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60 results

Chlamydia inhibits progesterone receptor mRNA expression in SHT-290 cells

Journal Article
Brown, M., Rae, M., & Wheelhouse, N. (2021)
Chlamydia inhibits progesterone receptor mRNA expression in SHT-290 cells. Reproduction and Fertility, 2(1), 9-11. https://doi.org/10.1530/RAF-20-0069
Chlamydia trachomatis is the most commonly diagnosed sexually transmitted infection in the UK, with over 200,000 positive diagnoses annually. The infection is thought to cause...

Pubertal FGF21 deficit is central in the metabolic pathophysiology of an ovine model of polycystic ovary syndrome

Journal Article
Siemienowicz, K. J., Furmanska, K., Filis, P., Talia, C., Thomas, J., Fowler, P. A., …Colin Duncan, W. (2021)
Pubertal FGF21 deficit is central in the metabolic pathophysiology of an ovine model of polycystic ovary syndrome. Molecular and Cellular Endocrinology, 525, https://doi.org/10.1016/j.mce.2021.111196
Polycystic ovary syndrome (PCOS), affecting over 10% of women, is associated with insulin resistance, obesity, dyslipidaemia, fatty liver and adipose tissue dysfunction. Its p...

Early pregnancy maternal progesterone administration alters pituitary and testis function and steroid profile in male fetuses

Journal Article
Siemienowicz, K. J., Wang, Y., Marečková, M., Nio-Kobayashi, J., Fowler, P. A., Rae, M. T., & Duncan, W. C. (2020)
Early pregnancy maternal progesterone administration alters pituitary and testis function and steroid profile in male fetuses. Scientific Reports, 10(1), https://doi.org/10.1038/s41598-020-78976-x
Maternal exposure to increased steroid hormones, including estrogens, androgens or glucocorticoids during pregnancy results in chronic conditions in offspring that manifest in...

Aberrant subcutaneous adipogenesis precedes adult metabolic dysfunction in an ovine model of polycystic ovary syndrome (PCOS)

Journal Article
Siemienowicz, K. J., Coukan, F., Franks, S., Rae, M. T., & Colin Duncan, W. (2021)
Aberrant subcutaneous adipogenesis precedes adult metabolic dysfunction in an ovine model of polycystic ovary syndrome (PCOS). Molecular and Cellular Endocrinology, 519, https://doi.org/10.1016/j.mce.2020.111042
Polycystic ovary syndrome (PCOS) affects over 10% of women. Insulin resistance, elevated free fatty acids (FFAs) and increased adiposity are key factors contributing to meta...

Insights into manipulating postprandial energy expenditure to manage weight gain in polycystic ovary syndrome (PCOS)

Journal Article
Siemienowicz, K., Rae, M. T., Howells, F., Anderson, C., Nicol, L. M., Franks, S., & Duncan, W. C. (2020)
Insights into manipulating postprandial energy expenditure to manage weight gain in polycystic ovary syndrome (PCOS). iScience, 23(6), https://doi.org/10.1016/j.isci.2020.101164
Women with polycystic ovary syndrome (PCOS) are more likely to be obese and have difficulty in losing weight. They demonstrate an obesity-independent deficit in adaptive energ...

Dyslipidaemia and altered hepatic function in males - consequences of androgen excess in fetal life

Journal Article
Siemienowicz, K., Filis, P., Shaw, S., Douglas, A., Thomas, J., Howie, F., …Rae, M. (2019)
Dyslipidaemia and altered hepatic function in males - consequences of androgen excess in fetal life. Endocrine abstracts, 63, https://doi.org/10.1530/endoabs.63.P669
Introduction: Adult male offspring of women with PCOS have increased dyslipidaemia, characterised by elevated triglycerides (TG), increased total and LDL-cholesterol (LDL-C), ...

Fetal androgen exposure is a determinant of adult male metabolic health

Journal Article
Siemienowicz, K. J., Filis, P., Shaw, S., Douglas, A., Thomas, J., Mulroy, S., …Rae, M. T. (2019)
Fetal androgen exposure is a determinant of adult male metabolic health. Scientific Reports, 9, https://doi.org/10.1038/s41598-019-56790-4
Androgen signalling is a critical driver of male development. Fetal steroid signalling can be dysregulated by a range of environmental insults and clinical conditions. We hypo...

Urinary estrogens as a non-invasive biomarker of viable pregnancy in the giant panda (Ailuropoda melanoleuca)

Journal Article
Wilson, K. S., Wauters, J., Valentine, I., McNeilly, A., Girling, S., Li, R., …Duncan, W. C. (2019)
Urinary estrogens as a non-invasive biomarker of viable pregnancy in the giant panda (Ailuropoda melanoleuca). Scientific Reports, 9(1), https://doi.org/10.1038/s41598-019-49288-6
Female giant pandas show complex reproductive traits, being seasonally monoestrus, displaying a variable length embryonic diapause and exhibiting pseudopregnancy. Currently, t...

