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55 results

Dyslipidaemia and altered hepatic function in males - consequences of androgen excess in fetal life

Journal Article
Siemienowicz, K., Filis, P., Shaw, S., Douglas, A., Thomas, J., Howie, F., …Rae, M. (2019)
Dyslipidaemia and altered hepatic function in males - consequences of androgen excess in fetal life. Endocrine abstracts, 63, https://doi.org/10.1530/endoabs.63.P669
Introduction: Adult male offspring of women with PCOS have increased dyslipidaemia, characterised by elevated triglycerides (TG), increased total and LDL-cholesterol (LDL-C), ...

Fetal androgen exposure is a determinant of adult male metabolic health

Journal Article
Siemienowicz, K. J., Filis, P., Shaw, S., Douglas, A., Thomas, J., Mulroy, S., …Rae, M. T. (in press)
Fetal androgen exposure is a determinant of adult male metabolic health. Scientific Reports, 9, https://doi.org/10.1038/s41598-019-56790-4
Androgen signalling is a critical driver of male development. Fetal steroid signalling can be dysregulated by a range of environmental insults and clinical conditions. We hypo...

Urinary estrogens as a non-invasive biomarker of viable pregnancy in the giant panda (Ailuropoda melanoleuca)

Journal Article
Wilson, K. S., Wauters, J., Valentine, I., McNeilly, A., Girling, S., Li, R., …Duncan, W. C. (in press)
Urinary estrogens as a non-invasive biomarker of viable pregnancy in the giant panda (Ailuropoda melanoleuca). Scientific Reports, 9(1), https://doi.org/10.1038/s41598-019-49288-6
Female giant pandas show complex reproductive traits, being seasonally monoestrus, displaying a variable length embryonic diapause and exhibiting pseudopregnancy. Currently, t...

Urinary specific gravity as an alternative for the normalisation of endocrine metabolite concentrations in giant panda (Ailuropoda melanoleuca) reproductive monitoring

Journal Article
Wauters, J., Wilson, K. S., Bouts, T., Valentine, I., Vanderschueren, K., Ververs, C., …Vanhaecke, L. (2018)
Urinary specific gravity as an alternative for the normalisation of endocrine metabolite concentrations in giant panda (Ailuropoda melanoleuca) reproductive monitoring. PLOS ONE, 13(7), e0201420. https://doi.org/10.1371/journal.pone.0201420
Reproductive monitoring for captive breeding in giant pandas is based on behavioural observation and non-invasive hormone analysis. In urine, interpretation of results require...

Preferential activation of HIF-2α adaptive signalling in neuronal-like cells in response to acute hypoxia

Journal Article
Martín-Aragón Baudel, M. A. S., Rae, M. T., Darlison, M. G., Poole, A. V., & Fraser, J. A. (2017)
Preferential activation of HIF-2α adaptive signalling in neuronal-like cells in response to acute hypoxia. PLOS ONE, 12(10), e0185664. https://doi.org/10.1371/journal.pone.0185664
Stroke causes severe neuronal damage as disrupted cerebral blood flow starves neurons of oxygen and glucose. The hypoxia inducible factors (HIF-1α and HIF-2α) orchestrate oxyg...

Preferential activation of HIF-2 adaptive mechanisms in neuronal-like cells in response to hypoxia

Presentation / Conference
Fraser, J., Baudel, M., Rae, M., Darlison, M., & Poole, A. (2017, April)
Preferential activation of HIF-2 adaptive mechanisms in neuronal-like cells in response to hypoxia. Poster presented at British Neuroscience Association - festival of neuroscience 2017
Stroke is a leading cause of death and disability worldwide. Blockage, or occlusion, of cerebral arteries causes irreversible neuronal damage as disrupted blood flow starves n...

The expression of the chloride co-transporters NKCC1 and KCC2 is reversed in the penumbra following

Conference Proceeding
Baudel, M., Rae, M., Fraser, J., & Poole, A. (2017)
The expression of the chloride co-transporters NKCC1 and KCC2 is reversed in the penumbra following. In Brain and Neuroscience: BNA 2017 Festival of Neuroscience: Abstract Book
Stroke is one of the major causes of death and disability worldwide. The harm caused by the interruption of blood flow to the brain unfolds in the subsequent hours and days, s...

Development of in vitro strategies to predict in vivo toxicity of engineered nanoparticles to the male reproductive system.

Presentation / Conference
Malone, E., Ross, B., Rae, M., Bouwmeester, H., Gosens, I., Cassee, F., …Hutchison, G. (2016, September)
Development of in vitro strategies to predict in vivo toxicity of engineered nanoparticles to the male reproductive system. Poster presented at 11th International Particle Toxicology Conference, Singapore
The introduction of engineered nanomaterials (ENM) to new materials and products requires informed risk assessment. The altered physico-chemical properties of ENM mean traditi...

