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Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice

Journal Article
Killick, R., Scales, G., Leroy, K., Causevic, M., Hooper, C., Irvine, E. E., …Lovestone, S. (2009)
Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice. Biochemical and Biophysical Research Communications, 386(1), 257-262. https://doi.org/10.1016/j.bbrc.2009.06.032
As impaired insulin signalling (IIS) is a risk factor for Alzheimer's disease we crossed mice (Tg2576) over-expressing human amyloid precursor protein (APP), with insulin rece...

Avian Urine: Its Potential as a Non-Invasive Biomonitor of Environmental Metal Exposure in Birds

Journal Article
Clapp, J. B., Bevan, R. M., & Singleton, I. (2012)
Avian Urine: Its Potential as a Non-Invasive Biomonitor of Environmental Metal Exposure in Birds. Water, air, and soil pollution, 223(7), 3923-3938. https://doi.org/10.1007/s11270-012-1161-1
Current non-invasive biomonitoring techniques to measure heavy metal exposure in free ranging birds using eggs, feathers and guano are problematic because essential metals cop...

Cationic host defense peptides; novel antimicrobial therapeutics against Category A pathogens and emerging infections

Journal Article
Findlay, F., Proudfoot, L., Stevens, C., & Barlow, P. G. (2016)
Cationic host defense peptides; novel antimicrobial therapeutics against Category A pathogens and emerging infections. Pathogens and Global Health, 110(4-5), 137-147. https://doi.org/10.1080/20477724.2016.1195036
Cationic Host Defense Peptides (HDP, also known as antimicrobial peptides) are crucial components of the innate immune system and possess broad-spectrum antibacterial, antivir...

Carbon black nanoparticles induce type II epithelial cells to release chemotaxins for alveolar macrophages.

Journal Article
Barlow, P. G., Clouter-Baker, A., Donaldson, K., MacCallum, J., & Stone, V. (2005)
Carbon black nanoparticles induce type II epithelial cells to release chemotaxins for alveolar macrophages. Particle and fibre toxicology, 2(1), 11-24. https://doi.org/10.1186/1743-8977-2-11
Background - Alveolar macrophages are a key cell in dealing with particles deposited in the lungs and in determining the subsequent response to that particle exposure. Nanopar...

Characterisation of glutamine fructose-6-phosphate amidotransferase (EC 2.6.1.16) and N-acetylglucosamine metabolism in Bifidobacterium

Journal Article
Aïssi, E., Foley, S., Stolarczyk, E., Mouni, F., Brassart, C., Vidal, O., …Krzewinski, F. (2008)
Characterisation of glutamine fructose-6-phosphate amidotransferase (EC 2.6.1.16) and N-acetylglucosamine metabolism in Bifidobacterium. Archives of Microbiology, 189(2), 157-167. doi:10.1007/s00203-007-0307-9
Bifidobacterium bifidum, in contrast to other bifido-bacterial species, is auxotrophic for N-acetylglucosamine. Growth experiments revealed assimilation of radiolabelled N-ace...

Chapter Five - Review: Metal-Based Nanoparticles; Size, Function, and Areas for Advancement in Applied Microbiology

Book Chapter
Sweet, M. J., Chessher, A., & Singleton, I. (2012)
Chapter Five - Review: Metal-Based Nanoparticles; Size, Function, and Areas for Advancement in Applied Microbiology. Advances in Applied Microbiology, (113-142). Elsevier. https://doi.org/10.1016/B978-0-12-394381-1.00005-2
Abstract Nanoparticles (NPs) are attracting increased attention in commerce and applied microbiology due to their antimicrobial activity, high electrical conductivity, and opt...

The life cycle of Anisakis simplex in the Norwegian Deep (northern North Sea)

Journal Article
Palm, H. W., Rueckert, S., & Piatkowski, U. (2004)
The life cycle of Anisakis simplex in the Norwegian Deep (northern North Sea). Parasitology Research, 94(1), (1-9). doi:10.1007/s00436-004-1154-0. ISSN 0932-0113
Copepoda (Calanus finmarchicus n=1,722, Paraeuchaeta norvegica n=1,955), Hyperiidae (n=3,019), Euphausiacea (Meganyctiphanes norvegica n=4,780), and the fishes Maurolicus muel...

Starvation/stationary-phase survival of Rhodococcus erythropolis SQ1: a physiological and genetic analysis.

Journal Article
Fanget, N. V. J., & Foley, S. (2011)
Starvation/stationary-phase survival of Rhodococcus erythropolis SQ1: a physiological and genetic analysis. Archives of Microbiology, 193, 1-13. https://doi.org/10.1007/s00203-010-0638-9
The adaptation of Rhodocccus erythropolis SQ1 to energy and carbon starvation was investigated in terms of both the capacity to survive starvation and the contribution of a nu...

Waddlia chondrophila Infects and Multiplies in Ovine Trophoblast Cells Stimulating an Inflammatory Immune Response

Journal Article
Wheelhouse, N., Coyle, C., Barlow, P. G., Mitchell, S., Greub, G., Baszler, T., …Longbottom, D. (2014)
Waddlia chondrophila Infects and Multiplies in Ovine Trophoblast Cells Stimulating an Inflammatory Immune Response. PLOS ONE, 9(7), e102386. https://doi.org/10.1371/journal.pone.0102386
BACKGROUND Waddlia chondrophila (W. chondrophila) is an emerging abortifacient organism which has been identified in the placentae of humans and cattle. The organism is a mem...

Tuberous sclerosis-2 (TSC2) regulates the stability of death-associated protein kinase-1 (DAPK) through a lysosome-dependent degradation pathway.

Journal Article
Hupp, T., Lin, Y., Henderson, P., Pettersson, S., Satsangi, J., Hupp, T. R., & Stevens, C. (2010)
Tuberous sclerosis-2 (TSC2) regulates the stability of death-associated protein kinase-1 (DAPK) through a lysosome-dependent degradation pathway. FEBS Journal, 278(2), 354-370. https://doi.org/10.1111/j.1742-4658.2010.07959.x
We previously identified a novel interaction between tuberous sclerosis-2 (TSC2) and death-associated protein kinase-1 (DAPK), the consequence being that DAPK catalyses the in...