Research Output
Chromosomal localization of GABAA receptor subunit genes: relationship to human genetic disease
  Hybridization of {GABAA} receptor probes to human chromosomes in situ and to {DNA} from sorted human chromosomes has localized the genes encoding a β subunit and three isoforms of the a subunit. The α2 and β genes are both located on chromosome 4 in bands p12–p13 and may be adjacent. The α1 gene is on chromosome 5 (bands q34–q35) and the α3 gene is on the X chromosome. The a3 locus was mapped also on the mouse X chromosome using genetic break-point analysis in an interspecies pedigree. The combined results locate the human a3 gene within band Xg28, in a location that makes it a candidate gene for the X-linked form of manic depression.

  • Type:

    Article

  • Date:

    30 November 1989

  • Publication Status:

    Published

  • DOI:

    10.1016/0896-6273(89)90275-4

  • Cross Ref:

    0896627389902754

  • ISSN:

    0896-6273

  • Library of Congress:

    QD415-436 Biochemistry

  • Dewey Decimal Classification:

    572 Biochemistry

Citation

Buckle, V. J., Fujita, N., Ryder-Cook, A. S., Derry, J. M., Barnard, P. J., Lebo, R. V., …Barnard, E. A. (1989). Chromosomal localization of GABAA receptor subunit genes: relationship to human genetic disease. Neuron, 3(5), 647-654. https://doi.org/10.1016/0896-6273%2889%2990275-4

Keywords

General Neuroscience

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