Research explorer tool

13 results

Mutations in the waaR Gene of Escherichia coli Which Disrupt Lipopolysaccharide Outer Core Biosynthesis Affect Cell Surface Retention of Group 2 Capsular Polysaccharides.

Journal Article
Taylor, C. M., Goldrick, M., Lord, L., & Roberts, I. S. (2006)
Mutations in the waaR Gene of Escherichia coli Which Disrupt Lipopolysaccharide Outer Core Biosynthesis Affect Cell Surface Retention of Group 2 Capsular Polysaccharides. Journal of Bacteriology, 188(3), 1165-1168. https://doi.org/10.1128/JB.188.3.1165-1168.2006
On the basis of increased resistance to K5 capsule-specific bacteriophage, a waaR transposon mutant defective in the biosynthesis of lipopolysaccharide outer core was isolated...

Understanding the attitudes and acceptability of extra-genital Chlamydia testing in young women: evaluation of a feasibility study

Journal Article
Brown, S., Paterson, C., Dougall, N., Cameron, S., & Wheelhouse, N. (in press)
Understanding the attitudes and acceptability of extra-genital Chlamydia testing in young women: evaluation of a feasibility study. BMC Public Health, 19(1), https://doi.org/10.1186/s12889-019-7313-0
Background Chlamydia trachomatis (C. trachomatis) is the most common bacterial sexually transmitted infection in the UK. Recent studies suggest that in addition to the genital...

Nanoparticle interactions with zinc and iron: Implications for toxicology and inflammation

Journal Article
Wilson, M. R., Foucaud, L., Barlow, P. G., Hutchison, G. R., Sales, J., Simpson, R. J., & Stone, V. (2007)
Nanoparticle interactions with zinc and iron: Implications for toxicology and inflammation. Toxicology and Applied Pharmacology, 225(1), 80-89. https://doi.org/10.1016/j.taap.2007.07.012
Particulate air pollution (PM10) consists of a mixture of components, including nanoparticles and metals. Studies from our laboratory have demonstrated that transition metals ...

Serum exposed to nanoparticle carbon black displays increased potential to induce macrophage migration

Journal Article
Barlow, P., Donaldson, K., MacCallum, J., Clouter, A., & Stone, V. (2005)
Serum exposed to nanoparticle carbon black displays increased potential to induce macrophage migration. Toxicology Letters, 155(3), 397-401. https://doi.org/10.1016/j.toxlet.2004.11.006
Objective: To assess whether fine and ultrafine particles (nanoparticles) have the capacity to activate factors in serum that would induce macrophage migration. This is a mode...

Ferlavirus-related deaths in a collection of viperid snakes

Journal Article
Flach, E. J., Dagleish, M. P., Feltrer, Y., Gill, I. S., Marschang, R. E., Masters, N., …Wheelhouse, N. M. (2018)
Ferlavirus-related deaths in a collection of viperid snakes. Journal of Zoo and Wildlife Medicine, 49(4), 983-995. https://doi.org/10.1638/2017-0223.1
Between June and October 2013 26 snakes of six viperid species kept in two adjoining rooms died (n = 16) or were euthanized on medical (1) or welfare grounds (9). Two were fro...

Immunological homeostasis at the ovine placenta may reflect the degree of maternal foetal interaction

Journal Article
Wattegedera, S. R., Doull, L. E., Goncheva, M. I., Wheelhouse, N., Watson, D. M., Pearce, J., …Entrican, G. (2019)
Immunological homeostasis at the ovine placenta may reflect the degree of maternal foetal interaction. Frontiers in Immunology, 9, https://doi.org/10.3389/fimmu.2018.03025
Successful mammalian pregnancies are a result of complex physiological, endocrinological and immunological processes that combine to create an environment where the mother is ...

