Edinburgh Napier University

  Pain experience is a notoriously difficult construct to measure as it is inherently subjective and personal, yet some sort of metric is required to monitor symptoms and treatments and is the necessary primary endpoint for clinical trials of interventions to reduce pain. In knee osteoarthritis, pain scores often don’t associate with joint deterioration and there is no gold standard by which to evaluate symptoms. This study is a proof of concept evaluation of the ability to measure physiological parameters associated with nociception and link to movement parameters to a known pain stimulus within a controlled gait laboratory setting.