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Maternal nutrient restriction in early pregnancy programs hepatic mRNA expression of growth-related genes and liver size in adult male sheep

Journal Article
Hyatt, M. A., Gopalakrishnan, G. S., Bispham, J., Gentili, S., McMillen, I. C., Rhind, S. M., …Symonds, M. E. (2007)
Maternal nutrient restriction in early pregnancy programs hepatic mRNA expression of growth-related genes and liver size in adult male sheep. Journal of Endocrinology, 192(1), 87-97. https://doi.org/10.1677/joe.1.06801
The liver is a major metabolic and endocrine organ of critical importance in the regulation of growth and metabolism. Its function is determined by a complex interaction of nu...

Steroid signalling in the ovarian surface epithelium

Journal Article
Rae, M. T., & Hillier, S. G. (2005)
Steroid signalling in the ovarian surface epithelium. Trends in Endocrinology and Metabolism, 16(7), 327-333. https://doi.org/10.1016/j.tem.2005.07.002
Human ovarian surface epithelium (HOSE) undergoes serial injury-repair with each ovulation, which is probably why most ovarian epithelial cancers arise there. Considering the ...

Impact of maternal undernutrition and fetal number on glucocorticoid, growth hormone and insulin-like growth factor receptor mRNA abundance in the ovine fetal kidney

Journal Article
Brennan, K. A., Gopalakrishnan, G. S., Kurlak, L., Rhind, S. M., Kyle, C. E., Brooks, A. N., …Symonds, M. E. (2005)
Impact of maternal undernutrition and fetal number on glucocorticoid, growth hormone and insulin-like growth factor receptor mRNA abundance in the ovine fetal kidney. Reproduction, 129, 151-159. https://doi.org/10.1530/rep.1.00229
Epidemiological and animal studies strongly indicate that the environment experienced in utero determines, in part, an individual’s likelihood of developing cardiovascular dis...

Programming of adult cardiovascular function after early maternal undernutrition in sheep

Journal Article
Gopalakrishnan, G. S., Gardner, D. S., Rhind, S. M., Rae, M. T., Kyle, C. E., Brooks, A. N., …Symonds, M. E. (2004)
Programming of adult cardiovascular function after early maternal undernutrition in sheep. American journal of physiology: regulatory, integrative and comparative physiology, 287(1), R12-R20. https://doi.org/10.1152/ajpregu.00687.2003
The prenatal nutritional environment influences the subsequent risk of hypertension in adulthood. Animal studies have used, generally, the rat as a model species to illustrate...

Effects of prenatal undernutrition on emotional reactivity and cognitive flexibility in adult sheep

Journal Article
Erhard, H. W., Boissy, A., Rae, M. T., & Rhind, S. M. (2004)
Effects of prenatal undernutrition on emotional reactivity and cognitive flexibility in adult sheep. Behavioural Brain Research, 151(1-2), 25-35. https://doi.org/10.1016/j.bbr.2003.08.003
The experiment reported was designed to test two hypotheses: that prenatal undernutrition (a) increases emotional reactivity and (b) impairs cognitive flexibility in sheep. Th...

Environmental influences on the fetus and neonate—timing, mechanisms of action and effects on subsequent adult function

Journal Article
Rhind, S., Rae, M., & Brooks, A. (2003)
Environmental influences on the fetus and neonate—timing, mechanisms of action and effects on subsequent adult function. Domestic Animal Endocrinology, 25(1), 3-11. https://doi.org/10.1016/S0739-7240%2803%2900041-9
Environmental influences on fetal and neonatal development can affect neural, reproductive, immune and cardiovascular function in adult humans and animals. The effects can be ...

Non-genomic steroid receptors in the bovine ovary

Journal Article
Bramley, T., Menzies, G., Rae, M., & Scobie, G. (2002)
Non-genomic steroid receptors in the bovine ovary. Domestic Animal Endocrinology, 23(1-2), 3-12. https://doi.org/10.1016/S0739-7240%2802%2900140-6
Over the last few years, rapid and physiologically important non-genomic actions of all classes of steroid hormones have been described in many cell types. A putative non-geno...

The effects of undernutrition, in utero, on reproductive function in adult male and female sheep

Journal Article
Rae, M., Kyle, C., Miller, D., Hammond, A., Brooks, A., & Rhind, S. (2002)
The effects of undernutrition, in utero, on reproductive function in adult male and female sheep. Animal Reproduction Science, 72(1-2), 63-71. https://doi.org/10.1016/S0378-4320%2802%2900068-4
The aim of this study was to determine the effects of maternal undernutrition during pregnancy on adult reproductive function in male and female offspring. Groups of ewes were...

Synthesis and Characterization of 111In−DTPA−N-TIMP-2: A Radiopharmaceutical for Imaging Matrix Metalloproteinase Expression

Journal Article
Giersing, B. K., Rae, M. T., CarballidoBrea, M., Williamson, R. A., & Blower, P. J. (2001)
Synthesis and Characterization of 111In−DTPA−N-TIMP-2: A Radiopharmaceutical for Imaging Matrix Metalloproteinase Expression. Bioconjugate Chemistry, 12, 964-971. https://doi.org/10.1021/bc010028f
The matrix metalloproteinases (MMPs) are enzymes involved in the turnover of the extracellular matrix. Their overexpression in tumors is implicated in the metastatic process a...

Stimulation of specific binding of [3H]-progesterone to bovine luteal cell-surface membranes: specificity of digitonin

Journal Article
Menzies, G., Howland, K., Rae, M., & Bramley, T. (1999)
Stimulation of specific binding of [3H]-progesterone to bovine luteal cell-surface membranes: specificity of digitonin. Molecular and Cellular Endocrinology, 153, 57-69. https://doi.org/10.1016/S0303-7207%2899%2900091-X
Non-genomic actions of progesterone have been described in the ovary, and luteal membranes of several species have been shown to possess specific binding sites for [3H]-proges...