2021)
Linkage of national health and social care data: a cross-sectional study of multimorbidity and social care use in people aged over 65 years in Scotland. Age and ageing, 50(1), 176-182. https://doi.org/10.1093/ageing/afaa134
Background: Little is known about the relationship between multimorbidity and social care use (also known as long-term care). The aim of this study was to assess the relations...

In situ characterization of nanoscale strains in loaded whole joints via synchrotron X-ray tomography

Journal Article
Madi, K., Staines, K., Bay, B., Javaheri, B., Geng, H., Bodey, A., …Lee, P. (2020)
In situ characterization of nanoscale strains in loaded whole joints via synchrotron X-ray tomography. Nature Biomedical Engineering, 4(3), 343-354. https://doi.org/10.1038/s41551-019-0477-1
Imaging techniques for quantifying changes in the hierarchical structure of deforming joints are constrained by destructive sample treatments, sample-size restrictions and len...

Raman spectroscopy links differentiating osteoblast matrix signatures to pro-angiogenic potential

Journal Article
Sharma, A., Goring, A., Staines, K., Emery, R., Pitsillides, A. A., Oreffo, R. O., …Clarkin, C. E. (2020)
Raman spectroscopy links differentiating osteoblast matrix signatures to pro-angiogenic potential. Matrix Biology Plus, 5, https://doi.org/10.1016/j.mbplus.2019.100018
Mineralization of bone is achieved by the sequential maturation of the immature amorphous calcium phase to mature hydroxyapatite and is central to the process of bone developm...

Development of a design tool to optimise acceptance of exoskeletons by older adults

Thesis
Shore, L. (2019)
Development of a design tool to optimise acceptance of exoskeletons by older adults. (Dissertation). University of Limerick, Ireland. Retrieved from http://researchrepository.napier.ac.uk/Output/2757643
Older adults may have some prior use and knowledge of technology, but may also express or experience the digital divide, whereby the pace of emerging technology can present ch...

Dementia in the workplace: are employers supporting employees living with dementia?

Journal Article
Egdell, V., Cook, M., Stavert, J., Ritchie, L., Tolson, D., & Danson, M. (in press)
Dementia in the workplace: are employers supporting employees living with dementia?. Aging & mental health, https://doi.org/10.1080/13607863.2019.1667299
Objectives As working lives extend and there is better recognition of early-onset dementias, employers need to consider dementia as a workplace concern. With suitable support,...

The effectiveness of home versus community-based weight control programmes initiated soon after breast cancer diagnosis: a randomised controlled trial

Journal Article
Harvie, M., Pegington, M., McMullan, D., Bundred, N., Livingstone, K., Campbell, A., …Howell, A. (2019)
The effectiveness of home versus community-based weight control programmes initiated soon after breast cancer diagnosis: a randomised controlled trial. British Journal of Cancer, 121(6), 443–454. https://doi.org/10.1038/s41416-019-0522-6
Background Breast cancer diagnosis may be a teachable moment for lifestyle behaviour change and to prevent adjuvant therapy associated weight gain. We assessed the acceptabili...

Conditional deletion of E11/podoplanin in bone protects against load-induced osteoarthritis

Journal Article
Staines, K., Ikpegbu, E., Törnqvist, A., Dillon, S., Javaheri, B., Amin, A. K., …Farquharson, C. (2019)
Conditional deletion of E11/podoplanin in bone protects against load-induced osteoarthritis. BMC Musculoskeletal Disorders, 20, https://doi.org/10.1186/s12891-019-2731-9
Background: Subchondral bone (SCB) thickening is one of the earliest detectable changes in osteoarthritic joints and is considered a potential trigger for subsequent articular...

