Research Output
The importance of the SIBLING family of proteins on skeletal mineralisation and bone remodelling
  The small integrin-binding ligand N-linked glycoprotein (SIBLING) family consists of osteopontin, bone sialoprotein, dentin matrix protein 1, dentin sialophosphoprotein and matrix extracellular phosphoglycoprotein. These proteins share many structural characteristics and are primarily located in bone and dentin. Accumulating evidence has implicated the SIBLING proteins in matrix mineralisation. Therefore, in this review, we discuss the individual role that each of the SIBLING proteins has in this highly orchestrated process. In particular, we emphasise how the nature and extent of their proteolytic processing and post-translational modification affect their functional role. Finally, we describe the likely roles of the SIBLING proteins in clinical disorders of hypophosphataemia and their potential therapeutic use.

  • Type:

    Article

  • Date:

    13 June 2012

  • Publication Status:

    Published

  • Publisher

    BioScientifica

  • DOI:

    10.1530/joe-12-0143

  • ISSN:

    0022-0795

  • Library of Congress:

    RM Therapeutics. Pharmacology

  • Dewey Decimal Classification:

    615 Pharmacology and therapeutics

Citation

Staines, K. A., MacRae, V. E., & Farquharson, C. (2012). The importance of the SIBLING family of proteins on skeletal mineralisation and bone remodelling. Journal of Endocrinology, 214(3), 241-255. https://doi.org/10.1530/joe-12-0143

Authors

Keywords

Bone, SIBLING proteins, proteolytic processing, hypophosphataemia,

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