Experimental challenge of pregnant cattle with the putative abortifacient Waddlia chondrophila

Journal Article
Wheelhouse, N., Flockhart, A., Aitchison, K., Livingstone, M., Finlayson, J., Flachon, V., …Longbottom, D. (2016)
Experimental challenge of pregnant cattle with the putative abortifacient Waddlia chondrophila. Scientific Reports, 6, 37150. https://doi.org/10.1038/srep37150
Waddlia chondrophila is a Gram-negative intracellular bacterial organism that is related to classical chlamydial species and has been implicated as a cause of abortion in catt...

Control of Antimicrobial Resistance Requires an Ethical Approach

Journal Article
Parsonage, B., Hagglund, P. K., Keogh, L., Wheelhouse, N., Brown, R. E., & Dancer, S. J. (2017)
Control of Antimicrobial Resistance Requires an Ethical Approach. Frontiers in Microbiology, 8, https://doi.org/10.3389/fmicb.2017.02124
Ethical behavior encompasses actions that benefit both self and society. This means that tackling antimicrobial resistance (AMR) becomes an ethical obligation, because the pro...

Listeria monocytogenes relA and hpt Mutants Are Impaired in Surface-Attached Growth and Virulence

Journal Article
Taylor, C. M., Beresford, M., Epton, H. A. S., Sigee, D. C., Shama, G., Andrew, P. W., & Roberts, I. S. (2002)
Listeria monocytogenes relA and hpt Mutants Are Impaired in Surface-Attached Growth and Virulence. Journal of Bacteriology, 184(3), 621-628. https://doi.org/10.1128/JB.184.3.621-628.2002
We describe here the identification and characterization of two Listeria monocytogenes (Tn917-LTV3) relA and hpt transposon insertion mutants that were impaired in growth afte...

The Effects of Air Pollution Particles on Clearance Mechanisms Within the Lung

Thesis
Barlow, P. G. The Effects of Air Pollution Particles on Clearance Mechanisms Within the Lung. (Thesis)
Edinburgh Napier University. Retrieved from http://researchrepository.napier.ac.uk/Output/1052591
The effects of inhaled aIr pollution particles on lung clearance mechanisms is an important factor in understanding how the mammalian lung deals with such pollutants and, as s...
7 results

Acceptability of extragenital Chlamydia testing

2017 - 2018
Chlamydia trachomatis is the most common sexually transmitted infection in Scotland, and has significant long‐term consequences to reproductive health. Recent studies suggest that in addition to the g...
Funder: Chief Scientists Office | Value: £27,998

Development of a UV-C hand-sanitiser unit

2017 - 2017
Development of a UV-C hand-sanitiser unit
Funder: Scottish Funding Council | Value: £5,000

TRANSFORM - Education reform project – Improving Research capability in the Sri Lankan Higher Education sector.

2018 - 2019
TRANSFORM - Education reform project – Improving Research capability in the Sri Lankan Higher Education sector.
Funder: British Council | Value: £75,000

Rutherford fund Strategic Partner Grant

2018 - 2019
Rutherford Fellows, will work in project areas related to food safety (Pathogen detection, AMR etc) and food spoilage. Rutherford Fund, are funded by BEIS and the scheme is being managed by Universit...
Funder: Department for Business, Energy & Industrial Strategy | Value: £39,800

Mechanism of Chlamydia induced progesterone resistance

2018 - 2019
Chlamydia trachomatis is the most common sexually-transmitted infection in the world, and is associated with miscarriage, pre-term birth and infertility. However, the understanding of the mechanisms t...
Funder: Society for Reproduction and Fertility | Value: £12,034

Bacteriophage endolysins and novel lipid-degrading proteins as a treatment for Rhodococcus equi infections in foals

2018 - 2019
Rhodococcus equi (Req) is responsible for severe respiratory disease of foals with a major economic impact on the equine industry, and can be endemic on stud farms. In foals under 6 months of age, thi...
Funder: Horserace Betting Levy Board | Value: £10,832

Direct and paracrine effects of Chlamydia infection on decidualisation of endometrial stromal cells

2018 - 2018
SRF summer studentship
Funder: Society for Reproduction and Fertility | Value: £2,750