Lecturer and Research Leader in Biomedical Sciences
Longbottom, D., Livingstone, M., Wheelhouse, N., Ensor, H., Rocchi, M., Maley, S., …Dalgleish, M. (2017). Pathogenic outcome following experimental infection of sheep with Chlamydia abortus variant strains LLG and POS. PLoS ONE. doi:10.1371/journal.pone.0177653. ISSN 1932-6203
This study investigated the pathogenesis of two variant strains (LLG and POS) of Chlamydia abortus, in comparison to a typical wild-type strain (S26/3) which is known to be re...
Staines, K., Javaheri, B., Hohenstein, P., Fleming, R., Ikpegbu, E., Unger, E., …Farquharson, C. (2017). Hypomorphic conditional deletion of E11/Podoplanin reveals a role in osteocyte dendrite elongation. Journal of Cellular Physiology, 232(11), (3006-3019). doi:10.1002/jcp.25999. ISSN 0021-9541
The transmembrane glycoprotein E11/Podoplanin (Pdpn) has been implicated in the initial stages of osteocyte differentiation. However, its precise function and regulatory mecha...
Poulet, B., Liu, K., Plumb, D., Vo, P., Shah, M., Staines, K., …Bou-Gharios, G. (2016). Overexpression of TIMP-3 in Chondrocytes Produces Transient Reduction in Growth Plate Length but Permanently Reduces Adult Bone Quality and Quantity. PLoS ONE. 11(12), e0167971. doi:10.1371/journal.pone.0167971. ISSN 1932-6203
Bone development and length relies on the growth plate formation, which is dependent on degradative enzymes such as MMPs. Indeed, deletion of specific members of this enzyme f...
Chief Scientists Office
We have identified the human cathelicidn LL-37 as having potent direct antiviral activity against human rhinovirus (HRV), together with the capacity to alter death pathways in HRV-infected cells, as a...
Crohn's in Childhood Research Association
An investigation of commonly used IBD drugs on autophagy pathway activity and potential therapeutic benefit for treatment of paediatric IBD
Medical Research Council
Risks of developing many adult illnesses are set down as we develop in the womb, hence the environment we experience during fetal life needs to be ‘just right’. Understanding how the fetal environmen...
Associate Professor of Immunology & Infection / Director of Research, School of Applied Sciences
Lecturer in Biomedical Science
Staines, K. A., Poulet, B., Wentworth, D. N. & Pitsillides, A. A. (2017). The STR/ort mouse model of spontaneous osteoarthritis – an update. Osteoarthritis and Cartilage. 25(6), 802-808. doi:10.1016/j.joca.2016.12.014. ISSN 1063-4584
Osteoarthritis is a degenerative joint disease and a world-wide healthcare burden. Characterized by cartilage degradation, subchondral bone thickening and osteophyte formation...
Houston, D. A., Staines, K. A., MacRae, V. E. & Farquharson, C. (2016). Culture of Murine Embryonic Metatarsals: A Physiological Model of Endochondral Ossification. Journal of Visualized Experiments. doi:10.3791/54978
The fundamental process of endochondral ossification is under tight regulation in the healthy individual so as to prevent disturbed development and/or longitudinal bone growth...
Wheelhouse, N., Flockhart, A., Aitchison, K., Livingstone, M., Finlayson, J., Flachon, V., …Longbottom, D. (2016). Experimental challenge of pregnant cattle with the putative abortifacient Waddlia chondrophila. Scientific Reports. 6, 37150. doi:10.1038/srep37150. ISSN 2045-2322
Waddlia chondrophila is a Gram-negative intracellular bacterial organism that is related to classical chlamydial species and has been implicated as a cause of abortion in catt...
Dancer, S. J. (2016). Antibiotic prescribing: the consequences of getting it wrong. The Journal. 10(2), 62-71
Antibiotics were one of the most important discoveries last century. As with all drugs, however, they are associated with adverse effects. This article reviews how inappropria...
Ross, M., Tormey, P., Ingram, L., Simpson, R., Malone, E., & Florida-James, G. (2016). A 10 km time trial running bout acutely increases the number of angiogenic T cells in the peripheral blood compartment of healthy males: Acute exercise mobilizes angiogenic T cells. Experimental Physiology, 101(10), (1253-1264). doi:10.1113/ep085771. ISSN 0958-0670
What is the central question of the study?
