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Life course longitudinal growth and risk of knee osteoarthritis at age 53 years: evidence from the 1946 British birth cohort study

Journal Article
Staines, K. A., Hardy, R., Samvelyan, H. J., Ward, K. A., & Cooper, R. (in press)
Life course longitudinal growth and risk of knee osteoarthritis at age 53 years: evidence from the 1946 British birth cohort study. Osteoarthritis and Cartilage, https://doi.org/10.1016/j.joca.2020.12.012
Objective To examine the relationship between height gain across childhood and adolescence with knee osteoarthritis in the MRC National Survey of Health and Development (NSHD)...

Zinc ameliorates human aortic valve calcification through GPR39 mediated ERK1/2 signalling pathway

Journal Article
Chen, Z., Gordillo-Martinez, F., Jiang, L., He, P., Hong, W., Wei, X., …Zhu, D. (in press)
Zinc ameliorates human aortic valve calcification through GPR39 mediated ERK1/2 signalling pathway. Cardiovascular Research, https://doi.org/10.1093/cvr/cvaa090
Aims Calcific aortic valve disease (CAVD) is the most common heart valve disease in the Western world. It has been reported that zinc is accumulated in calcified human aortic ...

Models of osteoarthritis: relevance and new insights

Journal Article
Samvelyan, H., Hughes, D., Stevens, C., & Staines, K. A. (in press)
Models of osteoarthritis: relevance and new insights. Calcified Tissue International, https://doi.org/10.1007/s00223-020-00670-x
Osteoarthritis (OA) is a progressive and disabling musculoskeletal disease affecting millions of people and resulting in major healthcare costs worldwide. It is the most commo...

Conditional deletion of E11/Podoplanin in bone protects against ovariectomy-induced increases in osteoclast formation and activity

Journal Article
Staines, K., Hopkinson, M., Dillon, S., Stephen, L., Fleming, R., Sophocleous, A., …Farquharson, C. (2020)
Conditional deletion of E11/Podoplanin in bone protects against ovariectomy-induced increases in osteoclast formation and activity. Bioscience Reports, 40(1), https://doi.org/10.1042/BSR20190329
E11/Podoplanin (Pdpn) is implicated in early osteocytogenesis and the formation of osteocyte dendrites. This dendritic network is critical for bone modeling/remodeling, throug...

Azathioprine Has a Deleterious Effect on the Bone Health of Mice with DSS-Induced Inflammatory Bowel Disease

Journal Article
Morgan, S., Hooper, K. M., Milne, E. M., Farquharson, C., Stevens, C., & Staines, K. A. (2019)
Azathioprine Has a Deleterious Effect on the Bone Health of Mice with DSS-Induced Inflammatory Bowel Disease. International Journal of Molecular Sciences, 20(23), https://doi.org/10.3390/ijms20236085
Patients with inflammatory bowel disease (IBD) often present poor bone health and are 40% more at risk of bone fracture. Studies have implicated autophagy in IBD pathology and...

In situ characterization of nanoscale strains in loaded whole joints via synchrotron X-ray tomography

Journal Article
Madi, K., Staines, K., Bay, B., Javaheri, B., Geng, H., Bodey, A., …Lee, P. (2020)
In situ characterization of nanoscale strains in loaded whole joints via synchrotron X-ray tomography. Nature Biomedical Engineering, 4(3), 343-354. https://doi.org/10.1038/s41551-019-0477-1
Imaging techniques for quantifying changes in the hierarchical structure of deforming joints are constrained by destructive sample treatments, sample-size restrictions and len...

Raman spectroscopy links differentiating osteoblast matrix signatures to pro-angiogenic potential

Journal Article
Sharma, A., Goring, A., Staines, K., Emery, R., Pitsillides, A. A., Oreffo, R. O., …Clarkin, C. E. (2020)
Raman spectroscopy links differentiating osteoblast matrix signatures to pro-angiogenic potential. Matrix Biology Plus, 5(February 2020), https://doi.org/10.1016/j.mbplus.2019.100018
Mineralization of bone is achieved by the sequential maturation of the immature amorphous calcium phase to mature hydroxyapatite and is central to the process of bone developm...

Conditional deletion of E11/podoplanin in bone protects against load-induced osteoarthritis

Journal Article
Staines, K., Ikpegbu, E., Törnqvist, A., Dillon, S., Javaheri, B., Amin, A. K., …Farquharson, C. (2019)
Conditional deletion of E11/podoplanin in bone protects against load-induced osteoarthritis. BMC Musculoskeletal Disorders, 20, https://doi.org/10.1186/s12891-019-2731-9
Background: Subchondral bone (SCB) thickening is one of the earliest detectable changes in osteoarthritic joints and is considered a potential trigger for subsequent articular...

How to build a bone: PHOSPHO1, biomineralization and beyond

Journal Article
Dillon, S., Staines, K. A., Millán, J. L., & Farquharson, C. (2019)
How to build a bone: PHOSPHO1, biomineralization and beyond. Journal of Bone and Mineral Research Plus, 3(7), https://doi.org/10.1002/jbm4.10202
Since its characterization two decades ago, the phosphatase PHOSPHO1 has been the subject of an increasing focus of research. This work has elucidated PHOSPHO1’s central role ...

The inflammatory bowel disease drug azathioprine induces autophagy via mTORC1 and the unfolded protein response sensor PERK

Journal Article
Hooper, K. M., Casanova, V., Kemp, S., Staines, K. A., Satsangi, J., Barlow, P. G., …Stevens, C. (2019)
The inflammatory bowel disease drug azathioprine induces autophagy via mTORC1 and the unfolded protein response sensor PERK. Inflammatory Bowel Diseases, 25(9), 1481-1496. https://doi.org/10.1093/ibd/izz039
Background Genetic studies have strongly linked autophagy to Crohn's disease (CD) and stimulating autophagy in CD patients may be therapeutically beneficial. The aim of this s...

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