39 results

Increased linear bone growth by GH in the absence of SOCS2 is independent of IGF-1: SOCS2 REGULATION OF GH INDUCED GROWTH

Journal Article
Dobie, R., Ahmed, S. F., Staines, K. A., Pass, C., Jasim, S., MacRae, V. E., & Farquharson, C. (2015)
Increased linear bone growth by GH in the absence of SOCS2 is independent of IGF-1: SOCS2 REGULATION OF GH INDUCED GROWTH. Journal of Cellular Physiology, 230(11), 2796-2806. https://doi.org/10.1002/jcp.25006
Growth hormone (GH) signaling is essential for postnatal linear bone growth, but the relative importance of GHs actions on the liver and/or growth plate cartilage remains uncl...

miRNA-221 and miRNA-222 synergistically function to promote vascular calcification: MIR221/222 PROMOTE VASCULAR CALCIFICATION

Journal Article
Mackenzie, N. C. W., Staines, K. A., Zhu, D., Genever, P., & MacRae, V. E. (2014)
miRNA-221 and miRNA-222 synergistically function to promote vascular calcification: MIR221/222 PROMOTE VASCULAR CALCIFICATION. Cell Biochemistry and Function, 32(2), 209-216. https://doi.org/10.1002/cbf.3005
Vascular calcification shares many similarities with skeletal mineralisation and involves the phenotypic trans-differentiation of vascular smooth muscle cells (VSMCs) to osteo...

Cartilage to bone transitions in health and disease

Journal Article
Staines, K. A., Pollard, A. S., McGonnell, I. M., Farquharson, C., & Pitsillides, A. A. (2013)
Cartilage to bone transitions in health and disease. Journal of Endocrinology, 219(1), R1-R12. https://doi.org/10.1530/joe-13-0276
Aberrant redeployment of the 'transient' events responsible for bone development and postnatal longitudinal growth has been reported in some diseases in what is otherwise inhe...

Identification of novel regulators of osteoblast matrix mineralization by time series transcriptional profiling

Journal Article
Staines, K. A., Zhu, D., Farquharson, C., & MacRae, V. E. (2014)
Identification of novel regulators of osteoblast matrix mineralization by time series transcriptional profiling. Journal of Bone and Mineral Metabolism, 32(3), 240-251. https://doi.org/10.1007/s00774-013-0493-2
Bone mineralization is a carefully orchestrated process, regulated by a number of promoters and inhibitors that function to ensure effective hydroxyapatite formation. Here we ...

Chondrogenic ATDC5 cells: An optimised model for rapid and physiological matrix mineralisation

Journal Article
Newton, P. T., Staines, K. .. . A., Spevak, L., Boskey, A. L., Teixeira, C. C., Macrae, V. E., …Farquharson, C. (2012)
Chondrogenic ATDC5 cells: An optimised model for rapid and physiological matrix mineralisation. International Journal of Molecular Medicine, 30(5), 1187-1193. https://doi.org/10.3892/ijmm.2012.1114
The development of chondrogenic cell lines has led to major advances in the understanding of how chondrocyte differentiation is regulated, and has uncovered many signalling pa...

MEPE is a novel regulator of growth plate cartilage mineralization

Journal Article
Staines, K. A., Mackenzie, N. C. W., Clarkin, C. E., Zelenchuk, L., Rowe, P. S., MacRae, V. E., & Farquharson, C. (2012)
MEPE is a novel regulator of growth plate cartilage mineralization. Bone, 51(3), 418-430. https://doi.org/10.1016/j.bone.2012.06.022
Matrix extracellular phosphoglycoprotein (MEPE) belongs to the SIBLING protein family which play key roles in biomineralization. Although the growth plates of MEPE-overexpress...

Cartilage development and degeneration: a Wnt Wnt situation - cartilage development and degeneration: a WNT WNT situation

Journal Article
Staines, K. A., MacRae, V. E., & Farquharson, C. (2012)
Cartilage development and degeneration: a Wnt Wnt situation - cartilage development and degeneration: a WNT WNT situation. Cell Biochemistry and Function, 30(8), 633-642. https://doi.org/10.1002/cbf.2852
The Wnt signaling pathway plays a crucial role in the development and homeostasis of a variety of adult tissues and, as such, is emerging as an important therapeutic target fo...

The importance of the SIBLING family of proteins on skeletal mineralisation and bone remodelling

Journal Article
Staines, K. A., MacRae, V. E., & Farquharson, C. (2012)
The importance of the SIBLING family of proteins on skeletal mineralisation and bone remodelling. Journal of Endocrinology, 214(3), 241-255. https://doi.org/10.1530/joe-12-0143
The small integrin-binding ligand N-linked glycoprotein (SIBLING) family consists of osteopontin, bone sialoprotein, dentin matrix protein 1, dentin sialophosphoprotein and ma...

The skeleton: no bones about it

Journal Article
Farquharson, C., & Staines, K. (2011)
The skeleton: no bones about it. Journal of Endocrinology, 211(2), 107-108. doi:10.1530/joe-11-0274
NO abstract available.