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Carbon Nanoparticles Inhibit the Antimicrobial Activities of the Human Cathelicidin LL-37 through Structural Alteration

Journal Article
Findlay, F., Pohl, J., Svoboda, P., Shakamuri, P., McLean, K., Inglis, N. F., …Barlow, P. G. (2017)
Carbon Nanoparticles Inhibit the Antimicrobial Activities of the Human Cathelicidin LL-37 through Structural Alteration. Journal of Immunology, 199(7), 2483-2490. https://doi.org/10.4049/jimmunol.1700706
Host defense peptides, also known as antimicrobial peptides, are key elements of innate host defense. One host defense peptide with well-characterized antimicrobial activity i...

Cathelicidins display conserved direct antiviral activity towards rhinovirus.

Journal Article
Sousa, F. H., Casanova, V., Findlay, F., Stevens, C., Svoboda, P., Pohl, J., …Barlow, P. G. (2017)
Cathelicidins display conserved direct antiviral activity towards rhinovirus. Peptides, 95, 76-83. https://doi.org/10.1016/j.peptides.2017.07.013
Human rhinoviruses (HRVs) are the most common cause of viral respiratory tract infections, and are associated with significant morbidity and mortality in immunocompromised ind...

Development of mitochondria- and protease-specific prodrugs in the potential treatment of parasitic helminth infections

Presentation / Conference
Oluwadare, E., Rehan, A., Ding, Y., Turnbull, A., Malone, E., Mincher, D., & Proudfoot, L. (2016, September)
Development of mitochondria- and protease-specific prodrugs in the potential treatment of parasitic helminth infections. Poster presented at Molecular & Cellular Biology of Helminth Parasites X, Hydra, Greece
Anthelmintic resistance and the shortage of new drugs represent an urgent need for the development of novel anti-parasite drugs with effective delivery to the target site. Red...

Cationic host defense peptides; novel antimicrobial therapeutics against Category A pathogens and emerging infections

Journal Article
Findlay, F., Proudfoot, L., Stevens, C., & Barlow, P. G. (2016)
Cationic host defense peptides; novel antimicrobial therapeutics against Category A pathogens and emerging infections. Pathogens and Global Health, 110(4-5), 137-147. https://doi.org/10.1080/20477724.2016.1195036
Cationic Host Defense Peptides (HDP, also known as antimicrobial peptides) are crucial components of the innate immune system and possess broad-spectrum antibacterial, antivir...

Multi-walled carbon nanotube induced frustrated phagocytosis, cytotoxicity and pro-inflammatory conditions in macrophages are length dependent and greater than that of asbestos

Journal Article
Boyles, M. S., Young, L., Brown, D. M., MacCalman, L., Cowie, H., Moisala, A., …Stone, V. (2015)
Multi-walled carbon nanotube induced frustrated phagocytosis, cytotoxicity and pro-inflammatory conditions in macrophages are length dependent and greater than that of asbestos. Toxicology in Vitro, 29(7), 1513-1528. https://doi.org/10.1016/j.tiv.2015.06.012
The potential toxicity of carbon nanotubes (CNTs) has been compared to pathogenic fibres such as asbestos. It is important to test this hypothesis to ascertain safe methods fo...

Zinc oxide nanoparticles and monocytes: Impact of size, charge and solubility on activation status

Journal Article
Prach, M., Stone, V., & Proudfoot, L. (2012)
Zinc oxide nanoparticles and monocytes: Impact of size, charge and solubility on activation status. Toxicology and Applied Pharmacology, 266(1), 19-26. https://doi.org/10.1016/j.taap.2012.10.020
Zinc oxide (ZnO) particle induced cytotoxicity was dependent on size, charge and solubility, factors which at sublethal concentrations may influence the activation of the huma...

Nanoparticles and Neutrophil Activation

Presentation / Conference
Dickson, C., Prach, M., Fraser, J., Ingram, L., Barlow, P., Hutchison, G., …Malone, E. (2012, February)
Nanoparticles and Neutrophil Activation. Presented at NanoImpactNet-QNANO conference - European Network on the Health and Environmental Impact of Nanomaterials, Dublin, Ireland
Neutrophils, the rapid responders of the innate immune system, are central to the initial immune responses of a host to foreign particles. Circulating in the blood, they are t...

