Research Output

Oral streptogramins in the management of patients with methicillin-resistant Staphylococcus aureus (MRSA) infections.

  Objectives: Chronic methicillin-resistant Staphylococcus aureus (MRSA) infections in debilitated patients are difficult to treat. We studied the clinical efficacy and safety of an oral streptogramin, pristinamycin, for these patients.

Patients and methods: Patients were admitted consecutively to receive pristinamycin, usually with doxycycline, for 7–21 days. Fifty-six patients (average age 75 years) from hospital and community were treated for skin, soft tissue, chest and other infections.

Results: The overall clinical response rate was 39 of 53 patients (74%; 95% CI: 60%, 85%) cured or substantially improved, from 53 of 56 (95%) patients clinically and 49 of 56 (87.5%) patients bacteriologically evaluable. Toxic effects comprised gastrointestinal disturbances in eight patients (14%) and one (2%) possible skin rash.

Conclusion: This study suggests that oral streptogramins may be useful in the management of debilitated patients with MRSA infections

  • Type:

    Article

  • Date:

    30 November 2002

  • Publication Status:

    Published

  • Publisher

    Oxford University Press

  • DOI:

    10.1093/jac/dkg143

  • ISSN:

    1460-2091

  • Library of Congress:

    QR Microbiology

  • Dewey Decimal Classification:

    579 Microorganisms, fungi & algae

Citation

Dancer, S. J., Robb, A., Crawford, A. & Morrison, D. (2002). Oral streptogramins in the management of patients with methicillin-resistant Staphylococcus aureus (MRSA) infections. Journal of antimicrobial chemotherapy. 51, 731-735. doi:10.1093/jac/dkg143. ISSN 1460-2091

Authors

Keywords

Oral streptogramins; MRSA infections;

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