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Research Centres Groups : Biomedical Science Research Group x Research Areas : Reproductive health x Themes : Wellbeing x

People (6)

Outputs (26)

Understanding the attitudes and acceptability of extra-genital Chlamydia testing in young women: evaluation of a feasibility study

Brown, S., Paterson, C., Dougall, N., Cameron, S., & Wheelhouse, N. (in press). Understanding the attitudes and acceptability of extra-genital Chlamydia testing in young women: evaluation of a feasibility study. BMC Public Health, 19(1), https://doi.org/10.1186/s12889-019-7313-0
Brown, S., Paterson, C., Dougall, N., Cameron, S., & Wheelhouse, N. (in press). Understanding the attitudes and acceptability of extra-genital Chlamydia testing in young women: evaluation of a feasibility study. BMC Public Health, 19(1), https://doi.org/10.1186/s12889-019-7313-0

Background Chlamydia trachomatis (C. trachomatis) is the most common bacterial sexually transmitted infection in the UK. Recent studies suggest that in addition to the genital...

2019
Immunological homeostasis at the ovine placenta may reflect the degree of maternal foetal interaction

Wattegedera, S. R., Doull, L. E., Goncheva, M. I., Wheelhouse, N., Watson, D. M., Pearce, J., …Entrican, G. (2019). Immunological homeostasis at the ovine placenta may reflect the degree of maternal foetal interaction. Frontiers in Immunology, 9, https://doi.org/10.3389/fimmu.2018.03025
Wattegedera, S. R., Doull, L. E., Goncheva, M. I., Wheelhouse, N., Watson, D. M., Pearce, J., …Entrican, G. (2019). Immunological homeostasis at the ovine placenta may reflect the degree of maternal foetal interaction. Frontiers in Immunology, 9, https://doi.org/10.3389/fimmu.2018.03025

Successful mammalian pregnancies are a result of complex physiological, endocrinological and immunological processes that combine to create an environment where the mother is ...

2019
Ferlavirus-related deaths in a collection of viperid snakes

Flach, E. J., Dagleish, M. P., Feltrer, Y., Gill, I. S., Marschang, R. E., Masters, N., …Wheelhouse, N. M. (2018). Ferlavirus-related deaths in a collection of viperid snakes. Journal of Zoo and Wildlife Medicine, 49(4), 983-995. https://doi.org/10.1638/2017-0223.1
Flach, E. J., Dagleish, M. P., Feltrer, Y., Gill, I. S., Marschang, R. E., Masters, N., …Wheelhouse, N. M. (2018). Ferlavirus-related deaths in a collection of viperid snakes. Journal of Zoo and Wildlife Medicine, 49(4), 983-995. https://doi.org/10.1638/2017-0223.1

Between June and October 2013 26 snakes of six viperid species kept in two adjoining rooms died (n = 16) or were euthanized on medical (1) or welfare grounds (9). Two were fro...

2018
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Projects (9)

Research Centres Groups : Biomedical Science Research Group x Research Areas : Reproductive health x Themes : Wellbeing x

Understanding the attitudes and acceptability of extra-genital Chlamydia testing in young women: evaluation of a feasibility study

Brown, S., Paterson, C., Dougall, N., Cameron, S., & Wheelhouse, N. (in press). Understanding the attitudes and acceptability of extra-genital Chlamydia testing in young women: evaluation of a feasibility study. BMC Public Health, 19(1), https://doi.org/10.1186/s12889-019-7313-0
Brown, S., Paterson, C., Dougall, N., Cameron, S., & Wheelhouse, N. (in press). Understanding the attitudes and acceptability of extra-genital Chlamydia testing in young women: evaluation of a feasibility study. BMC Public Health, 19(1), https://doi.org/10.1186/s12889-019-7313-0

Background Chlamydia trachomatis (C. trachomatis) is the most common bacterial sexually transmitted infection in the UK. Recent studies suggest that in addition to the genital...

