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Efficacy of two Chlamydia abortus subcellular vaccines in a pregnant ewe challenge model for ovine enzootic abortion

Journal Article
Livingstone, M., Ranjan Wattegedera, S., Palarea-Albaladejo, J., Aitchison, K., Corbett, C., Sait, M., …Longbottom, D. (2021)
Efficacy of two Chlamydia abortus subcellular vaccines in a pregnant ewe challenge model for ovine enzootic abortion. Vaccines, 9(8), https://doi.org/10.3390/vaccines9080898
Chlamydia abortus, the aetiological agent of enzootic abortion of ewes, is a major cause of reproductive loss in small ruminants worldwide, accounting for significant economic...

A global multinational survey of cefotaxime-resistant coliforms in urban wastewater treatment plants

Journal Article
Marano, R. B., Fernandes, T., Manaia, C. M., Nunes, O., Morrison, D., Berendonk, T. U., …Cytryn, E. (2020)
A global multinational survey of cefotaxime-resistant coliforms in urban wastewater treatment plants. Environment International, 144, https://doi.org/10.1016/j.envint.2020.106035
The World Health Organization Global Action Plan recommends integrated surveillance programs as crucial strategies for monitoring antibiotic resistance. Although several natio...

Understanding the attitudes and acceptability of extra-genital Chlamydia testing in young women: evaluation of a feasibility study

Journal Article
Brown, S., Paterson, C., Dougall, N., Cameron, S., & Wheelhouse, N. (2019)
Understanding the attitudes and acceptability of extra-genital Chlamydia testing in young women: evaluation of a feasibility study. BMC Public Health, 19(1), https://doi.org/10.1186/s12889-019-7313-0
Background Chlamydia trachomatis (C. trachomatis) is the most common bacterial sexually transmitted infection in the UK. Recent studies suggest that in addition to the genital...

Immunological homeostasis at the ovine placenta may reflect the degree of maternal foetal interaction

Journal Article
Wattegedera, S. R., Doull, L. E., Goncheva, M. I., Wheelhouse, N., Watson, D. M., Pearce, J., …Entrican, G. (2019)
Immunological homeostasis at the ovine placenta may reflect the degree of maternal foetal interaction. Frontiers in Immunology, 9, https://doi.org/10.3389/fimmu.2018.03025
Successful mammalian pregnancies are a result of complex physiological, endocrinological and immunological processes that combine to create an environment where the mother is ...

Ferlavirus-related deaths in a collection of viperid snakes

Journal Article
Flach, E. J., Dagleish, M. P., Feltrer, Y., Gill, I. S., Marschang, R. E., Masters, N., …Wheelhouse, N. M. (2018)
Ferlavirus-related deaths in a collection of viperid snakes. Journal of Zoo and Wildlife Medicine, 49(4), 983-995. https://doi.org/10.1638/2017-0223.1
Between June and October 2013 26 snakes of six viperid species kept in two adjoining rooms died (n = 16) or were euthanized on medical (1) or welfare grounds (9). Two were fro...

Researching skills development: students as partners in this process

Journal Article
Campbell Casey, S., MacCallum, J., Robertson, L., & Strachan, L. (2018)
Researching skills development: students as partners in this process. New Directions in the Teaching of Physical Sciences, 13(1), https://doi.org/10.29311/ndtps.v0i13.2881
Many employers report that newly qualified graduates lack key skills necessary for success in the workplace. Although variable, many lack general ‘transferable’ or ‘soft’ skil...

Sources and survival of Listeria monocytogenes on fresh, leafy produce

Journal Article
on fresh, leafy produce. Journal of Applied Microbiology, 125(4), 930-942. https://doi.org/10.1111/jam.14025

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on fresh, leafy produce. Journal of Applied Microbiology, 125(4), 930-942. https://doi.org/10.1111/jam.14025
Listeria monocytogenes in an intracellular human pathogen which enters the body through contaminated food stuffs and is known to contaminate fresh leafy produce such as spinac...

Sources and contamination routes of microbial pathogens to fresh produce during field cultivation: A review

Journal Article
Alegbeleye, O. O., Singleton, I., & Sant’Ana, A. S. (2018)
Sources and contamination routes of microbial pathogens to fresh produce during field cultivation: A review. Food Microbiology, 73, 177-208. https://doi.org/10.1016/j.fm.2018.01.003
Foodborne illness resulting from the consumption of contaminated fresh produce is a common phenomenon and has severe effects on human health together with severe economic and ...

