Research Output
Generation of “Neoheparin” from E. coli K5 Capsular Polysaccharide
  Heparin remains a major drug in prevention of thromboembolic disease. Concerns related to its animal source have prompted search for heparin analogues. The anticoagulant activity of heparin depends on a specific pentasaccharide sequence that binds antithrombin. We report the generation of a product with antithrombin-binding, anticoagulant, and antithrombotic properties similar to those of heparin, through combined chemical and enzymatic modification of a bacterial (E. coli K5) polysaccharide. The process is readily applicable to large-scale production.

  • Type:

    Article

  • Date:

    31 December 2004

  • Publication Status:

    Published

  • DOI:

    10.1021/jm049812m

  • Cross Ref:

    10.1021/jm049812m

  • ISSN:

    0022-2623

  • Library of Congress:

    QD Chemistry

  • Dewey Decimal Classification:

    540 Chemistry

Citation

Lindahl, U., Li, J., Kusche-Gullberg, M., Salmivirta, M., Alaranta, S., Veromaa, T., …Casu, B. (2005). Generation of “Neoheparin” from E. coli K5 Capsular Polysaccharide. Journal of Medicinal Chemistry, 48(2), 349-352. https://doi.org/10.1021/jm049812m

Authors

Keywords

Thromboembolic disease, heparin

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