2019
Immunological homeostasis at the ovine placenta may reflect the degree of maternal foetal interaction

Wattegedera, S. R., Doull, L. E., Goncheva, M. I., Wheelhouse, N., Watson, D. M., Pearce, J., …Entrican, G. (2019). Immunological homeostasis at the ovine placenta may reflect the degree of maternal foetal interaction. Frontiers in Immunology, 9, https://doi.org/10.3389/fimmu.2018.03025
Wattegedera, S. R., Doull, L. E., Goncheva, M. I., Wheelhouse, N., Watson, D. M., Pearce, J., …Entrican, G. (2019). Immunological homeostasis at the ovine placenta may reflect the degree of maternal foetal interaction. Frontiers in Immunology, 9, https://doi.org/10.3389/fimmu.2018.03025

Successful mammalian pregnancies are a result of complex physiological, endocrinological and immunological processes that combine to create an environment where the mother is ...

2019
Ferlavirus-related deaths in a collection of viperid snakes

Flach, E. J., Dagleish, M. P., Feltrer, Y., Gill, I. S., Marschang, R. E., Masters, N., …Wheelhouse, N. M. (2018). Ferlavirus-related deaths in a collection of viperid snakes. Journal of Zoo and Wildlife Medicine, 49(4), 983-995. https://doi.org/10.1638/2017-0223.1
Flach, E. J., Dagleish, M. P., Feltrer, Y., Gill, I. S., Marschang, R. E., Masters, N., …Wheelhouse, N. M. (2018). Ferlavirus-related deaths in a collection of viperid snakes. Journal of Zoo and Wildlife Medicine, 49(4), 983-995. https://doi.org/10.1638/2017-0223.1

Between June and October 2013 26 snakes of six viperid species kept in two adjoining rooms died (n = 16) or were euthanized on medical (1) or welfare grounds (9). Two were fro...

2018
Urinary specific gravity as an alternative for the normalisation of endocrine metabolite concentrations in giant panda (Ailuropoda melanoleuca) reproductive monitoring

Wauters, J., Wilson, K. S., Bouts, T., Valentine, I., Vanderschueren, K., Ververs, C., …Vanhaecke, L. (2018). Urinary specific gravity as an alternative for the normalisation of endocrine metabolite concentrations in giant panda (Ailuropoda melanoleuca) reproductive monitoring. PLOS ONE, 13(7), e0201420. https://doi.org/10.1371/journal.pone.0201420
Wauters, J., Wilson, K. S., Bouts, T., Valentine, I., Vanderschueren, K., Ververs, C., …Vanhaecke, L. (2018). Urinary specific gravity as an alternative for the normalisation of endocrine metabolite concentrations in giant panda (Ailuropoda melanoleuca) reproductive monitoring. PLOS ONE, 13(7), e0201420. https://doi.org/10.1371/journal.pone.0201420

Reproductive monitoring for captive breeding in giant pandas is based on behavioural observation and non-invasive hormone analysis. In urine, interpretation of results require...

2018
Pelvic Chlamydial Infection Predisposes to Ectopic Pregnancy by Upregulating Integrin β1 to Promote Embryo-tubal Attachment

Ahmad, S. F., Brown, J. K., Campbell, L. L., Koscielniak, M., Oliver, C., Wheelhouse, N., …Horne, A. W. (2018). Pelvic Chlamydial Infection Predisposes to Ectopic Pregnancy by Upregulating Integrin β1 to Promote Embryo-tubal Attachment. EBioMedicine, https://doi.org/10.1016/j.ebiom.2018.02.020
Ahmad, S. F., Brown, J. K., Campbell, L. L., Koscielniak, M., Oliver, C., Wheelhouse, N., …Horne, A. W. (2018). Pelvic Chlamydial Infection Predisposes to Ectopic Pregnancy by Upregulating Integrin β1 to Promote Embryo-tubal Attachment. EBioMedicine, https://doi.org/10.1016/j.ebiom.2018.02.020

Tubal ectopic pregnancies are a leading cause of global maternal morbidity and mortality. Previous infection with Chlamydia trachomatis is a major risk factor for tubal embryo...