Urinary specific gravity as an alternative for the normalisation of endocrine metabolite concentrations in giant panda (Ailuropoda melanoleuca) reproductive monitoring

Journal Article
Wauters, J., Wilson, K. S., Bouts, T., Valentine, I., Vanderschueren, K., Ververs, C., …Vanhaecke, L. (2018)
Urinary specific gravity as an alternative for the normalisation of endocrine metabolite concentrations in giant panda (Ailuropoda melanoleuca) reproductive monitoring. PLOS ONE, 13(7), https://doi.org/10.1371/journal.pone.0201420
Reproductive monitoring for captive breeding in giant pandas is based on behavioural observation and non-invasive hormone analysis. In urine, interpretation of results require...

Preferential activation of HIF-2α adaptive signalling in neuronal-like cells in response to acute hypoxia

Journal Article
Martín-Aragón Baudel, M. A. S., Rae, M. T., Darlison, M. G., Poole, A. V., & Fraser, J. A. (2017)
Preferential activation of HIF-2α adaptive signalling in neuronal-like cells in response to acute hypoxia. PLOS ONE, 12(10), https://doi.org/10.1371/journal.pone.0185664
Stroke causes severe neuronal damage as disrupted cerebral blood flow starves neurons of oxygen and glucose. The hypoxia inducible factors (HIF-1α and HIF-2α) orchestrate oxyg...

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5 results

Can exposure to excess androgen during fetal life increase risk of hepatic disease in male offspring?

2019 - 2019
Background Polycystic ovary syndrome (PCOS) is a common condition. Hyperandrogenaemia characterises PCOS, and is considered an ‘in utero environmental programmer’ of PCOS in female offspring. Male o...
Funder: Society for Reproduction and Fertility | Value: £3,000

Sex-specific disease aetiology from developmental steroid insults: mechanistic understanding and biomarker development towards disease prevention

2017 - 2021
Risks of developing many adult illnesses are set down as we develop in the womb, hence the environment we experience during fetal life needs to be ‘just right’. Understanding how the fetal environmen...
Funder: Medical Research Council | Value: £636,509

Does the gut microbiome play a role in polycystic ovary syndrome?

2017 - 2018
Does the gut microbiome play a role in polycystic ovary syndrome?
Funder: Society for Reproduction and Fertility | Value: £12,250

PCOS and Thyroid dysfunction

2015 - 2015
Undergraduate vacation scholarship application to study the legacy of prenatal programming of polycystic ovary syndrome on postnatal throid function
Funder: Society for Reproduction and Fertility | Value: £2,750

Polycystic ovary syndrome (PCOS) developmental model

2010 - 2014
Polycystic ovary syndrome (PCOS) is common: more than one in 1 in 15 young women has this condition. There are many associated health problems including abnormal periods, miscarriages, infertility, ex...
Funder: Medical Research Council | Value: £130,956
16 results

The influence of menstral cycle on training schedules in female mountain bike athletes.

2021 - date
Miss Robyn Aitkenhead | Director of Studies: Dr Lesley Ingram-Sills | Second Supervisor: Prof Geraint Florida-James

Gender differences and STEM subjects: the role of professional role confidence and gender identity

2017 - date
Kamila Krol | Director of Studies: Dr Tony Westbury | Second Supervisor: Dr Sally Brown

An investigation of the long-term effects of prenatal androgen excess in the male liver

2017 - date
Jennifer Mcgeachie | Director of Studies: Prof Mick Rae | Second Supervisor: Dr Amy Poole

Analysing the physiological and molecular mechanisms of metastasis inhibition by Kisspeptins

2016 - 2018
Miguel Hernandez Madrigal | Director of Studies: Dr Sharron Vass | Second Supervisor: Prof Mick Rae

Fatigue and the mind-body relation: A Lacanian exploration

2016 - date
This PhD project aims to explore the role of discourse in the formation and manifestation of symptoms related to the condition Chronic Fatigue...
Amanda Diserholt | Director of Studies: Dr Calum Neill | Second Supervisor: Adele Dickson

Performance in enduro mountain biking: the influence of training status, recovery and vibration

2016 - 2019
This PhD project is to investigate the physiological demands of elite enduro mountain bike racing. Previ...
Dr Lewis Kirkwood | Director of Studies: Prof Geraint Florida-James | Second Supervisor: Dr Eva Malone

Endometrial dysfunction as a result of Chlamydial infection

2016 - 2018
Megan Brown | Director of Studies: Dr Nick Wheelhouse | Second Supervisor: Prof Mick Rae

Characterisation of GABAA receptors and cation-chrloride cotransporters in the uterus and their role in pre-term labour

2015 - 2018
Melissa Sutherland | Director of Studies: Dr Amy Poole | Second Supervisor: Dr Jenny Fraser

The role of the cytoskeleton in autophagy and Crohn's disease

2014 - 2020
Olga Biskou | Director of Studies: Dr Craig Stevens | Second Supervisor: Prof Peter Barlow

Examining the nature of talent identification and development within a Nigerian context

2013 - 2016
Adeboye Elumaro | Director of Studies: Prof Russell Martindale | Second Supervisor: Dr Tony Westbury

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