Research Output
The emerging role of E2F-1 in the DNA damage response and checkpoint control.
  Genotoxic stress triggers a myriad of cellular responses including cell cycle arrest, stimulation of {DNA} repair and apoptosis. A central role for the E2F-1 transcription factor in the {DNA} damage response pathway is gaining support. E2F-1 is phosphorylated by {DNA} damage responsive protein kinases, which leads to E2F-1 accumulation and the induction of apoptosis. In addition, emerging information suggests that E2F-1 may play a role in the detection and subsequent repair of damaged DNA.

  • Type:

    Article

  • Date:

    22 April 2004

  • Publication Status:

    Published

  • DOI:

    10.1016/j.dnarep.2004.03.034

  • Cross Ref:

    S1568786404001065

  • ISSN:

    1568-7864

  • Library of Congress:

    QD415-436 Biochemistry

  • Dewey Decimal Classification:

    572 Biochemistry

Citation

Stevens, C., & La Thangue, N. B. (2004). The emerging role of E2F-1 in the DNA damage response and checkpoint control. DNA Repair, 3(8-9), 1071-1079. https://doi.org/10.1016/j.dnarep.2004.03.034

Authors

Keywords

E2F-1DNA, repair, DNA damage,

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