2018
Herd-level prevalence of selected endemic infectious diseases of dairy cows in Great Britain

Velasova, M., Damaso, A., Prakashbabu, B. C., Gibbons, J., Wheelhouse, N., Longbottom, D., …Guitian, J. (2017). Herd-level prevalence of selected endemic infectious diseases of dairy cows in Great Britain. Journal of Dairy Science, 100(11), 9215-9233. https://doi.org/10.3168/jds.2016-11863
Velasova, M., Damaso, A., Prakashbabu, B. C., Gibbons, J., Wheelhouse, N., Longbottom, D., …Guitian, J. (2017). Herd-level prevalence of selected endemic infectious diseases of dairy cows in Great Britain. Journal of Dairy Science, 100(11), 9215-9233. https://doi.org/10.3168/jds.2016-11863

To implement appropriate and effective disease control programs at national level, up-to-date and unbiased information on disease frequency is needed. The aim of this study w...

2017
Chlamydia trachomatis infection of human endometrial stromal cells induces defective decidualisation and chemokine release

Giakoumelou, S., Wheelhouse, N., Brown, J., Wade, J., Simitsidellis, I., Gibson, D., …Horne, A. W. (2017). Chlamydia trachomatis infection of human endometrial stromal cells induces defective decidualisation and chemokine release. Scientific Reports, 7(1), https://doi.org/10.1038/s41598-017-02223-z
Giakoumelou, S., Wheelhouse, N., Brown, J., Wade, J., Simitsidellis, I., Gibson, D., …Horne, A. W. (2017). Chlamydia trachomatis infection of human endometrial stromal cells induces defective decidualisation and chemokine release. Scientific Reports, 7(1), https://doi.org/10.1038/s41598-017-02223-z

Miscarriage affects ~20% of pregnancies and 30 maternal infections account for ~15% of early miscarriages. Chlamydia trachomatis (Ct) has been associated with miscarriage but ...

2017
Pathogenic outcome following experimental infection of sheep with Chlamydia abortus variant strains LLG and POS

Livingstone, M., Wheelhouse, N., Ensor, H., Rocchi, M., Maley, S., Aitchison, K., …Longbottom, D. (2017). Pathogenic outcome following experimental infection of sheep with Chlamydia abortus variant strains LLG and POS. PLOS ONE, 12(5), e0177653. https://doi.org/10.1371/journal.pone.0177653
Livingstone, M., Wheelhouse, N., Ensor, H., Rocchi, M., Maley, S., Aitchison, K., …Longbottom, D. (2017). Pathogenic outcome following experimental infection of sheep with Chlamydia abortus variant strains LLG and POS. PLOS ONE, 12(5), e0177653. https://doi.org/10.1371/journal.pone.0177653

This study investigated the pathogenesis of two variant strains (LLG and POS) of Chlamydia abortus, in comparison to a typical wild-type strain (S26/3) which is known to be re...

2017
Experimental challenge of pregnant cattle with the putative abortifacient Waddlia chondrophila

Wheelhouse, N., Flockhart, A., Aitchison, K., Livingstone, M., Finlayson, J., Flachon, V., …Longbottom, D. (2016). Experimental challenge of pregnant cattle with the putative abortifacient Waddlia chondrophila. Scientific Reports, 6, 37150. https://doi.org/10.1038/srep37150
Wheelhouse, N., Flockhart, A., Aitchison, K., Livingstone, M., Finlayson, J., Flachon, V., …Longbottom, D. (2016). Experimental challenge of pregnant cattle with the putative abortifacient Waddlia chondrophila. Scientific Reports, 6, 37150. https://doi.org/10.1038/srep37150

Waddlia chondrophila is a Gram-negative intracellular bacterial organism that is related to classical chlamydial species and has been implicated as a cause of abortion in catt...

2016
Ovine trophoblasts express cathelicidin host defence peptide in response to infection

Coyle, C., Wheelhouse, N., Jacques, M., Longbottom, D., Svoboda, P., Pohl, J., …Barlow, P. G. (2016). Ovine trophoblasts express cathelicidin host defence peptide in response to infection. Journal of Reproductive Immunology, 117, 10-16. https://doi.org/10.1016/j.jri.2016.06.006
Coyle, C., Wheelhouse, N., Jacques, M., Longbottom, D., Svoboda, P., Pohl, J., …Barlow, P. G. (2016). Ovine trophoblasts express cathelicidin host defence peptide in response to infection. Journal of Reproductive Immunology, 117, 10-16. https://doi.org/10.1016/j.jri.2016.06.006

Cationic host defence peptides (CHDP; also known as antimicrobial peptides) are key components of the immune response in the female reproductive tract. The role of the placent...