How to build a bone: PHOSPHO1, biomineralization and beyond

Journal Article
Dillon, S., Staines, K. A., Millán, J. L., & Farquharson, C. (2019)
How to build a bone: PHOSPHO1, biomineralization and beyond. Journal of Bone and Mineral Research Plus, 3(7), https://doi.org/10.1002/jbm4.10202
Since its characterization two decades ago, the phosphatase PHOSPHO1 has been the subject of an increasing focus of research. This work has elucidated PHOSPHO1’s central role ...

The effect of exporting hospitality and tourism degrees overseas on the home campus: a conceptual model.

Journal Article
Lagiewski, R. M., Barron, P., & Leask, A. (2019)
The effect of exporting hospitality and tourism degrees overseas on the home campus: a conceptual model. Journal of hospitality, leisure, sport & tourism education, 24, 211-222. https://doi.org/10.1016/j.jhlste.2019.03.005
Hospitality and tourism programmes have, over the recent decades, been involved in the delivery of their degrees in international locations through a variety of export models....
10 results

A Reinforcement Learning Based Resource Management System for Long Term Care for Elderly People

2021 - 2023
A reinforcement learning method will model the behaviour of community care organisations with sequential decision processes focusing on organising the distribution, procurement and management of daily...
Funder: Royal Society of Edinburgh | Value: £11,200

Care Home Digital Foundations Landscape Assessment in South East Scotland

2021 - 2022
To conduct a Regional landscape assessment of the current digital foundations of care homes in the area. This work would identify for all care homes in the region details of (1) digital connectivity;...
Funder: Scottish Funding Council | Value: £43,985

Uncovering novel effectors of Nrf2 dysregulation in the progression of Alzheimer's Disease

2020 - 2021
Nrf2 activators show pre-clinical promise in the treatment of several neurodegenerative diseases, including Alzheimer’s disease (AD), but exert clinical toxicity. Nrf2 regulates hundreds of anti-oxida...
Value: £4,219

Care Home Data Platform

2019 - 2021
Care home research to develope a data and innovation platform to support inclusive, person-centred research in care homes in Lothian
Funder: NHS Lothian | Value: £28,882

Implementation, at Scale, of a Model to support NICE Guidelines for the Management of Osteoarthritis (OA) in Primary Care

2019 - 2021
Musculoskeletal pain in adults over the age of 45 is the number one cause of disability world-wide and osteoarthritis (OA) is the most common cause of pain and disability (Global Burden of Disease 201...
Funder: University of Dundee | Value: £34,899

Osteoarthritis: Going back to basics

2018 - 2021
Osteoarthritis (OA) is the most important ageing-related musculoskeletal disease, affecting almost 9 million people in the UK. Despite this, there remain many unanswered questions in our understanding...
Funder: Medical Research Council | Value: £351,321

Development of a novel 3D culture system to understand bone:cartilage crosstalk in osteoarthritis

2018 - 2022
Osteoarthritis affects more than 9 million people in the UK and is the leading cause of disability. In osteoarthritis, joint tissues (cartilage and bone) undergo structural damage which ultimately pro...
Funder: Medical Research Scotland | Value: £128,430

Imaging dynamics in biophysical/biochemical processes across the hierarchical scales (BioPro Network)

2018 - 2022
The ImagingBioPro network seeks to develop new, high energy imaging methods to capture the dynamic biochemical and biophysical processes in biological samples. The human body is highly structured – f...
Funder: Biotechnology and Biological Sciences Research Council | Value: £1,500

Investigating new therapies for osteoarthritis: a collaboration between ENU and Guangzhou Medical University, China

2018 - 2022
Investigating new therapies for osteoarthritis: a collaboration between ENU and Guangzhou Medical University, China Osteoarthritis is the most important ageing-related disease, estimated to affect 13...
Funder: ENU Development Trust | Value: £30,000

Senior Visitors to Visitor Attractions

2017 - 2018
This project aims to develop a new and innovative structured visit programme focused on the needs and wants of this increasingly significant older population group. Specifically aimed at the over 75 y...
Funder: Edinburgh Innovations Ltd | Value: £9,972

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