Exaggerated metabolic changes during puberty precede adult obesity and hyperlipidemia in an ovine model of Polycystic Ovary Syndrome (PCOS)

Presentation / Conference
Siemienowicz, K., Coukan, F., Lerner, A., Franks, S., Rae, M., & Duncan, C. (2016, July)
Exaggerated metabolic changes during puberty precede adult obesity and hyperlipidemia in an ovine model of Polycystic Ovary Syndrome (PCOS). Paper presented at Society for Reproduction and Fertility Annual Conference

Ovine trophoblasts express cathelicidin host defence peptide in response to infection

Journal Article
Coyle, C., Wheelhouse, N., Jacques, M., Longbottom, D., Svoboda, P., Pohl, J., …Barlow, P. G. (2016)
Ovine trophoblasts express cathelicidin host defence peptide in response to infection. Journal of Reproductive Immunology, 117, 10-16. https://doi.org/10.1016/j.jri.2016.06.006
Cationic host defence peptides (CHDP; also known as antimicrobial peptides) are key components of the immune response in the female reproductive tract. The role of the placent...

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5 results

Can exposure to excess androgen during fetal life increase risk of hepatic disease in male offspring?

2019 - 2019
Background Polycystic ovary syndrome (PCOS) is a common condition. Hyperandrogenaemia characterises PCOS, and is considered an ‘in utero environmental programmer’ of PCOS in female offspring. Male o...
Funder: Society for Reproduction and Fertility | Value: £3,000

Gender-specific disease development due to developmental steroid insults: mechanistic understanding and biomarker development as routes towards prevention of disease.

2017 - 2021
Risks of developing many adult illnesses are set down as we develop in the womb, hence the environment we experience during fetal life needs to be ‘just right’. Understanding how the fetal environmen...
Funder: Medical Research Council | Value: £636,509

Does the gut microbiome play a role in polycystic ovary syndrome?

2017 - 2018
Does the gut microbiome play a role in polycystic ovary syndrome?
Funder: Society for Reproduction and Fertility | Value: £12,250

PCOS and Thyroid dysfunction

2015 - 2015
Undergraduate vacation scholarship application to study the legacy of prenatal programming of polycystic ovary syndrome on postnatal throid function
Funder: Society for Reproduction and Fertility | Value: £2,750

Polycystic ovary syndrome (PCOS) developmental model

2010 - 2014
Polycystic ovary syndrome (PCOS) is common: more than one in 1 in 15 young women has this condition. There are many associated health problems including abnormal periods, miscarriages, infertility, ex...
Funder: Medical Research Council | Value: £130,956
15 results

Gender differences and STEM subjects: the role of professional role confidence and gender identity

2017 - date
Kamila Krol | Director of Studies: Dr Tony Westbury | Second Supervisor: Dr Sally Brown

The hepatic health legacy of prenatal androgen excess in male adolescence

2017 - date
Jennifer Mcgeachie | Director of Studies: Prof Mick Rae | Second Supervisor: Dr Amy Poole

Fatigue and the mind-body relation: A Lacanian exploration

2016 - date
This PhD project aims to explore the role of discourse in the formation and manifestation of symptoms related to the condition Chronic Fatigue...
Amanda Diserholt | Director of Studies: Dr Calum Neill | Second Supervisor: Adele Dickson

Performance in enduro mountain biking: the influence of training status, recovery and vibration

2016 - 2019
This PhD project is to investigate the physiological demands of elite enduro mountain bike racing. Previ...
Dr Lewis Kirkwood | Director of Studies: Prof Geraint Florida-James | Second Supervisor: Dr Eva Malone

Endometrial dysfunction as a result of Chlamydial infection

2016 - 2018
Megan Brown | Director of Studies: Dr Nick Wheelhouse | Second Supervisor: Prof Mick Rae

Analysing the physiological and molecular mechanisms of metastasis inhibition by Kisspeptins

2016 - 2018
Miguel Hernandez Madrigal | Director of Studies: Dr Sharron Vass | Second Supervisor: Prof Mick Rae

Characterisation of GABAA receptors and cation-chrloride cotransporters in the uterus and their role in pre-term labour

2015 - 2018
Melissa Sutherland | Director of Studies: Dr Amy Poole | Second Supervisor: Dr Jenny Fraser

The role of the cytoskeleton in autophagy and Crohn's disease

2014 - date
Olga Biskou | Director of Studies: Dr Craig Stevens | Second Supervisor: Prof Peter Barlow

The roles and regulation of cationic host defence peptides in normal and compromised pregnancies

2013 - 2016
Chris Coyle | Director of Studies: Prof Peter Barlow | Second Supervisor: Prof Mick Rae

The role of gamma-aminobutyric acid type A (GABA-A) receptor and cation chloride co-transporters (CCCs) as possible neuroprotective targets in stroke

2013 - 2018
This doctoral research project is concerned with th...
Miguel Ángel Stanislas Martín-Aragón Baudel | Director of Studies: Dr Amy Poole | Second Supervisor: Dr Jenny Fraser

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