2016
Androgen action in the masculinization programming window and development of male reproductive organs

MacLeod, D. J., Sharpe, R. M., Welsh, M., Fisken, M., Scott, H. M., Hutchison, G. R., …van den Driesche, S. (2010). Androgen action in the masculinization programming window and development of male reproductive organs. International Journal of Andrology, 33(2), 279-287. https://doi.org/10.1111/j.1365-2605.2009.01005.x
MacLeod, D. J., Sharpe, R. M., Welsh, M., Fisken, M., Scott, H. M., Hutchison, G. R., …van den Driesche, S. (2010). Androgen action in the masculinization programming window and development of male reproductive organs. International Journal of Andrology, 33(2), 279-287. https://doi.org/10.1111/j.1365-2605.2009.01005.x

We have shown previously that deficient androgen action within a masculinization programming window (MPW; e15.5–e18.5 in rats) is important in the origin of male reproductive ...

2010
A critical review of the biological mechanisms underlying the in vivo and in vitro toxicity of carbon nanotubes: The contribution of physico-chemical characteristics

Johnston, H. J., Hutchison, G. R., Christensen, F. M., Peters, S., Hankin, S., Aschberger, K., & Stone, V. (2010). A critical review of the biological mechanisms underlying the in vivo and in vitro toxicity of carbon nanotubes: The contribution of physico-chemical characteristics. Nanotoxicology, 4(2), 207-246. https://doi.org/10.3109/17435390903569639
Johnston, H. J., Hutchison, G. R., Christensen, F. M., Peters, S., Hankin, S., Aschberger, K., & Stone, V. (2010). A critical review of the biological mechanisms underlying the in vivo and in vitro toxicity of carbon nanotubes: The contribution of physico-chemical characteristics. Nanotoxicology, 4(2), 207-246. https://doi.org/10.3109/17435390903569639

This critical review of the available human health safety data, relating to carbon nanotubes (CNTs), was conducted in order to assess the risks associated with CNT exposure. D...

2010
A review of the in vivo and in vitro toxicity of silver and gold particulates: Particle attributes and biological mechanisms responsible for the observed toxicity

Johnston, H. J., Hutchison, G., Christensen, F. M., Peters, S., Hankin, S., & Stone, V. (2010). A review of the in vivo and in vitro toxicity of silver and gold particulates: Particle attributes and biological mechanisms responsible for the observed toxicity. Critical Reviews in Toxicology, 40(4), 328-346. https://doi.org/10.3109/10408440903453074
Johnston, H. J., Hutchison, G., Christensen, F. M., Peters, S., Hankin, S., & Stone, V. (2010). A review of the in vivo and in vitro toxicity of silver and gold particulates: Particle attributes and biological mechanisms responsible for the observed toxicity. Critical Reviews in Toxicology, 40(4), 328-346. https://doi.org/10.3109/10408440903453074

This review is concerned with evaluating the toxicity associated with human exposure to silver and gold nanoparticles (NPs), due to the relative abundance of toxicity data ava...

2010
Identification of the mechanisms that drive the toxicity of TiO2 particulates: the contribution of physicochemical characteristics

Johnston, H. J., Hutchison, G. R., Christensen, F. M., Peters, S., Hankin, S., & Stone, V. (2009). Identification of the mechanisms that drive the toxicity of TiO2 particulates: the contribution of physicochemical characteristics. Particle and fibre toxicology, 6(1), 33. https://doi.org/10.1186/1743-8977-6-33
Johnston, H. J., Hutchison, G. R., Christensen, F. M., Peters, S., Hankin, S., & Stone, V. (2009). Identification of the mechanisms that drive the toxicity of TiO2 particulates: the contribution of physicochemical characteristics. Particle and fibre toxicology, 6(1), 33. https://doi.org/10.1186/1743-8977-6-33

This review focuses on outlining the toxicity of titanium dioxide (TiO₂) particulates in vitro and in vivo, in order to understand their ability to detrimentally impact...

