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238 results

Putting a balance on the aerosolization debate around SARS-CoV-2

Journal Article
Dancer, S. J., Tang, J. W., Marr, L. C., Miller, S., Morawska, L., & Jimenez, J. L. (in press)
Putting a balance on the aerosolization debate around SARS-CoV-2. Journal of Hospital Infection, https://doi.org/10.1016/j.jhin.2020.05.014
No abstract available.

Precision Medicine and the Role of Biomarkers of Radiotherapy Response in Breast Cancer

Journal Article
Meehan, J., Gray, M., Martínez-Pérez, C., Kay, C., Pang, L. Y., Fraser, J. A., …Turnbull, A. K. (2020)
Precision Medicine and the Role of Biomarkers of Radiotherapy Response in Breast Cancer. Frontiers in Oncology, 10, https://doi.org/10.3389/fonc.2020.00628
Radiotherapy remains an important treatment modality in nearly two thirds of all cancers, including the primary curative or palliative treatment of breast cancer. Unfortunatel...

Bacterial Transfer To Fingertips During Sequential Surface Contacts With And Without Gloves

Journal Article
King, M., López‐García, M., Atedoghu, K. P., Zhang, N., Wilson, A. M., Weterings, M., …Fletcher, L. A. (in press)
Bacterial Transfer To Fingertips During Sequential Surface Contacts With And Without Gloves. Indoor Air, https://doi.org/10.1111/ina.12682
Bacterial transmission from contaminated surfaces via hand contact plays a critical role in disease spread. However, the fomite‐to‐finger transfer efficiency of microorganisms...

Reducing hand recontamination of healthcare workers during COVID-19

Journal Article
Gon, G., Dancer, S., Dreibelbis, R., Graham, W. J., & Kilpatrick, C. (in press)
Reducing hand recontamination of healthcare workers during COVID-19. Infection Control and Hospital Epidemiology, https://doi.org/10.1017/ice.2020.111
No abstract available.

Dynamic Transmission of Staphylococcus Aureus in the Intensive Care Unit

Journal Article
Adams, C. E., & Dancer, S. J. (2020)
Dynamic Transmission of Staphylococcus Aureus in the Intensive Care Unit. International Journal of Environmental Research and Public Health, 17(6), https://doi.org/10.3390/ijerph17062109
Staphylococcus aureus is an important bacterial pathogen. This study utilized known staphylococcal epidemiology to track S. aureus between patients, surfaces, staff hands and ...

Revising Nightingale's legacy

Journal Article
Dancer, S. (2020)
Revising Nightingale's legacy. Journal of Hospital Infection, https://doi.org/10.1016/j.jhin.2020.03.016
The recent editorial from this Journal does well to highlight the benefits of hand hygiene once again [ 1 ]. It is entirely appropriate to support the need for clean hands, es...

Measuring environmental contamination in critical care using dilute hydrogen peroxide (DHP) technology: An observational cross-over study

Journal Article
Oon, A., Reading, E., Ferguson, J., Dancer, S., & Mitchell, B. (2020)
Measuring environmental contamination in critical care using dilute hydrogen peroxide (DHP) technology: An observational cross-over study. Infection, Disease & Health, 25(2), 107-112. https://doi.org/10.1016/j.idh.2019.12.005
Background The environment has an important role in the transmission of healthcare associated infections. This has encouraged interest in novel methods to improve hygiene in h...

Design of a New Peptide Substrate Probe of the Putative Biomarker Legumain with Potential Application in Prostate Cancer Diagnosis ex vivo

Journal Article
Mathur, S., Turnbull, A., Akaev, I., Stevens, C., Agrawal, N., Chopra, M., & Mincher, D. (in press)
Design of a New Peptide Substrate Probe of the Putative Biomarker Legumain with Potential Application in Prostate Cancer Diagnosis ex vivo. International Journal of Peptide Research and Therapeutics, https://doi.org/10.1007/s10989-019-09994-1
The lysosomal endoprotease legumain (asparaginyl endoprotease) has been proposed as a putative biomarker in prostate tumours, in which the enzyme is markedly overexpressed. Ov...

