Research explorer tool

Date


Themes

Download Available

40 results

Key actions for a sustainable chemicals policy

Journal Article
Collins, C., Depledge, M., Fraser, R., Johnson, A., Hutchison, G., Matthiessen, P., …Sumpter, J. (2020)
Key actions for a sustainable chemicals policy. Environment International, 137, https://doi.org/10.1016/j.envint.2020.105463
Chemicals policies have spawned a wide range of regulations aimed at limiting damage to the environment and human health. Most instruments are reactive and fragmented. We prop...

Editorial

Journal Article
Hutchison, G. (2018)
Editorial. Ology: Reviews in Applied Sciences, 1, 3. https://doi.org/10.14297/ras.v1i1.5
No abstract available.

Silver nanoparticles promote the emergence of heterogeneic human neutrophil sub-populations

Journal Article
Kemp, S., Young, L., Ross, M., Prach, M., Hutchison, G. R., Malone, E., & Fraser, J. A. (2018)
Silver nanoparticles promote the emergence of heterogeneic human neutrophil sub-populations. Scientific Reports, 8(1), https://doi.org/10.1038/s41598-018-25854-2
Neutrophil surveillance is central to nanoparticle clearance. Silver nanoparticles (AgNP) have numerous uses, however conflicting evidence exists as to their impact on neutrop...

Investigating the molecular mechanisms driving neuroendocrine differentiation in androgen deprived prostate cancer cells

Conference Proceeding
Sutton, J., Hutchison, G., Fraser, J., & Poole, A. (2016)
Investigating the molecular mechanisms driving neuroendocrine differentiation in androgen deprived prostate cancer cells
Background: Neuroendocrine differentiation is commonplace in prostate tumors treated with androgen deprivation therapy and is associated with castrate-resistant disease progre...

Development of in vitro strategies to predict in vivo toxicity of engineered nanoparticles to the male reproductive system.

Presentation / Conference
Malone, E., Ross, B., Rae, M., Bouwmeester, H., Gosens, I., Cassee, F., …Hutchison, G. (2016, September)
Development of in vitro strategies to predict in vivo toxicity of engineered nanoparticles to the male reproductive system. Poster presented at 11th International Particle Toxicology Conference, Singapore
The introduction of engineered nanomaterials (ENM) to new materials and products requires informed risk assessment. The altered physico-chemical properties of ENM mean traditi...

A perspective on the developmental toxicity of inhaled nanoparticles.

Journal Article
Hougaard, K. S., Campagnolo, L., Chavatte-Palmer, P., Tarrade, A., Rousseau-Ralliard, D., Valentino, S., …Cassee, F. R. (2015)
A perspective on the developmental toxicity of inhaled nanoparticles. Reproductive Toxicology, 56, 118-140. https://doi.org/10.1016/j.reprotox.2015.05.015
This paper aimed to clarify whether maternal inhalation of engineered nanoparticles (NP) may constitute a hazard to pregnancy and fetal development, primarily based on experim...

Comprehensive In Vitro Toxicity Testing of a Panel of Representative Oxide Nanomaterials: First Steps towards an Intelligent Testing Strategy

Journal Article
Zhu, D., Farcal, L., Torres Andón, F., Di Cristo, L., Rotoli, B. M., Bussolati, O., …Fadeel, B. (2015)
Comprehensive In Vitro Toxicity Testing of a Panel of Representative Oxide Nanomaterials: First Steps towards an Intelligent Testing Strategy. PLOS ONE, 10, https://doi.org/10.1371/journal.pone.0127174
Nanomaterials (NMs) display many unique and useful physico-chemical properties. However, reliable approaches are needed for risk assessment of NMs. The present study was perfo...

Comparative Effects of Di(n-Butyl) Phthalate Exposure on Fetal Germ Cell Development in the Rat and in Human Fetal Testis Xenografts

Journal Article
van den Driesche, S., McKinnell, C., Calarrão, A., Kennedy, L., Hutchison, G. R., Hrabalkova, L., …Mitchell, R. T. (2015)
Comparative Effects of Di(n-Butyl) Phthalate Exposure on Fetal Germ Cell Development in the Rat and in Human Fetal Testis Xenografts. Environmental Health Perspectives, 123(3), 223-230. https://doi.org/10.1289/ehp.1408248
Background: Phthalate exposure induces germ cell effects in the fetal rat testis. Although experimental models have shown that the human fetal testis is insensitive to the ste...

Reproductive toxicity of nanomaterials.

Book Chapter
Saunders, M., Hutchison, G., & Carreira, S. C. (2014)
Reproductive toxicity of nanomaterials. In B. Fadeel (Ed.), Handbook of Safety Assessment of Nanomaterials: From toxicological Testing to Personalised medicine, 461-481. CRC Press (Taylor and Francis Group
No abstract available.

Imaging of activated complement using ultrasmall superparamagnetic iron oxide particles (USPIO) - conjugated vectors: an in vivo in utero non-invasive method to predict placental insufficiency and abnormal fetal brain development.

Journal Article
Girardi, G., Fraser, J. A., Lennen, R., Vontell, R., Jansen, M., & Hutchison, G. (2015)
Imaging of activated complement using ultrasmall superparamagnetic iron oxide particles (USPIO) - conjugated vectors: an in vivo in utero non-invasive method to predict placental insufficiency and abnormal fetal brain development. Molecular Psychiatry, 20, 1017-1026. https://doi.org/10.1038/mp.2014.110
In the current study, we have developed a magnetic resonance imaging-based method for non-invasive detection of complement activation in placenta and foetal brain in vivo in u...

Date


Research Centres Groups

Research Areas

Themes

7 results

Bio-Nanomaterial Hazard Assessment: development of in vitro models to aid assessment of reproductive function in response to nanomedicines

2019 - date
Sarah Horgan | Director of Studies: Prof Gary Hutchison | Second Supervisor: Dr Eva Malone

Molecular mechanisms driving prostate cancer neuroendocrine differentiation

2014 - 2019
Prostate cancer is the second most common cancer amongst males and 10,000 deaths per year are attributed to the disease in th...
Joe Sutton | Director of Studies: Dr Amy Poole | Second Supervisor: Dr Jenny Fraser

The impact of nanomaterials on human host defence

2011 - 2016
Fern Findlay | Director of Studies: Prof Peter Barlow | Second Supervisor: Dr Lorna Proudfoot

In vitro investigation into invasion of Caco-2 cells by S. Typhimurium in response to nanoparticles and inhibition of EGFR

2011 - 2013
Anuj Sehgal | Director of Studies: Douglas Fraser-pitt | Second Supervisor: Dr dupe Pamela Cameron

Caenorhabditis elegans as a model for the assessment of nanomaterial toxicity

2011 - 2013
Louise Nicol | Director of Studies: Dr Lorna Proudfoot | Second Supervisor: Dr Eva Malone

Assessing toxicity of engineered nanomaterials in the male reproductive system: Developing an improved testing strategy for hazard assessment

2011 - 2019
"There is a paucity of knowledge relating to the effects of...
Bryony Ross | Director of Studies: Prof Gary Hutchison | Second Supervisor: Dr Eva Malone

The Toxicological Effects of PM10 Components On Lung Cells

2001 - 2004
Prof Gary Hutchison

Date


Date