2009
Glucocorticoids Amplify Dibutyl Phthalate-Induced Disruption of Testosterone Production and Male Reproductive Development

Drake, A. J., van den Driesche, S., Scott, H. M., Hutchison, G. R., Seckl, J. R., & Sharpe, R. M. (2009). Glucocorticoids Amplify Dibutyl Phthalate-Induced Disruption of Testosterone Production and Male Reproductive Development. Endocrinology, 150(11), 5055-5064. https://doi.org/10.1210/en.2009-0700
Drake, A. J., van den Driesche, S., Scott, H. M., Hutchison, G. R., Seckl, J. R., & Sharpe, R. M. (2009). Glucocorticoids Amplify Dibutyl Phthalate-Induced Disruption of Testosterone Production and Male Reproductive Development. Endocrinology, 150(11), 5055-5064. https://doi.org/10.1210/en.2009-0700

Common male reproductive abnormalities including cryptorchidism, hypospadias, and low sperm counts may comprise a testicular dysgenesis syndrome (TDS), resulting from fetal te...

2009

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Research Centres Groups : Biomedical Science Research Group x Research Areas : Reproductive health x Themes : Wellbeing x

Staff directory

People (6)

Prof Peter Barlow

Prof Gary Hutchison

Dr Nick Wheelhouse

Outputs (26)

Understanding the attitudes and acceptability of extra-genital Chlamydia testing in young women: evaluation of a feasibility study

Immunological homeostasis at the ovine placenta may reflect the degree of maternal foetal interaction

Ferlavirus-related deaths in a collection of viperid snakes

Projects (9)

Can exposure to excess androgen during fetal life increase risk of hepatic disease in male offspring?

Rutherford fund Strategic Partner Grant

Direct and paracrine effects of Chlamydia infection on decidualisation of endometrial stromal cells

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School

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Themes

Prof Peter Barlow

Prof Gary Hutchison

Dr Janis MacCallum

Prof Mick Rae

Dr Kasia Siemienowicz

Dr Nick Wheelhouse

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Understanding the attitudes and acceptability of extra-genital Chlamydia testing in young women: evaluation of a feasibility study

Immunological homeostasis at the ovine placenta may reflect the degree of maternal foetal interaction

Ferlavirus-related deaths in a collection of viperid snakes

Urinary specific gravity as an alternative for the normalisation of endocrine metabolite concentrations in giant panda (Ailuropoda melanoleuca) reproductive monitoring

Pelvic Chlamydial Infection Predisposes to Ectopic Pregnancy by Upregulating Integrin β1 to Promote Embryo-tubal Attachment

Herd-level prevalence of selected endemic infectious diseases of dairy cows in Great Britain

Chlamydia trachomatis infection of human endometrial stromal cells induces defective decidualisation and chemokine release

Pathogenic outcome following experimental infection of sheep with Chlamydia abortus variant strains LLG and POS

Experimental challenge of pregnant cattle with the putative abortifacient Waddlia chondrophila

Ovine trophoblasts express cathelicidin host defence peptide in response to infection

Androgen action in the masculinization programming window and development of male reproductive organs

A critical review of the biological mechanisms underlying the in vivo and in vitro toxicity of carbon nanotubes: The contribution of physico-chemical characteristics

A review of the in vivo and in vitro toxicity of silver and gold particulates: Particle attributes and biological mechanisms responsible for the observed toxicity

Identification of the mechanisms that drive the toxicity of TiO2 particulates: the contribution of physicochemical characteristics

Glucocorticoids Amplify Dibutyl Phthalate-Induced Disruption of Testosterone Production and Male Reproductive Development

Date

Research Centres Groups

School

Research Areas

Themes

People

Can exposure to excess androgen during fetal life increase risk of hepatic disease in male offspring?

Rutherford fund Strategic Partner Grant

Direct and paracrine effects of Chlamydia infection on decidualisation of endometrial stromal cells

Mechanism of Chlamydia induced progesterone resistance

Development of a UV-C hand-sanitiser unit

Gender-specific disease development due to developmental steroid insults: mechanistic understanding and biomarker development as routes towards prevention of disease.

Does the gut microbiome play a role in polycystic ovary syndrome?

PCOS and Thyroid dysfunction

Polycystic ovary syndrome (PCOS) developmental model

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The Effects of Air Pollution Particles on Clearance Mechanisms within the Lung - Prof Peter Barlow, Vicki Stone

The Toxicological Effects of PM10 Components On Lung Cells - Prof Gary Hutchison

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