Associate Professor of Immunology & Infection / Director of Research, School of Applied Sciences
Findlay, F., Pohl, J., Svoboda, P., Shakamuri, P., McLean, K., Inglis, N. F., …Barlow, P. G. (2017). Carbon Nanoparticles Inhibit the Antimicrobial Activities of the Human Cathelicidin LL-37 through Structural Alteration. Journal of Immunology, 199(7), (2483-2490). doi:10.4049/jimmunol.1700706. ISSN 0022-1767
Host defense peptides, also known as antimicrobial peptides, are key elements of innate host defense. One host defense peptide with well-characterized antimicrobial activity i...
Barlow, P. G., Coyle, C., Wheelhouse, N., Jacques, M., Longbottom, D., Svoboda, P., …Colin Duncan, W. (2016). Ovine trophoblasts express cathelicidin host defence peptide in response to infection. Journal of Reproductive Immunology. 117, 10-16. doi:10.1016/j.jri.2016.06.006. ISSN 0165-0378
Cationic host defence peptides (CHDP; also known as antimicrobial peptides) are key components of the immune response in the female reproductive tract. The role of the placent...
Hart, E., McEwan, C., Timmis, J. & Hone, A. (2011). Advances in artificial immune systems. Evolutionary Intelligence. 4, 67-68. doi:10.1007/s12065-011-0058-z. ISSN 1864-5909
The field of Artificial Immune Systems (AIS) derives inspiration from processes and mechanisms apparent in the biological immune system. After early applications of this parad...
Notley, C. A., Brown, M. A., Wright, G. P. & Ehrenstein, M. R. (2011). Natural IgM Is Required for Suppression of Inflammatory Arthritis by Apoptotic Cells. The journal of immunology : official journal of the American Association of Immunologists. 186(8), 4967-4972. doi:10.4049/jimmunol.1003021. ISSN 1550-6606
The clearance of dying cells is vital for re-establishing tolerance during inflammation and has potent immunoregulatory consequences. Because natural IgM plays a key role in t...
Timmis, J., Andrews, P., & Hart, E. (2010). On artificial immune systems and swarm intelligence. Swarm Intelligence, 4(4), 247-273. doi:10.1007/s11721-010-0045-5
This position paper explores the nature and role of two bio-inspired paradigms, namely Artificial Immune Systems (AIS) and Swarm Intelligence (SI). We argue that there are man...
Van Limbergen, J., Stevens, C., Nimmo, E. R., Wilson, D. C. & Satsangi, J. (2009). Autophagy: from basic science to clinical application. Mucosal immunology. 2(4), 315-330. doi:10.1038/mi.2009.20. ISSN 1933-0219
Autophagy is a cellular pathway involved in protein and organelle degradation, which is likely to represent an innate adaptation to starvation. In times of nutrient deficiency...
Wheelhouse, N., Wattegedera, S., Stanton, J., Maley, S., Watson, D., Jepson, C., …Entrican, G. (2009). Ovine trophoblast is a primary source of TNFalpha during Chlamydophila abortus infection. Journal of Reproductive Immunology. 80(1-2), 49-56. doi:10.1016/j.jri.2008.12.003. ISSN 0165-0378
Chlamydophila abortus is a Gram-negative obligate intracellular bacterium that causes infectious abortion in sheep (ovine enzootic abortion, OEA) and humans. Infected placenta...
Wheelhouse, N., Wattegedera, S., Fleming, D., Fitch, P., Kelly, R. & Entrican, G. (2008). Chlamydia trachomatis and Chlamydophila abortus induce the expression of secretory leukocyte protease inhibitor in cells of the human female reproductive tract. Microbiology and Immunology. 52(9), 465-468. doi:10.1111/j.1348-0421.2008.00058.x. ISSN 0385-5600
C. trachomatis and C. abortus are related Gram-negative intracellular bacteria that cause reproductive failure due to infertility (C. trachomatis) or abortion (C. abortus). Th...
Hart, E., Ross, P., Webb, A., & Lawson, A. (2003). A role for immunology in 'next generation' robots. In J. Timmis, P. Bentley, & E. Hart (Eds.), Artificial Immune Systems. ICARIS 2003, 46-56. doi:10.1007/978-3-540-45192-1_5
Much of current robot research is about learning tasks in which the task to be achieved is pre-specified, a suitable technology for the task is chosen and the learning process...
Hart, E., Read, M., McEwan, C., Aickelin, U. & Greensmith, J. (2012). On the role of the AIS practitioner. In Liò, P., Miglino, O., Nicosia, G., Nolfi, S. & Pavone, M. (Eds.). Advances in Artificial Life, ECAL 2013, 891-892. doi:10.7551/978-0-262-31709-2-ch132
Cognisant of the gulf between engineers and immunologists
that currenty hinders a truly inter-disciplinary approach to
the field of Artificial Immune Systems (AIS), we propose...