Research Output

Tracking Staphylococcus aureus in ICU using Whole-Genome Sequencing

  Background
Staphylococcus aureus remains an important bacterial pathogen worldwide. This study utilized known staphylococcal epidemiology to track S. aureus between different ecological reservoirs in one ten-bed intensive care unit (ICU).

Methods
Selected hand-touch surfaces, staff hands and air were systematically screened ten times during ten months, with patients screened throughout the study. S. aureus isolates were subjected to spa typing and epidemiological analyses, followed by whole-genome sequencing (WGS) to provide single nucleotide polymorphism (SNP) data.

Results
Multiple transmission pathways between patients and reservoirs were investigated. There were 34 transmission events, of which 29 were highly related (

  • Type:

    Article

  • Date:

    27 April 2019

  • Publication Status:

    In Press

  • Publisher

    Elsevier BV

  • DOI:

    10.1016/j.jhin.2019.04.016

  • Cross Ref:

    S0195670119301859

  • ISSN:

    0195-6701

  • Library of Congress:

    QR Microbiology

  • Dewey Decimal Classification:

    616 Diseases

  • Funders:

    NHS Health Scotland

Citation

Dancer, S. J., Adams, C. E., Smith, J., Pichon, B., Kearns, A., & Morrison, D. (in press). Tracking Staphylococcus aureus in ICU using Whole-Genome Sequencing. Journal of Hospital Infection, https://doi.org/10.1016/j.jhin.2019.04.016

Authors

Keywords

Microbiology (medical); Infectious Diseases; General Medicine

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