In situ characterization of nanoscale strains in loaded whole joints via synchrotron X-ray tomography

Journal Article
Madi, K., Staines, K., Bay, B., Javaheri, B., Geng, H., Bodey, A., …Lee, P. (2020)
In situ characterization of nanoscale strains in loaded whole joints via synchrotron X-ray tomography. Nature Biomedical Engineering, 4(3), 343-354. https://doi.org/10.1038/s41551-019-0477-1
Imaging techniques for quantifying changes in the hierarchical structure of deforming joints are constrained by destructive sample treatments, sample-size restrictions and len...

Raman spectroscopy links differentiating osteoblast matrix signatures to pro-angiogenic potential

Journal Article
Sharma, A., Goring, A., Staines, K., Emery, R., Pitsillides, A. A., Oreffo, R. O., …Clarkin, C. E. (2020)
Raman spectroscopy links differentiating osteoblast matrix signatures to pro-angiogenic potential. Matrix Biology Plus, 5(February 2020), https://doi.org/10.1016/j.mbplus.2019.100018
Mineralization of bone is achieved by the sequential maturation of the immature amorphous calcium phase to mature hydroxyapatite and is central to the process of bone developm...
27 results

Investigating the prevalence and diversity of bacterial endosymbionts in Scottish hoverfly populations

2020 - 2021
Investigating the prevalence and diversity of bacterial endosymbionts in Scottish hoverfly populations
Funder: Carnegie Trust for the Universities of Scotland | Value: £13,549

Prevalence of Brucellosis and Q-fever in livestock within the Ashanti region of Ghana

2020 - 2021
To determine the seroprevalence of abortifacient zoonoses (Brucellosis and Coxiellosis) in small ruminants within the Ashanti region of Ghana
Funder: Microbiology Society | Value: £2,530

Host Defence Peptides as novel modulators of autophagy in Inflammatory Bowel Disease

2019 - 2022
Increasing numbers of patients are diagnosed with inflammatory bowel disease (IBD) each year, both in the United Kingdom and worldwide. Most drugs in current use for the treatment of IBD target the im...
Funder: The Daphne Jackson Trust | Value: £83,167

EEID travel award: Understanding transmission dynamics for bacterial zoonoses in humans, goats and camels among pastoral communities in Northern Kenya

2019 - 2019
EEID travel award: Understanding transmission dynamics for bacterial zoonoses in humans, goats and camels among pastoral communities in Northern Kenya
Funder: Biotechnology and Biological Sciences Research Council | Value: £1,960

Can exposure to excess androgen during fetal life increase risk of hepatic disease in male offspring?

2019 - 2019
Background Polycystic ovary syndrome (PCOS) is a common condition. Hyperandrogenaemia characterises PCOS, and is considered an ‘in utero environmental programmer’ of PCOS in female offspring. Male o...
Funder: Society for Reproduction and Fertility | Value: £3,000

Cathelicidins as Novel Therapeutic Antivirals for Dengue Infection

2019 - 2022
A significant challenge faced by modern society is the lack of therapeutics for a large number of infections, particularly those that are endemic or widely spread in developing countries. Dengue is on...
Funder: Medical Research Council | Value: £269,873

Bacteriophage endolysins and novel lipid-degrading proteins as a treatment for Rhodococcus equi infections in foals

2018 - 2019
Rhodococcus equi (Req) is responsible for severe respiratory disease of foals with a major economic impact on the equine industry, and can be endemic on stud farms. In foals under 6 months of age, thi...
Funder: Horserace Betting Levy Board | Value: £10,832

Osteoarthritis: Going back to basics

2018 - 2021
Osteoarthritis (OA) is the most important ageing-related musculoskeletal disease, affecting almost 9 million people in the UK. Despite this, there remain many unanswered questions in our understanding...
Funder: Medical Research Council | Value: £351,321

Rutherford fund Strategic Partner Grant

2018 - 2019
Rutherford Fellows, will work in project areas related to food safety (Pathogen detection, AMR etc) and food spoilage. Rutherford Fund, are funded by BEIS and the scheme is being managed by Universit...
Funder: Department for Business, Energy & Industrial Strategy | Value: £39,800

Development of a novel 3D culture system to understand bone:cartilage crosstalk in osteoarthritis

2018 - 2022
Osteoarthritis affects more than 9 million people in the UK and is the leading cause of disability. In osteoarthritis, joint tissues (cartilage and bone) undergo structural damage which ultimately pro...
Funder: Medical Research Scotland | Value: £128,430