Research Output
Molecular cloning reveals the existence of a fourth γ subunit of the vertebrate brain GABAAreceptor
  We have isolated a cDNA, from the chicken, that encodes a fourth type of γ subunit of the vertebrate brain GABAA receptor. The mature polypeptide (which we name γ4) displays 67%, 69% and 70% identity, respectively, to the rat γ1, γ2 and γ3 subunits. In the developing chicken brain, the γ4‐subunit mRNA is first detected at embryonic day 13; the transcript level then increases progressively during embryogenesis. In situ hybridization reveals that the γ4‐subunit mRNA is abundant in several brain regions, including the ectostriatum, nucleus rotundus and hyperstriatum ventrale, which are involved in visual processing and learning.

  • Type:

    Article

  • Date:

    04 October 1993

  • Publication Status:

    Published

  • Publisher

    Wiley-Blackwell

  • DOI:

    10.1016/0014-5793(93)80339-v

  • ISSN:

    0014-5793

  • Library of Congress:

    QH426 Genetics

  • Dewey Decimal Classification:

    576 Genetics & evolution

Citation

Harvey, R. J., Kim, H., & Darlison, M. G. (1993). Molecular cloning reveals the existence of a fourth γ subunit of the vertebrate brain GABAAreceptor. FEBS Letters, 331(3), 211-216. https://doi.org/10.1016/0014-5793%2893%2980339-v

Keywords

Biophysics; Genetics; Cell Biology; Biochemistry; Molecular Biology; Structural Biology

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