Lecturer and Research Leader in Biomedical Sciences
Ross, M., Tormey, P., Ingram, L., Simpson, R., Malone, E., & Florida-James, G. (2016). A 10 km time trial running bout acutely increases the number of angiogenic T cells in the peripheral blood compartment of healthy males: Acute exercise mobilizes angiogenic T cells. Experimental Physiology, 101(10), (1253-1264). doi:10.1113/ep085771. ISSN 0958-0670
What is the central question of the study?
Are CD31+ angiogenic T (TANG) cells preferentially mobilized in response to acute exercise?
What is the main finding an...
Hubbard, G., O’Carroll, R., Munro, J., Mutrie, N., Haw, S., Mason, H., & Treweek, S. (2016). The feasibility and acceptability of trial procedures for a pragmatic randomised controlled trial of a structured physical activity intervention for people diagnosed with colorectal cancer: findings from a pilot trial of cardiac rehabilitation versus usual care (no rehabilitation) with an embedded qualitative study. Pilot and Feasibility Studies, 2(1), doi:10.1186/s40814-016-0090-y. ISSN 2055-5784
Background: Pilot and feasibility work is conducted to evaluate the operational feasibility and acceptability of the intervention itself and the feasibility and acceptability ...
Simpson, R. J., Cosgrove, C., Ingram, L. A., Florida-James, G. D., Whyte, G. P., Pircher, H. & Guy, K. (2008). Senescent T-lymphocytes are mobilised into the peripheral blood compartment in young and older humans after exhaustive exercise. Brain, Behavior, and Immunity. 22(4), 544-551. doi:10.1016/j.bbi.2007.11.002. ISSN 0889-1591
Senescent T-lymphocytes are antigen-experienced cells that express the killer-cell lectin-like receptor G1 (KLRG1) and/or CD57; fail to clonally expand following further antig...
Chief Scientists Office
We have identified the human cathelicidn LL-37 as having potent direct antiviral activity against human rhinovirus (HRV), together with the capacity to alter death pathways in HRV-infected cells, as a...
Scottish Funding Council
Development of a UV-C hand-sanitiser unit
Crohn's in Childhood Research Association
An investigation of commonly used IBD drugs on autophagy pathway activity and potential therapeutic benefit for treatment of paediatric IBD
20 April 2017
21 April 2017
The Biological Visualisation Community's 3rd Annual Meeting takes place at Craiglockhart Campus in Edinburgh on 20th-21st April 2017.
This two day meeting compri...
Senior Research Fellow
Associate Professor of Immunology & Infection / Director of Research, School of Applied Sciences
Lin, Y., Stevens, C. & Hupp, T. (2007). Identification of a Dominant Negative Functional Domain on DAPK-1 That Degrades DAPK-1 Protein and Stimulates TNFR-1-mediated Apoptosis. Journal of Biological Chemistry. 282, 16792-16802. doi:10.1074/jbc.M611559200. ISSN 0021-9258
DAPK-1 is a stress-activated tumor suppressor protein that plays a role in both proapoptotic or antiapoptotic signal transduction pathways. To define mechanisms of DAPK-1 prot...
Stevens, C., Lin, Y., Sanchez, M., Amin, E., Copson, E., White, H., …Hupp, T. (2007). A Germ Line Mutation in the Death Domain of DAPK-1 Inactivates ERK-induced Apoptosis. Journal of Biological Chemistry. 282, 13791-13803. doi:10.1074/jbc.M605649200. ISSN 0021-9258
p53 is activated genetically by a set of kinases that are components of the calcium calmodulin kinase superfamily, including CHK2, AMP kinase, and DAPK-1. In dissecting the me...
Taylor, C. M., Goldrick, M., Lord, L. & Roberts, I. S. (2005). Mutations in the waaR Gene of Escherichia coli Which Disrupt Lipopolysaccharide Outer Core Biosynthesis Affect Cell Surface Retention of Group 2 Capsular Polysaccharides. Journal of Bacteriology. 188(3), 1165-1168. doi:10.1128/JB.188.3.1165-1168.2006. ISSN 0021-9193
On the basis of increased resistance to K5 capsule-specific bacteriophage, a waaR transposon mutant defective in the biosynthesis of lipopolysaccharide outer core was isolated...
Roberts, I., & Taylor, C. (2005). Bacterial Capsules: A Route for Polysaccharide Engineering. In Handbook of Carbohydrate Engineering, 479-494. Boca Raton, USA: CRC Press (Taylor and Francis Group). doi:10.1201/9781420027631.ch16
No abstract available.
Simpson, R. J., Guy, K., Whyte, G. P., & Florida-James, G. D. (2005). Lymphocyte Apoptosis, Adhesion/activation Molecules And Complement Regulatory Proteins Following Intensive, Moderate And Eccentric Exercise: 1739 11:30 AM ??? 11:45 AM. Medicine and science in sports and exercise, 37(Supplement), (S336). doi:10.1097/00005768-200505001-01738. ISSN 0195-9131
Mitchell, B. G., Farrington, A., Allen, M., Gardner, A., Hall, L., Barnett, A. G., …Graves, N. (2017). Variation in hospital cleaning practice and process in Australian hospitals: A structured mapping exercise. Infection, Disease & Health. doi:10.1016/j.idh.2017.08.001. ISSN 2468-0451
The purpose of this paper is to highlight the range of cleaning practices and processes in 11 Australian hospitals and to discuss the challenges this variation pose...
Wojcik, G., Kydonaki, C., Willis, D. & Williams, B. (2017, March). An integrative review of factors influencing the use of antibiotic de-escalation in hospital setting. Poster presented at Edinburgh Antimicrobial Resistance Research Symposium, Edinburgh
Coyle, C. (2014). The Roles and Expression of Cationic Host Defence Peptides in Normal and Compromised Pregnancies. (Thesis)
Cationic Host Defense Peptides (CHDP), also known as antimicrobial peptides, are key components of the host innate immune response that have a wide range of direct microbicida...
British Association of Sport and Exercise Sciences
The project will measure circulating white blood cells and progenitor cells in response to an extreme exercise running bout/event/ We will also be quantifying upper respiratory tract symptoms.
Consejo Superior de Investigaciones Científicas
The main goal of this project is to understand the mechanisms responsible for the virulence of food-related yeasts on humans, and to provide tools and recommendations to prevent the release of yeasts ...