Vice Chancellor's Research Fellow
Baudel, M., Rae, M., Fraser, J. & Poole, A. (2017). The expression of the chloride co-transporters NKCC1 and KCC2 is reversed in the penumbra following. In Brain and Neuroscience: BNA 2017 Festival of Neuroscience: Abstract BookISBN n/a
Stroke is one of the major causes of death and disability worldwide. The harm caused by the interruption of blood flow to the brain
unfolds in the subsequent hours and days, s...
Garden, C. & McLatchie, J. (2012). What Does My Turnitin Report Mean?
In this podcast Dr Claire Garden and Joan McLatchie discuss their use of Turnitin, an online text matching service. There are still many misconceptions about plagiarism detect...
Wilson, M. R., Barlow, P. G., Hutchison, G. R., Guy, K., Griffiths, A., Simpson, R. J., …Stone, V. (2004). Nanoparticle and metal interactions and their impact on lung toxicology. In Proceedings of the Ninth Annual UK Review Meeting on Outdoor and Indoor Air Pollution Research, 48-50. ISBN 1 899110 88 7
No abstract available.
Chief Scientists Office
We have identified the human cathelicidn LL-37 as having potent direct antiviral activity against human rhinovirus (HRV), together with the capacity to alter death pathways in HRV-infected cells, as a...
Crohn's in Childhood Research Association
An investigation of commonly used IBD drugs on autophagy pathway activity and potential therapeutic benefit for treatment of paediatric IBD
Medical Research Council
Risks of developing many adult illnesses are set down as we develop in the womb, hence the environment we experience during fetal life needs to be ‘just right’. Understanding how the fetal environmen...
07 July 2017
Associate Professor of Immunology & Infection / Director of Research, School of Applied Sciences
Teaching Fellow and Lecturer in Biomedical Science
Senior Lecturer, Teaching Fellow, Head of Life Sciences
Donaldson, K., Hibbs, L., Heal, M., Tran, C. L., Lightbody, J., Barlow, P. G., …Stone, V. (2003). Pro-inflammatory interactions between particles, metals and lung cells. In Effects of Air Contaminants on the Respiratory Tract - Interpretations from Molecules to Meta Analysis, 245-258. ISBN 978-3-8167-6478-6
Ross, M., Ingram, L., Taylor, G., Malone, E., Simpson, R. J., West, D., & Florida-James, G. (in press). Older men display elevated levels of senescence-associated exercise responsive CD28 null. Physiological Reports,
Aging is associated with elevated cardiovascular disease risk. As a result of aging, endothelial dysfunction develops, partly due to a reduction in vascular regenerative abili...
Lee, X. J., Pettitt, A. N., & Dancer, S. J. (2018). Quantifying the relative effect of environmental contamination on surgical ward MRSA incidence: An exploratory analysis. Infection, Disease & Health, doi:10.1016/j.idh.2018.02.005. ISSN 2468-0451
Background: To investigate and quantify the contribution of environmental contamination towards methicillin-resistant Staphylococcus aureus (MRSA) incidence observed in a hosp...
Ahmad, S. F., Brown, J. K., Campbell, L. L., Koscielniak, M., Oliver, C., Wheelhouse, N., …Horne, A. W. (2018). Pelvic Chlamydial Infection Predisposes to Ectopic Pregnancy by Upregulating Integrin β1 to Promote Embryo-tubal Attachment. EBioMedicine, doi:10.1016/j.ebiom.2018.02.020
Tubal ectopic pregnancies are a leading cause of global maternal morbidity and mortality. Previous infection with Chlamydia trachomatis is a major risk factor for tubal embryo...
Reid, M., Whatley, V., Spooner, E., Nevill, A. M., Cooper, M., Ramsden, J. J., & Dancer, S. J. (2018). How Does a Photocatalytic Antimicrobial Coating Affect Environmental Bioburden in Hospitals?. Infection Control and Hospital Epidemiology, 39(4), (398-404). doi:10.1017/ice.2017.297. ISSN 0899-823X
BACKGROUND The healthcare environment is recognized as a source for healthcare-acquired infection. Because cleaning practices are often erratic and always intermittent, we hyp...