Control of Antimicrobial Resistance Requires an Ethical Approach

Journal Article
Parsonage, B., Hagglund, P. K., Keogh, L., Wheelhouse, N., Brown, R. E., & Dancer, S. J. (2017)
Control of Antimicrobial Resistance Requires an Ethical Approach. Frontiers in Microbiology, 8, https://doi.org/10.3389/fmicb.2017.02124
Ethical behavior encompasses actions that benefit both self and society. This means that tackling antimicrobial resistance (AMR) becomes an ethical obligation, because the pro...

Pathogenic outcome following experimental infection of sheep with Chlamydia abortus variant strains LLG and POS

Journal Article
Livingstone, M., Wheelhouse, N., Ensor, H., Rocchi, M., Maley, S., Aitchison, K., …Longbottom, D. (2017)
Pathogenic outcome following experimental infection of sheep with Chlamydia abortus variant strains LLG and POS. PLOS ONE, 12(5), https://doi.org/10.1371/journal.pone.0177653
This study investigated the pathogenesis of two variant strains (LLG and POS) of Chlamydia abortus, in comparison to a typical wild-type strain (S26/3) which is known to be re...
27 results

Virulence of diverse Listeria monocytogenes strains in an invertebrate infection model

2022 - 2022
Listeria monocytogenes (L. monocytogenes) is a bacterium which is found throughout the environment and is the cause of listeriosis, a major food-borne disease. While annual case numbers are relatively...
Funder: Medical Research Scotland | Value: £2,160

Quantifying AMR in the River Almond Catchment Area

2021 - 2025
Aim To Quantifying AMR Pollution and identify the major sources of point and diffuse AMR pollution in the River Almond Catchment Area in order to provide a baseline for future risk assessment and inte...
Funder: Natural Environment Research Council | Value: £52,080

Scotland-India Antimicrobial Resistance in the Environment Network (SIAMREN)

2020 - 2021
This project focuses upon the creation and growth of a network of researchers within Scotland and India who have common research interests in the challenges presented by the emergence of antimicrobial...
Funder: Royal Society of Edinburgh

The prevalence of antibiotic resistance pathogen E. coli in Scottish surface waters

2019 - 2023
The alarming rise in resistance to antibiotics is now widely accepted as being one of the most serious public health crises we face today. The use and overuse of antibiotics in human and animal medici...
Funder: Medical Research Scotland | Value: £129,161

The role of NamA in L. monocytogenes virulence gene expression

2019 - 2020
Student Placement Scholarship 2019. Provides up to 8 weeks of paid laboratory experience for an undergraduate student.
Funder: Society of Applied Microbiology | Value: £2,500

Part 2 Novel insights, tools and measures to mitigate emerging risks by yeasts in the food chain II

2018 - 2020
This project is to understand the mechanisms responsible for the virulence of food-related yeasts on humans, and to provide tools and recommendations to prevent the release of yeast strains that pose ...
Funder: Consejo Superior de Investigaciones Científicas | Value: £6,390

Bacteriophage endolysins and novel lipid-degrading proteins as a treatment for Rhodococcus equi infections in foals

2018 - 2019
Rhodococcus equi (Req) is responsible for severe respiratory disease of foals with a major economic impact on the equine industry, and can be endemic on stud farms. In foals under 6 months of age, thi...
Funder: Horserace Betting Levy Board | Value: £10,832

Food security for vulnerable populations: the fungal threat

2018 - 2018
This workshop proposal is to challenge and invigorate career-development of the next generation of UK and Brazil scientists, through a unified focus on combatting the fungal threat to global food secu...
Funder: British Council

Rutherford fund Strategic Partner Grant

2018 - 2019
Rutherford Fellows, will work in project areas related to food safety (Pathogen detection, AMR etc) and food spoilage. Rutherford Fund, are funded by BEIS and the scheme is being managed by Universit...
Funder: Department for Business, Energy & Industrial Strategy | Value: £39,800

Direct and paracrine effects of Chlamydia infection on decidualisation of endometrial stromal cells

2018 - 2018
SRF summer studentship
Funder: Society for Reproduction and Fertility | Value: £2,750