Are CD31+ angiogenic T (TANG) cells preferentially mobilized in response to acute exercise?
What is the main finding an...
Dancer, S. J. (2016). Dos and don’ts for hospital cleaning. Current Opinion in Infectious Diseases. 29(4), 415-423. doi:10.1097/qco.0000000000000289. ISSN 0951-7375
Purpose of review: More evidence is emerging on the role of cleaning and decontamination for reducing hospital-acquired infection. Timely and adequate removal of environmental...
Houston, D. A., Myers, K., MacRae, V. E., Staines, K. A. & Farquharson, C. (2016). The Expression of PHOSPHO1, nSMase2 and TNAP is Coordinately Regulated by Continuous PTH Exposure in Mineralising Osteoblast Cultures. Calcified Tissue International. 99(5), 510-524. doi:10.1007/s00223-016-0176-9. ISSN 0171-967X
Sustained exposure to high levels of parathyroid hormone (PTH), as observed in hyperparathyroidism, are catabolic to bone. The increase in the RANKL/OPG ratio in response to c...
Barlow, P. G., Coyle, C., Wheelhouse, N., Jacques, M., Longbottom, D., Svoboda, P., …Colin Duncan, W. (2016). Ovine trophoblasts express cathelicidin host defence peptide in response to infection. Journal of Reproductive Immunology. 117, 10-16. doi:10.1016/j.jri.2016.06.006. ISSN 0165-0378
Cationic host defence peptides (CHDP; also known as antimicrobial peptides) are key components of the immune response in the female reproductive tract. The role of the placent...
Sousa, F. H., Casanova, V., Stevens, C., & Barlow, P. G. (2016). Antiviral host defence peptides. In R. M. Epand (Ed.), Host Defense Peptides and Their Potential as Therapeutic Agents, 57-94. Cham, Switzerland: Springer Verlag. doi:10.1007/978-3-319-32949-9_3
The on going global mortality and morbidity associated with viral pathogens highlights the need for the continued development of effective, novel antiviral molecules. The anti...
Simpson, R. J., Graham, S. M., Connaboy, C., Clement, R., Pollonini, L. & Florida-James, G. (2016). Blood lactate thresholds and walking/running economy are determinants of backpack-running performance in trained soldiers. Applied Ergonomics. 58, 566-572. doi:10.1016/j.apergo.2016.04.010. ISSN 0003-6870
We developed a standardized laboratory treadmill protocol for assessing physiological responses to a simulated backpack load-carriage task in trained soldiers, and assessed th...
Staines, K. A., Madi, K., Mirczuk, S. M., Parker, S., Burleigh, A., Poulet, B., …Pitsillides, A. A. (2016). Endochondral Growth Defect and Deployment of Transient Chondrocyte Behaviors Underlie Osteoarthritis Onset in a Natural Murine Model. Arthritis and Rheumatology. 68(4), 880-891. doi:10.1002/art.39508. ISSN 2326-5191
To explore whether aberrant transient chondrocyte behaviors occur in the joints of STR/Ort mice (which spontaneously develop osteoarthritis [OA]) and whether they a...
Storrie, S., Longbottom, D., Barlow, P. G. & Wheelhouse, N. (2016). MAPK activation is essential for Waddlia chondrophila induced CXCL8 expression in human epithelial cells. PLoS ONE. 11, e0152193. doi:10.1371/journal.pone.0152193. ISSN 1932-6203
Waddlia chondrophila (W. chondrophila) is an emerging agent of respiratory and reproductive
disease in humans and cattle. The organism is a member of the order Chla...
The University of Edinburgh
Neuromodulation can improve ovarian dysfunction in polycystic ovary syndrome (PCOS). This is achieved by four mechanisms: i) if neural signals are involved in LH action directly their modulation may ...
Society for Reproduction and Fertility
Undergraduate vacation scholarship application to study the legacy of prenatal programming of polycystic ovary syndrome on postnatal throid function
Polycystic ovary syndrome (PCOS) is common: more than one in 1 in 15 young women has this condition. There are many associated health problems including abnormal periods, miscarriages, infertility, ex...