The impact of different nanoparticle surface chemistry and size on uptake and toxicity in a murine macrophage cell line.

Journal Article
Clift, M. J. D., Rothen-Rutishauer, B., Brown, D. M., Duffin, R., Donaldson, K., Proudfoot, L., …Stone, V. (2008)
The impact of different nanoparticle surface chemistry and size on uptake and toxicity in a murine macrophage cell line. Toxicology and applied pharmacology, 232, 418-427. https://doi.org/10.1016/j.taap.2008.06.009
This study investigated the uptake, kinetics and cellular distribution of different surface coated quantum dots (QDs) before relating this to their toxicity. J774.A1 cells wer...

Effect of Nippostrongylus brasiliensis L3 ES on inflammatory mediator gene transcription in lipopolysaccharide lung inflammation

Journal Article
Zhao, M., Brown, D. M., MacCallum, J., & Proudfoot, L. (2008)
Effect of Nippostrongylus brasiliensis L3 ES on inflammatory mediator gene transcription in lipopolysaccharide lung inflammation. Parasite Immunology, 31(1), 50-56. https://doi.org/10.1111/j.1365-3024.2008.01073.x
The anti-inflammatory properties of parasitic helminths have been largely linked to their excretory-secretory (ES) products. Some studies have noted a lack of TNF-alpha produc...

Accute toxicity of linear alkylbenzene to Caenorhabditis elegans Maupas, 1900 in soil.

Journal Article
Johnson, S. J., Castan, M., Proudfoot, L., Barry, D. A. & Christofi, N. (2007)
Accute toxicity of linear alkylbenzene to Caenorhabditis elegans Maupas, 1900 in soil. Bulletin of Environmental Contamination and Toxicology. 79, 41-44. doi:10.1007/s00128-007-9195-6. ISSN 0007-4861
Linear alkybenzene (LAB) is a light non-aqueous phase liquid (LNAPL) whose primary use is as a precursor in the manufacture of linear alkylbenzene sulphonate (LAS) detergents....
12 results

Design, synthesis and biological evaluation of novel targeted anthelmintic agents

2015 - 2020
Aiman Rehan | Director of Studies: Dr David Mincher | Second Supervisor: Agnes Turnbull

The effects of Inflammatory Bowel Disease drugs on the autophagy pathway

2014 - 2019
Inflammatory Bowel Disease (IBD), which includes Crohn’s disease (CD) and Ulcerative Colitis, is characterised by chronic inflam...
Kirsty Hooper | Director of Studies: Dr Craig Stevens | Second Supervisor: Prof Peter Barlow

The role of the cytoskeleton in autophagy and Crohn's disease

2014 - 2020
Olga Biskou | Director of Studies: Dr Craig Stevens | Second Supervisor: Prof Peter Barlow

Regulation of autophagy in cathelicidin/vitamin D signalling pathway

2014 - 2016
Sophie Shepherd | Director of Studies: Dr Craig Stevens | Second Supervisor: Prof Peter Barlow

The development of a caenorhabtitis elegans model for the assessment of toxicity: application in the treatment of parasitic worm infections

2013 - 2017
Eyitayo Oluwadare | Director of Studies: Dr Lorna Proudfoot | Second Supervisor: Dr Eva Malone

Caenorhabditis elegans as a model for the assessment of nanomaterial toxicity

2011 - 2013
Louise Nicol | Director of Studies: Dr Lorna Proudfoot | Second Supervisor: Dr Eva Malone

The impact of nanomaterials on human host defence

2011 - 2016
Fern Findlay | Director of Studies: Prof Peter Barlow | Second Supervisor: Dr Lorna Proudfoot

The toxicity and potential pathogenicity of high-performance engineered multi-walled carbon nanotubes

2007 - 2012
Matthew Boyles | Director of Studies: Vicki Stone

Inhibition of lipopolysaccharide-induced lung inflamation by Nippostrongylus brasiliensis larvae and excretory-secretory products (ES)

2005 - 2009
Nippostrongylus brasiliensis is a rodent intestinal nematode with ...
Min Zhao | Director of Studies: Dr Lorna Proudfoot | Second Supervisor: Dr Janis MacCallum

Quantum Dots: An investigation into how differing surface characteristics affect their interaction with macrophages in vitro

2005 - 2008
Martin Clift | Director of Studies: Vicki Stone | Second Supervisor: Keith Guy

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