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Ectopic lymphoid tissue formation in the lungs of mice infected with Chlamydia pneumoniae is associated with epithelial macrophage inflammatory protein-2/CXCL2 expression

Journal Article
Fitch, P., Wheelhouse, N., Bowles, P., Paterson, M., Longbottom, D., Entrican, G., & Howie, S. (2010)
Ectopic lymphoid tissue formation in the lungs of mice infected with Chlamydia pneumoniae is associated with epithelial macrophage inflammatory protein-2/CXCL2 expression. Clinical and Experimental Immunology, 162(2), 372-378. https://doi.org/10.1111/j.1365-2249.2010.04231.x
Infection with Chlamydia pneumoniae (Cp) accounts for around 10% of community acquired bacterial pneumonia and has been associated with other chronic inflammatory conditions. ...

Intranasal infection with Chlamydia abortus induces dose-dependent latency and abortion in sheep

Journal Article
Longbottom, D., Livingstone, M., Maley, S., van der Zon, A., Rocchi, M., Wilson, K., …Buxton, D. (2013)
Intranasal infection with Chlamydia abortus induces dose-dependent latency and abortion in sheep. PLOS ONE, 8(2), https://doi.org/10.1371/journal.pone.0057950
BACKGROUND: Latency is a key feature of the animal pathogen Chlamydia abortus, where infection remains inapparent in the non-pregnant animal and only becomes evident during a ...

Interferon-γ polymorphisms correlate with duration of survival in pancreatic cancer

Journal Article
Halma, M., Wheelhouse, N., Barber, M., Powell, J., Fearon, K., & Ross, J. (2004)
Interferon-γ polymorphisms correlate with duration of survival in pancreatic cancer. Human Immunology, 65(11), 1405-1408. https://doi.org/10.1016/j.humimm.2004.08.184
Despite progress in diagnosis and staging, pancreatic cancer still has a poor prognosis and it remains difficult to predict duration of survival in advanced pancreatic cancer....

Genome sequencing and comparative analysis of three Chlamydia pecorum strains associated with different pathogenic outcomes

Journal Article
Sait, M., Livingstone, M., Clark, E. M., Wheelhouse, N., Spalding, L., Markey, B., …Longbottom, D. (2014)
Genome sequencing and comparative analysis of three Chlamydia pecorum strains associated with different pathogenic outcomes. BMC Genomics, 15, 23. https://doi.org/10.1186/1471-2164-15-23
BACKGROUND: Chlamydia pecorum is the causative agent of a number of acute diseases, but most often causes persistent, subclinical infection in ruminants, swine and birds. In t...

Genetic variability of Chlamydophila abortus strains assessed by PCR-RFLP analysis of polymorphic membrane protein-encoding genes

Journal Article
Saita, M., Clarka, E. M., Wheelhouse, N., Spalding, L., Livingstone, M., Sachse, K., …Longbottom, D. (2011)
Genetic variability of Chlamydophila abortus strains assessed by PCR-RFLP analysis of polymorphic membrane protein-encoding genes. Veterinary Microbiology, 151(3-4), 284-90. https://doi.org/10.1016/j.vetmic.2011.03.005
This study used PCR-RFLP to investigate the genetic variability of pmp-encoding genes from fifty-two Chlamydophila abortus (C. abortus) strains originating from abortion cases...

Genome Sequence of Lawsonia intracellularis Strain N343, Isolated from a Sow with Hemorrhagic Proliferative Enteropathy

Journal Article
Sait, M., Aitchison, K., Wheelhouse, N., Wilson, K., Alex Lainson, F., Longbottom, D., & Smith, D. G. E. (2013)
Genome Sequence of Lawsonia intracellularis Strain N343, Isolated from a Sow with Hemorrhagic Proliferative Enteropathy. Genome Announcements, 1(1), https://doi.org/10.1128/genomeA.00027-13
Lawsonia intracellularis is the etiological agent of proliferative enteropathy (PE), causing mild or acute hemorrhagic diarrhea in infected animals. Here we report the genome ...

Identification, sequencing and molecular analysis of Chp4, a novel chlamydiaphage of Chlamydophila abortus belonging to the family Microviridae

Journal Article
Sait, M., Livingstone, M., Graham, R., Inglis, N. F., Wheelhouse, N., & Longbottom, D. (2011)
Identification, sequencing and molecular analysis of Chp4, a novel chlamydiaphage of Chlamydophila abortus belonging to the family Microviridae. Journal of General Virology, 92(7), 1733-1737. https://doi.org/10.1099/vir.0.031583-0
Members of the family Microviridae have been identified in a number of chlamydial species infecting humans (phage CPAR39 in Chlamydophila pneumoniae), other mammals (phiCPG1 i...

