Yu, Y., Tangney, M., Aass, H. C. & Mitchell, W. J. (2007). Analysis of the mechanism and regulation of lactose transport and metabolism in Clostridium acetobutylicum ATCC 824. Applied and Environmental Microbiology. 73, 1842-1850. doi:10.1128/AEM.02082-06. ISSN 0099-2240
Although the acetone-butanol-ethanol (ABE) fermentation of Clostridium acetobutylicum is currently uneconomic, the ability of the bacterium to metabolise a wide range of carbo...
Tangney, M. & Mitchell, W. J. (2007). Characterisation of a glucose phosphotransferase system in Clostridium acetobutylicum ATCC 824. Applied microbiology and biotechnology. 74, 398-405. doi:10.1007/s00253-006-0679-9. ISSN 1432-0614
The transport of glucose by the solventogenic anaerobe Clostridium acetobutylicum was investigated. Glucose phosphoenolpyruvate (PEP)-dependent phosphotransferase system (PTS)...
Lee, J., Mitchell, W. J., Tangney, M. & Blaschek, H. P. (2005). Evidence for the presence of an alternative glucose transport system in Clostridium beijerinckii NCIMB 8052 and the solvent hyper-producing mutant BA101. Applied and Environmental Microbiology. 71, 3384-3387. doi:10.1128/AEM.71.6.3384-3387.2005. ISSN 0099-2240
The effects of substrate analogs and energy inhibitors on glucose uptake and phosphorylation by Clostridium beijerinckii provide evidence for the operation of two uptake syste...
University of Stratchlyde (Industrial Biotechnology Innovation Centre)
This project aims to investigate the first phase to manufacture chemicals from starch waste, namely acetone, butanol, ethanol, succinic acid and/or D-amino acid oxidase. Edinburgh Napier University (E...
This is an application for a prestigious ETP Energy Industry Doctorate in Renewable Energy Technologies (SFC funding) in partnership with Celtic Renewables Ltd. The project will investigate various a...
Analysis, support and development of the patented ABE Fermentation Process
Mitchell, W. J., & Tangney, M. (2004). Carbohydrate uptake by the phosphotransferase system and other mechanisms. In P. Durre (Ed.), Handbook on Clostridia, 583-606. CRC Press
Tangney, M., & Mitchell, W. J. (2004). Regulation of catabolic gene systems. In P. Durre (Ed.), Handbook on clostridia, 583-606. CRC Press
Tangney, M., Deutscher, J., Galinier, A. & Mitchell, W. J. (2003). Analysis of the elements of catabolite repression in Clostridium acetobutylicum. Journal of Molecular Microbiology and Biotechnology. 6, 6-11. doi:10.1159/000073403. ISSN 1464-1801
The ptsH gene, encoding the phosphotransferase protein HPr, from Clostridium acetobutylicum ATCC 824 was identified from the genome sequence, cloned and shown to complement a ...
Tangney, M. & White, J. S. (2007). Biofuels - the solution for the future is in the past: history of butanol fermentation and its application as a biofuel. The Brewer and Distiller International. 4, 53-55
Biofuels Development Programme
Scottish Funding Council
Biotechnology and Biological Sciences Research Council
An investigation of sugar uptake and metabolism in relation to biobutanol production by solventogenic clostridia
Fossil fuels are a finite resource, which are subject to erratic price fluctuations and are c...
In low GC Gram-positive bacteria, the phenomenon of carbon catabolite repression is dependent on a me...