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Wattegedera, S. R., Doull, L. E., Goncheva, M. I., Wheelhouse, N., Watson, D. M., Pearce, J., …Entrican, G. (in press). Immunological homeostasis at the ovine placenta may reflect the degree of maternal foetal interaction. Frontiers in Immunology,
Successful mammalian pregnancies are a result of complex physiological, endocrinological and immunological processes that combine to create an environment where the mother is ...
Flach, E. J., Dagleish, M. P., Feltrer, Y., Gill, I. S., Marschang, R. E., Masters, N., …Wheelhouse, N. M. (in press). Ferlavirus-related deaths in a collection of viperid snakes. Journal of Zoo and Wildlife Medicine,
Between June and October 2013 26 snakes of six viperid species kept in two adjoining rooms died (n = 16) or were euthanized on medical (1) or welfare grounds (9). Two were fro...
Ahmad, S. F., Brown, J. K., Campbell, L. L., Koscielniak, M., Oliver, C., Wheelhouse, N., …Horne, A. W. (2018). Pelvic Chlamydial Infection Predisposes to Ectopic Pregnancy by Upregulating Integrin β1 to Promote Embryo-tubal Attachment. EBioMedicine, doi:10.1016/j.ebiom.2018.02.020
Tubal ectopic pregnancies are a leading cause of global maternal morbidity and mortality. Previous infection with Chlamydia trachomatis is a major risk factor for tubal embryo...
Department for Business, Energy & Industrial Strategy
Rutherford Fellows, will work in project areas related to food safety (Pathogen detection, AMR etc) and food spoilage.
Rutherford Fund, are funded by BEIS and the scheme is being managed by Universit...
Society for Reproduction and Fertility
SRF summer studentship
Chlamydia trachomatis is the most common sexually-transmitted infection in the world, and is associated with miscarriage, pre-term birth and infertility. However, the understanding of the mechanisms t...
Parsonage, B., Hagglund, P. K., Keogh, L., Wheelhouse, N., Brown, R. E., & Dancer, S. J. (2017). Control of Antimicrobial Resistance Requires an Ethical Approach. Frontiers in Microbiology, 8, doi:10.3389/fmicb.2017.02124
Ethical behavior encompasses actions that benefit both self and society. This means that tackling antimicrobial resistance (AMR) becomes an ethical obligation, because the pro...
Velasova, M., Damaso, A., Prakashbabu, B. C., Gibbons, J., Wheelhouse, N., Longbottom, D., …Guitian, J. (2017). Herd-level prevalence of selected endemic infectious diseases of dairy cows in Great Britain. Journal of Dairy Science, 100(11), (9215-9233). doi:10.3168/jds.2016-11863. ISSN 0022-0302
n order to implement appropriate and effective disease control programs at national level, up-to-date and unbiased information on disease frequency is needed. The aim of this...
Chlamydia trachomatis infection of human endometrial stromal cells induces defective decidualisation and chemokine release. Scientific Reports, 7(1), doi:10.1038/s41598-017-02223-z
Miscarriage affects ~20% of pregnancies and 30 maternal infections account for ~15% of early miscarriages. Chlamydia trachomatis (Ct) has been associated with miscarriage but ...
Livingstone, M., Wheelhouse, N., Ensor, H., Rocchi, M., Maley, S., Aitchison, K., …Longbottom, D. (2017). Pathogenic outcome following experimental infection of sheep with Chlamydia abortus variant strains LLG and POS. PLoS ONE, 12(5), (e0177653). doi:10.1371/journal.pone.0177653. ISSN 1932-6203
This study investigated the pathogenesis of two variant strains (LLG and POS) of Chlamydia abortus, in comparison to a typical wild-type strain (S26/3) which is known to be re...
Wheelhouse, N., Flockhart, A., Aitchison, K., Livingstone, M., Finlayson, J., Flachon, V., …Longbottom, D. (2016). Experimental challenge of pregnant cattle with the putative abortifacient Waddlia chondrophila. Scientific Reports. 6, 37150. doi:10.1038/srep37150. ISSN 2045-2322
Waddlia chondrophila is a Gram-negative intracellular bacterial organism that is related to classical chlamydial species and has been implicated as a cause of abortion in catt...
Özkan, Ş., Vitali, A., Lacetera, N., Amon, B., Bannink, A., Bartley, D. J., …Kipling, R. P. (2016). Challenges and priorities for modelling livestock health and pathogens in the context of climate change. Environmental Research. 151, 130-144. doi:10.1016/j.envres.2016.07.033. ISSN 0013-9351
Climate change has the potential to impair livestock health, with consequences for animal welfare, productivity, greenhouse gas emissions, and human livelihoods and health. Mo...
Barlow, P. G., Coyle, C., Wheelhouse, N., Jacques, M., Longbottom, D., Svoboda, P., …Colin Duncan, W. (2016). Ovine trophoblasts express cathelicidin host defence peptide in response to infection. Journal of Reproductive Immunology. 117, 10-16. doi:10.1016/j.jri.2016.06.006. ISSN 0165-0378
Cationic host defence peptides (CHDP; also known as antimicrobial peptides) are key components of the immune response in the female reproductive tract. The role of the placent...
Storrie, S., Longbottom, D., Barlow, P. G., & Wheelhouse, N. (2016). MAPK Activation Is Essential for Waddlia chondrophila Induced CXCL8 Expression in Human Epithelial Cells. PLoS ONE, 11(3), (e0152193). doi:10.1371/journal.pone.0152193. ISSN 1932-6203
Waddlia chondrophila (W. chondrophila) is an emerging agent of respiratory and reproductive disease in humans and cattle. The organism is a member of the order Chla...
Giakoumelou, S., Wheelhouse, N., Cuschieri, K., Entrican, G., Howie, S. E., & Horne, A. W. (2016). The role of infection in miscarriage. Human Reproduction Update, 22(1), (116-133). doi:10.1093/humupd/dmv041. ISSN 1355-4786
BACKGROUND: Miscarriage is the spontaneous loss of a pregnancy before 12 weeks (early miscarriage) or from 12 to 24 weeks (late miscarriage) of gestation. Miscarriage occurs i...
Wheelhouse, N., Mearns, R., Willoughby, K., Wright, E., Turnbull, D. & Longbottom, D. (2015). Evidence of members of the Chlamydiales in bovine abortions in England and Wales. Veterinary Record. 176, 465. doi:10.1136/vr.103075. ISSN 0042-4900
Wheelhouse, N. & Longbottom, D. (2015). Chlamydia-related Organisms: Infection in Ruminants and Potential for Zoonotic transmission. Current Clinical Microbiology Reports. 2(1), 1-9. doi:10.1007/s40588-014-0011-x. ISSN 2196-5471
Cope, I., Wheelhouse, N., Pocknell, A., Dagleish, M. & Summers, B. (2014). An unusual presentation ofChlamydia pneumoniaeinfection in a Royal Python (Python regius). Veterinary record case reports. 2(1), e000086. doi:10.1136/vetreccr-2014-000086. ISSN 2052-6121
Scottish Funding Council
Development of a UV-C hand-sanitiser unit
Chief Scientists Office
Chlamydia trachomatis is the most common sexually transmitted infection in Scotland, and has significant long‐term consequences to reproductive health. Recent studies suggest that in addition to the g...
University of Glasgow
Supporting Evidence Based Interventions
Listeria monocytogenes is a ubiquitous environmental bacterium which has the potential to cause serious illness and even death afte...