Immunological paradigms and the pathogenesis of ovine chlamydial abortion

Journal Article
Entrican, G., Wattegedera, S., Wheelhouse, N., Allan, A., & Rocchi, M. (2010)
Immunological paradigms and the pathogenesis of ovine chlamydial abortion. American Journal of Reproductive Immunology, 64(4), 287-294. https://doi.org/10.1111/j.1600-0897.2010.00907.x
Successful mammalian pregnancy involves complex immunological interactions between the mother and foetus that are not yet fully understood. A number of immunological paradigms...

An unusual presentation of Chlamydia pneumoniaeinfection in a Royal Python (Python regius)

Journal Article
Cope, I., Wheelhouse, N., Pocknell, A., Dagleish, M., & Summers, B. (2014)
An unusual presentation of Chlamydia pneumoniaeinfection in a Royal Python (Python regius). Veterinary record case reports, 2(1), https://doi.org/10.1136/vetreccr-2014-000086
Chlamydia species are a relatively newly recognised and emerging pathogen in reptile species. Chlamydia pneumoniae has been reported to cause infections in several snake speci...

Chlamydia trachomatis infection of human endometrial stromal cells induces defective decidualisation and chemokine release

Journal Article
Giakoumelou, S., Wheelhouse, N., Brown, J., Wade, J., Simitsidellis, I., Gibson, D., …Horne, A. W. (2017)
Chlamydia trachomatis infection of human endometrial stromal cells induces defective decidualisation and chemokine release. Scientific Reports, 7(1), https://doi.org/10.1038/s41598-017-02223-z
Miscarriage affects ~20% of pregnancies and 30 maternal infections account for ~15% of early miscarriages. Chlamydia trachomatis (Ct) has been associated with miscarriage but ...
9 results

Supporting Evidence Based Interventions

2017 - 2019
Supporting Evidence Based Interventions
Funder: University of Glasgow | Value: £6,500

Acceptability of extragenital Chlamydia testing

2017 - 2018
Chlamydia trachomatis is the most common sexually transmitted infection in Scotland, and has significant long‐term consequences to reproductive health. Recent studies suggest that in addition to the g...
Funder: Chief Scientists Office | Value: £27,998

Development of a UV-C hand-sanitiser unit

2017 - 2017
Development of a UV-C hand-sanitiser unit
Funder: Scottish Funding Council | Value: £5,000

Rutherford fund Strategic Partner Grant

2018 - 2019
Rutherford Fellows, will work in project areas related to food safety (Pathogen detection, AMR etc) and food spoilage. Rutherford Fund, are funded by BEIS and the scheme is being managed by Universit...
Funder: Department for Business, Energy & Industrial Strategy | Value: £39,800

Mechanism of Chlamydia induced progesterone resistance

2018 - 2019
Chlamydia trachomatis is the most common sexually-transmitted infection in the world, and is associated with miscarriage, pre-term birth and infertility. However, the understanding of the mechanisms t...
Funder: Society for Reproduction and Fertility | Value: £12,034

EEID travel award: Understanding transmission dynamics for bacterial zoonoses in humans, goats and camels among pastoral communities in Northern Kenya

2019 - 2019
EEID travel award: Understanding transmission dynamics for bacterial zoonoses in humans, goats and camels among pastoral communities in Northern Kenya
Funder: Biotechnology and Biological Sciences Research Council | Value: £1,960

Prevalence of Brucellosis and Q-fever in livestock within the Ashanti region of Ghana

2020 - 2021
To determine the seroprevalence of abortifacient zoonoses (Brucellosis and Coxiellosis) in small ruminants within the Ashanti region of Ghana
Funder: Microbiology Society | Value: £2,530

Investigating the prevalence and diversity of bacterial endosymbionts in Scottish hoverfly populations

2020 - 2021
Investigating the prevalence and diversity of bacterial endosymbionts in Scottish hoverfly populations
Funder: Carnegie Trust for the Universities of Scotland | Value: £13,549

Direct and paracrine effects of Chlamydia infection on decidualisation of endometrial stromal cells

2018 - 2018
SRF summer studentship
Funder: Society for Reproduction and Fertility | Value: £2,750

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