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Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice

Journal Article
Killick, R., Scales, G., Leroy, K., Causevic, M., Hooper, C., Irvine, E. E., …Lovestone, S. (2009)
Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice. Biochemical and Biophysical Research Communications, 386(1), 257-262. https://doi.org/10.1016/j.bbrc.2009.06.032
As impaired insulin signalling (IIS) is a risk factor for Alzheimer's disease we crossed mice (Tg2576) over-expressing human amyloid precursor protein (APP), with insulin rece...

Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster

Journal Article
Bjedov, I., Toivonen, J. M., Kerr, F., Slack, C., Jacobson, J., Foley, A., & Partridge, L. (2010)
Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster. Cell Metabolism, 11(1), 35-46. https://doi.org/10.1016/j.cmet.2009.11.010
The target of rapamycin (TOR) pathway is a major nutrient-sensing pathway that, when genetically downregulated, increases life span in evolutionarily diverse organisms includi...

Hyperphosphorylation of tau and neurofilaments and activation of CDK5 and ERK1/2 in PTEN-deficient cerebella

Journal Article
Nayeem, N., Kerr, F., Naumann, H., Linehan, J., Lovestone, S. & Brandner, S. (2007)
Hyperphosphorylation of tau and neurofilaments and activation of CDK5 and ERK1/2 in PTEN-deficient cerebella. Molecular and Cellular Neuroscience. 34(3), 400-408. doi:10.1016/j.mcn.2006.11.014. ISSN 1044-7431
Inherited mutations to the tumor suppressor PTEN sporadically lead to cerebellar gangliocytoma characterized by migration defects. This has been modeled by CNS-specific PTEN a...