Staines, K. A., Lee, P. D., Pitsillides, A. A., Staines, K., Madi, K., Javaheri, B., …Pitsillides, A. (2018). A Computed Microtomography Method for Understanding Epiphyseal Growth Plate Fusion. Frontiers in Materials, 4, doi:10.3389/fmats.2017.00048
The epiphyseal growth plate is a developmental region responsible for linear bone growth, in which chondrocytes undertake a tightly regulated series of biological processes. C...
Ikpegbu, E., Basta, L., Clements, D. N., Fleming, R., Vincent, T. L., Buttle, D. J., …Farquharson, C. (2018). FGF-2 promotes osteocyte differentiation through increased E11/podoplanin expression. Journal of Cellular Physiology, doi:10.1002/jcp.26345. ISSN 0021-9541
E11/podoplanin is critical in the early stages of osteoblast-to-osteocyte transitions (osteocytogenesis) however the upstream events which regulate E11 expression are unknown....
Ross, M. D., Malone, E. M., Simpson, R., Cranston, I., Ingram, L., Wright, G. P., …Florida-James, G. D. (2017). Lower Resting and Exercise-Induced Circulating Angiogenic Progenitors and Angiogenic T-Cells in Older Men. American journal of physiology. Heart and circulatory physiology, doi:10.1152/ajpheart.00592.2017. ISSN 0363-6135
Ageing is associated with a dysfunctional endothelial phenotype, as well as reduced angiogenic capabilities. Exercise exerts beneficial effects on the cardiovascular system, p...
Parsonage, B., Hagglund, P. K., Keogh, L., Wheelhouse, N., Brown, R. E., & Dancer, S. J. (2017). Control of Antimicrobial Resistance Requires an Ethical Approach. Frontiers in Microbiology, doi:10.3389/fmicb.2017.02124
Ethical behavior encompasses actions that benefit both self and society. This means that tackling antimicrobial resistance (AMR) becomes an ethical obligation, because the pro...
Martín-Aragón Baudel, M. A. S., Rae, M. T., Darlison, M. G., Poole, A. V., & Fraser, J. A. (2017). Preferential activation of HIF-2α adaptive signalling in neuronal-like cells in response to acute hypoxia. PLoS ONE, 12(10), (e0185664). doi:10.1371/journal.pone.0185664. ISSN 1932-6203
Stroke causes severe neuronal damage as disrupted cerebral blood flow starves neurons of oxygen and glucose. The hypoxia inducible factors (HIF-1α and HIF-2α) orchestrate oxyg...
Mosey, H., Núñez, J., Goring, A., Clarkin, C. E., Staines, K. A., Lee, P. D., …Javaheri, B. (2017). Sost deficiency does not alter bone’s lacunar or vascular porosity in mice. Frontiers in Materials, 4, doi:10.3389/fmats.2017.00027
SCLEROSTIN (Sost) is expressed predominantly in osteocytes acting as a negative regulator of bone formation. In humans, mutations in the SOST gene lead to skeletal overgrowth ...
Velasova, M., Damaso, A., Chengat Prakashbabu, B., Gibbons, J., Wheelhouse, N., Longbottom, D., …Guitian, J. (2017). Herd-level prevalence of selected endemic infectious diseases of dairy cows in Great Britain. Journal of Dairy Science, 100(11), (9215-9233). doi:10.3168/jds.2016-11863. ISSN 0022-0302
n order to implement appropriate and effective disease control programs at national level, up-to-date and unbiased information on disease frequency is needed. The aim of this...
Society for Reproduction and Fertility
Does the gut microbiome play a role in polycystic ovary syndrome?
The University of Edinburgh
Neuromodulation can improve ovarian dysfunction in polycystic ovary syndrome (PCOS). This is achieved by four mechanisms: i) if neural signals are involved in LH action directly their modulation may ...
Undergraduate vacation scholarship application to study the legacy of prenatal programming of polycystic ovary syndrome on postnatal throid function
Polycystic ovary syndrome (PCOS) is common: more than one in 1 in 15 young women has this condition. There are many associated health problems including abnormal periods, miscarriages, infertility, ex...